Summary
Luke Howard is a Consultant Pulmonologist and Lead Clinician for the Pulmonary Hypertension Service, based at Hammersmith Hospital, Imperial College Healthcare NHS Trust. He is also Lead Clinician for Exercise Physiology services at Imperial College Healthcare. Areas of research interest include cardiopulmonary physiology, and early and late phase clinical trials, particularly in the field of Pulmonary Hypertension and Pulmonary Embolism. The Pulmonary Hypertension Service is one of the designated units in the National Pulmonary Hypertension Service which is a clinical and research network which aims to deliver excellent clinical outcomes and promote basic, translational and clinical research in the field of pulmonary vascular disease.
Selected Publications
Journal Articles
Su J, Manisty C, Parker KH, et al., 2017, Wave Intensity Analysis Provides Novel Insights Into Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension., Journal of the American Heart Association, Vol:6, ISSN:2047-9980
Michelakis ED, Gurtu V, Webster L, et al., 2017, Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients, Science Translational Medicine, Vol:9, ISSN:1946-6234, Pages:1-13
Ghofrani H-A, Simonneau G, D'Armini AM, et al., 2017, Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study, The Lancet Respiratory Medicine, Vol:5, ISSN:2213-2600, Pages:785-794
Dumitrescu D, Sitbon O, Weatherald J, et al., 2017, Exertional dyspnoea in pulmonary arterial hypertension., European Respiratory Review, Vol:26, ISSN:0905-9180
Su J, Manisty C, Simonsen U, et al., 2017, Pulmonary artery wave propagation and reservoir function in conscious man: impact of pulmonary vascular disease, respiration and dynamic stress tests, Journal of Physiology - London, Vol:595, ISSN:0022-3751, Pages:6463-6476
Rhodes CJ, Wharton J, Ghataorhe P, et al., 2017, Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study, Lancet Respiratory Medicine, Vol:5, ISSN:2213-2600, Pages:717-726
Dawes T, Simoes monteiro de marvao A, Shi W, et al., 2017, Machine learning of three-dimensional right ventricular motion enables outcome prediction in pulmonary hypertension: a cardiac MR imaging study, Radiology, Vol:283, ISSN:1527-1315, Pages:381-390
Rehman MB, Howard LS, Christiaens LP, et al., 2017, Resting right ventricular function is associated with exercise performance in PAH, but not in CTEPH., Eur Heart J Cardiovasc Imaging
Rhodes CJ, Ghataorhe P, Wharton J, et al., 2017, Plasma metabolomics implicate modified transfer RNAs and altered bioenergetics in the outcome of pulmonary arterial hypertension, Circulation, Vol:135, ISSN:0009-7322, Pages:460-475
Charalampopoulos A, Gibbs JS, Davies RJ, et al., 2016, Exercise physiological responses to drug treatments in chronic thromboembolic pulmonary hypertension, Journal of Applied Physiology, Vol:121, ISSN:8750-7587, Pages:623-628
Becattini C, Cohen AT, Agnelli G, et al., 2016, Risk stratification of patients with acute symptomatic pulmonary embolism based on presence or absence of lower extremity DVT systematic review and meta-analysis, Chest, Vol:149, ISSN:1931-3543, Pages:192-200
Thom HHZ, Capkun G, Cerulli A, et al., 2015, Network meta-analysis combining individual patient and aggregate data from a mixture of study designs with an application to pulmonary arterial hypertension, BMC Medical Research Methodology, Vol:15, ISSN:1471-2288
Charalampopoulos A, Howard LS, Tzoulaki I, et al., 2014, Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors, Pulmonary Circulation, Vol:4, ISSN:2045-8932, Pages:669-678
Howard LSGE, Santhirapala V, Murphy K, et al., 2014, Cardiopulmonary Exercise Testing Demonstrates Maintenance of Exercise Capacity in Patients With Hypoxemia and Pulmonary Arteriovenous Malformations, Chest, Vol:146, ISSN:0012-3692, Pages:709-718
Corte TJ, Keir GJ, Dimopoulos K, et al., 2014, Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia, American Journal of Respiratory and Critical Care Medicine, Vol:190, ISSN:1073-449X, Pages:208-217
Ruiter G, Lanser IJ, de Man FS, et al., 2014, Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension, Rheumatology, Vol:53, ISSN:1462-0324, Pages:285-292
McLaughlin VV, Gaine SP, Howard LS, et al., 2013, Treatment Goals of Pulmonary Hypertension, Journal of the American College of Cardiology, Vol:62, ISSN:0735-1097, Pages:D73-D81
Guillevin L, Armstrong I, Aldrighetti R, et al., 2013, Understanding the impact of pulmonary arterial hypertension on patients' and carers' lives., Eur Respir Rev, Vol:22, Pages:535-542
Howard LS, 2013, Last call for the flight simulation test?, European Respiratory Journal, Vol:42, ISSN:0903-1936, Pages:1175-1177
Cabrita IZ, Mohammed A, Layton M, et al., 2013, The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom, British Journal of Haematology, Vol:162, ISSN:0007-1048, Pages:400-408
Zhao L, Ashek A, Wang L, et al., 2013, Heterogeneity in lung 18FDG uptake in PAH: potential of dynamic 18FDG-PET with kinetic analysis as a bridging biomarker for pulmonary remodeling targeted treatments, Circulation
Howard LS, Hughes RJ, 2013, NICE guideline: management of venous thromboembolic diseases and role of thrombophilia testing, Thorax, Vol:68, ISSN:0040-6376, Pages:391-393
