Publications
337 results found
Grapsa J, O'regan D, Durighel G, et al., 2010, Predicting clinical deterioration in pulmonary arterial hypertensive patients with the assessment of right ventricular volumes and mass using cardiac MRI, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 752-752, ISSN: 0195-668X
Grapsa J, Gibbs JSR, Athanasiou T, et al., 2010, Morphologic and functional remodeling of the right ventricle in pulmonary hypertension: the role of real time three dimensional echocardiography, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 751-752, ISSN: 0195-668X
Grapsa J, Dawson D, Bellamy MF, et al., 2010, Echocardiographic determinants of survival in pulmonary hypertension, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 753-753, ISSN: 0195-668X
O'Driscoll BR, Howard LS, Davison AG, 2010, <i>Oxygen in myocardial infarction</i> Maintain normoxaemia until more evidence is available, BMJ-BRITISH MEDICAL JOURNAL, Vol: 341, ISSN: 1756-1833
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- Citations: 5
Wilkins MR, Ali O, Bradlow W, et al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, Pages: 1106-1113, ISSN: 1073-449X
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- Citations: 99
Wilkins MR, Ali O, Bradlow W, et al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, American Journal of Respiratory and Critical Care Medicine, Vol: 181, Pages: 1106-1113, ISSN: 1073-449X
Quintana FJ, Iglesias AH, Farez MF, et al., 2010, Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish, PLOS ONE, Vol: 5, ISSN: 1932-6203
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- Citations: 64
Wilkins MR, Ali O, Bradlow W, et al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial (SiPHT)., Am J Respir Crit Care Med
RATIONALE: In animal models of pulmonary hypertension, simvastatin has been shown to reduce pulmonary artery pressure and induce regression of associated right ventricular (RV) hypertrophy. OBJECTIVES: To assess the therapeutic value of simvastatin in patients with pulmonary arterial hypertension (PAH). METHODS: Forty-two patients with PAH were randomised to receive either simvastatin (80mg/day) or placebo in addition to current care for 6 months, and thereafter offered open-label simvastatin. The primary outcome was change in RV mass, assessed by cardiac magnetic resonance (CMR). MEASUREMENTS AND MAIN RESULTS: At 6 months, RV mass decreased by 5.2 +/- 11 g in the statin group (p=0.045) and increased 3.9 +/- 14 g in the placebo group. The treatment effect was -9.1 g (p=0.028). NT-proBNP levels fell significantly in the statin group (-75 +/- 167 fmol.ml(-1), p=0.02) but not the placebo group (49 +/- 224 fmol.ml(-1), p=0.43, overall treatment effect -124 fmol.ml(-1), p=0.041). There were no significant changes in other outcome measures (including 6 minute walk test, cardiac output and circulating cytokines). From 6 to 12 months, both RV mass and NT-proBNP increased towards baseline values in 16 patients on active treatment who continued with simvastatin but remained stable in 18 patients who switched from placebo to simvastatin. Two patients required a reduction in dose but not cessation of simvastatin. CONCLUSION: Simvastatin added to conventional therapy produces a small and transient early reduction in RV mass and NT-proBNP levels in PAH patients but this is not sustained over 12 months. Clinical Trials Registration Information: URL: http://www.clinicaltrials.gov Unique identifier: NCT00180713.
Barron AJ, Medlow KI, Giannoni A, et al., 2010, Reduced confounding by impaired ventilatory function with oxygen uptake efficiency slope and VE/VCO2 slope rather than peak oxygen consumption to assess exercise physiology in suspected heart failure., Congest Heart Fail, Vol: 16, Pages: 259-264
Heart failure and ventilatory disease often coexist; both create abnormalities in cardiopulmonary exercise test measurements. The authors evaluated the relative dependency of a well-recognized index of heart failure, peak oxygen consumption (VO(2)), and 2 newer indices, the minute ventilation (VE)/carbon dioxide production (VCO(2)) slope and oxygen uptake efficiency slope (OUES), on standard markers of impaired cardiac and ventilatory function. One hundred twenty-four patients (median age, 65.8; range, 22.6-84.9), with functional limitation from clinical heart failure were exercised. Peak VO(2) was 17.14 ± 7.58 mL/kg/min, VE/VCO(2) slope 50.1 ± 20.1, OUES 1.46 ± 0.68 L/min, and forced expiratory volume in 1 second (FEV(1) ) 1.88 ± 0.75 L. Peak VO(2) is substantially more sensitive to FEV(1) than ejection fraction (4.0 mL/kg/min difference between above- and below-median FEV(1) and 1.5 mL/kg/min between above- and below-median ejection fraction). OUES does not share this peculiar excess sensitivity to FEV(1) (0.12 L/min difference between above- and below-median FEV(1) and 0.01 L/min between above- and below-median ejection fraction). VE/VCO(2) slope has a borderline effect by FEV(1) (7.07 difference between above- and below-median FEV(1) and 2.07 between above- and below-median ejection fraction). Although widely used as a marker of heart failure severity, peak VO(2) is very sensitive to spirometry status and is indeed more affected by FEV(1) than by ejection fraction. OUES in contrast does not show this preferential sensitivity to impaired FEV(1).
