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@article{Tanner:2021:10.1136/thoraxjnl-2020-216304,
author = {Tanner, N and Saglani, S and Li, AM and Bush, A and Fleming, L},
doi = {10.1136/thoraxjnl-2020-216304},
journal = {Thorax},
pages = {398--399},
title = {Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux},
url = {http://dx.doi.org/10.1136/thoraxjnl-2020-216304},
volume = {77},
year = {2021}
}

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TY  - JOUR
AB  - The relationship between childhood asthma and gastro-oesophageal reflux (GOR) is contentious. Recent studies in adult asthmatics suggest that GOR is associated with worse control and differences in sputum proteomics related to epithelial integrity, systemic inflammation and host defence. We assessed 127 children with severe asthma undergoing bronchoscopy and pH study. There were no differences in asthma control or measures of airway inflammation or remodelling when those with acid GOR were compared with those without. These results suggest that acid GOR is not an important comorbidity in paediatric severe asthma.
AU  - Tanner,N
AU  - Saglani,S
AU  - Li,AM
AU  - Bush,A
AU  - Fleming,L
DO  - 10.1136/thoraxjnl-2020-216304
EP  - 399
PY  - 2021///
SN  - 0040-6376
SP  - 398
TI  - Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thoraxjnl-2020-216304
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34497139
UR  - https://thorax.bmj.com/content/77/4/398
UR  - http://hdl.handle.net/10044/1/92108
VL  - 77
ER  -

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