Rhodes CJ, Wharton J, Boon RA, et al., 2013, Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension., American Journal of Respiratory and Critical Care Medicine, Vol:187, Pages:294-302
Howard LSGE, Watson GMJ, Wharton J, et al., 2013, Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension, Pulmonary Circulation, Vol:3, ISSN:2045-8940, Pages:100-107
Ling Y, Johnson MK, Kiely DG, et al., 2012, Changing Demographics, Epidemiology, and Survival of Incident Pulmonary Arterial Hypertension Results from the Pulmonary Hypertension Registry of the United Kingdom and Ireland, American Journal of Respiratory and Critical Care Medicine, Vol:186, ISSN:1073-449X, Pages:790-796
Howard LS, Grapsa J, Dawson D, et al., 2012, Echocardiographic assessment of pulmonary hypertension: standard operating procedure., Eur Respir Rev, Vol:21, Pages:239-248
Grapsa J, Gibbs JSR, Cabrita IZ, et al., 2012, The association of clinical outcome with right atrial and ventricular remodelling in patients with pulmonary arterial hypertension: study with real-time three-dimensional echocardiography, European Heart Journal-cardiovascular Imaging, Vol:13, ISSN:2047-2404, Pages:666-672
Howard LS, Crosby A, Vaughan P, et al., 2012, Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema., Pulmonary Circulation, Vol:2, ISSN:2045-8940, Pages:241-249
Grapsa J, Gibbs JSR, Dawson D, et al., 2012, Morphologic and Functional Remodeling of the Right Ventricle in Pulmonary Hypertension by Real Time Three Dimensional Echocardiography, American Journal of Cardiology, Vol:109, ISSN:0002-9149, Pages:906-913
Zhai Z, Murphy K, Tighe H, et al., 2011, Differences in Ventilatory Inefficiency Between Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension, Chest, Vol:140, ISSN:0012-3692, Pages:1284-1291
Ahmedzai S, Balfour-Lynn IM, Bewick T, et al., 2011, Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations, Thorax, Vol:66, ISSN:0040-6376, Pages:1-30
Rhodes CJ, Howard LS, Busbridge M, et al., 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, Journal of the American College of Cardiology, Vol:58, ISSN:0735-1097, Pages:300-309
Howard L, Salooja N, 2011, Outpatient management of pulmonary embolism, The Lancet, Vol:378, ISSN:0140-6736, Pages:5-6
Rhodes CJ, Wharton J, Howard LS, et al., 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, Heart, Vol:97, ISSN:1355-6037, Pages:1054-1060
Cabrita IZ, Ruisanchez C, Dawson D, et al., 2010, Right ventricular function in patients with pulmonary hypertension; the value of myocardial performance index measured by tissue Doppler imaging, European Journal of Echocardiography, Vol:11, ISSN:1525-2167, Pages:719-724
Wilkins MR, Ali O, Bradlow W, et al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, American Journal of Respiratory and Critical Care Medicine, Vol:181, ISSN:1073-449X, Pages:1106-1113
Toshner M, Voswinckel R, Southwood M, et al., 2009, Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension, American Journal of Respiratory and Critical Care Medicine, Vol:180, ISSN:1073-449X, Pages:780-787
Diller G-P, Bedard E, Wort SJ, et al., 2009, Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension", Circulation, Vol:119, ISSN:0009-7322, Pages:E231-E231
Price LC, Montani D, Perros F, et al., 2009, Dexamethasone Reverses Vascular Remodelling in Monocrotaline Pulmonary Arterial Hypertension., American Journal of Respiratory and Critical Care Medicine, Vol:179, ISSN:1073-449X
Creagh-Brown BC, Nicholson AG, Showkathali R, et al., 2008, Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil, Thorax, Vol:63, ISSN:0040-6376, Pages:933-934
Diller G-P, van Eijl S, Okonko DO, et al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, Circulation, Vol:117, ISSN:0009-7322, Pages:3020-3030
Tansley JG, Fatemian M, Howard LSGE, et al., 1998, Changes in respiratory control during and after 48 h of isocapnic and poikilocapnic hypoxia in humans, Journal of Applied Physiology, Vol:85, ISSN:8750-7587, Pages:2125-2134
HOWARD L, ROBBINS PA, 1995, ALTERATIONS IN RESPIRATORY CONTROL DURING 8-H OF ISOCAPNIC AND POIKILOCAPNIC HYPOXIA IN HUMANS, Journal of Applied Physiology, Vol:78, ISSN:8750-7587, Pages:1098-1107
Howard LSGE, Robbins PA, 1995, A comparison between the effects of 8 hours of isocapnic hypoxia and 8 hours of poikilocapnic hypoxia on respiratory control in humans, Advances in Experimental Medicine and Biology, Vol:393, ISSN:0065-2598, Pages:277-281
HOWARD L, ROBBINS PA, 1994, PROBLEMS WITH DETERMINING THE HYPOXIC RESPONSE IN HUMANS USING STEPWISE CHANGES IN END-TIDAL P-O2, Respiration Physiology, Vol:98, ISSN:0034-5687, Pages:241-249
PATERSON DH, CLEMENT ID, HOWARD LS, et al., 1993, THE HUMAN VENTILATORY RESPONSE TO STEP CHANGES IN END-TIDAL PO2 OF DIFFERING AMPLITUDE, Respiration Physiology, Vol:94, ISSN:0034-5687, Pages:309-321
SPRINGALL DR, POLAK JM, HOWARD L, et al., 1990, PERSISTENCE OF INTRINSIC NEURONS AND POSSIBLE PHENOTYPIC CHANGES AFTER EXTRINSIC DENERVATION OF HUMAN RESPIRATORY-TRACT BY HEART-LUNG TRANSPLANTATION, The American Review of Respiratory Disease, Vol:141, ISSN:0003-0805, Pages:1538-1546