Howard LS, 2010, Pathophysiology of hypoxaemic respiratory failure, Non-invasive Ventilation and Weaning Principles and Practive, Editors: Elliot, Nava, Schonhofer, Publisher: Hodder Arnold, Pages: 239-244, ISBN: 9780340941522
Non-Invasive Ventilation and Weaning: Principles and Practice provides up-to-date,authoritative, and comprehensive information from a prestigious range of ...
Toshner M, Southwood M, Al-Lamki R, et al., 2009, ENDOTHELIAL PROGENITOR CELLS ARE DYSFUNCTIONAL IN PULMONARY HYPERTENSION, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A2-A2, ISSN: 0040-6376
Galie N, Hoeper MM, Humbert M, et al., 2009, Guidelines for the diagnosis and treatment of pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 1219-1263, ISSN: 0903-1936
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- Citations: 897
Grapsa J, Pavlopoulos H, Pandis D, et al., 2009, Right Ventricular Remodeling and the Tricuspid Apparatus in Different Types of Pulmonary Hypertension: A Study With Real Time 3D Echocardiography, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S309-S309, ISSN: 0009-7322
Rhodes CJ, Wharton J, Howard L, et al., 2009, Growth Differentiation Factor-15 as a Biomarker in Pulmonary Arterial Hypertension and Hypoxia-induced Pulmonary Hypertension, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S1135-S1135, ISSN: 0009-7322
Toshner M, Voswinckel R, Southwood M, et al., 2009, Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 180, Pages: 780-787, ISSN: 1073-449X
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- Citations: 174
Galie N, Hoeper MM, Humbert M, et al., 2009, Guidelines for the diagnosis and treatment of pulmonary hypertension, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 2493-2537, ISSN: 0195-668X
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- Citations: 2635
Zota V, Nemirovsky A, Baron R, et al., 2009, HLA-DR Alleles in Amyloid β-Peptide Autoimmunity: A Highly Immunogenic Role for the DRB1*1501 Allele, JOURNAL OF IMMUNOLOGY, Vol: 183, Pages: 3522-3530, ISSN: 0022-1767
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- Citations: 37
Grapsa J, Malcolme-Lawes L, Gin-Sing W, et al., 2009, Echocardiographic parameters which determine survival in pulmonary hypertension: retrospective study of 1186 patients, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 897-898, ISSN: 0195-668X
Grapsa J, Pandis D, Stefanou D, et al., 2009, A Novel 3D echocardiographic geometrical model of the tricuspid valve for the assessment of different modalities of right ventricular remodeling, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 114-114, ISSN: 0195-668X
Grapsa J, Dawson D, Sulemane S, et al., 2009, Right ventricular speckle tracking in right and left heart disease. Correlation with conventional two dimensional echocardiographic indices, EUROPEAN HEART JOURNAL, Vol: 30, Pages: 116-116, ISSN: 0195-668X
Howard LS, 2009, Oxygen therapy, CLINICAL MEDICINE, Vol: 9, Pages: 156-159, ISSN: 1470-2118
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- Citations: 5
De Jager PL, Baecher-Allan C, Maier LM, et al., 2009, The role of the <i>CD58</i> locus in multiple sclerosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 5264-5269, ISSN: 0027-8424
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- Citations: 141
Diller G-P, Bedard E, Wort SJ, et al., 2009, Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension", CIRCULATION, Vol: 119, Pages: E231-E231, ISSN: 0009-7322
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- Citations: 1
Galiè N, Hoeper MM, Humbert M, et al., 2009, Pulmoner hipertansiyon tani ve tedavi kilavuzu, Turk Kardiyoloji Dernegi Arsivi, Vol: 37, Pages: 1-46, ISSN: 1016-5169
Price LC, Montani D, Perros F, et al., 2009, Dexamethasone Reverses Vascular Remodelling in Monocrotaline Pulmonary Arterial Hypertension., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X
Creagh-Brown BC, Nicholson AG, Showkathali R, et al., 2008, Pulmonary veno-occlusive disease presenting with recurrent pulmonary oedema and the use of nitric oxide to predict response to sildenafil, THORAX, Vol: 63, Pages: 933-934, ISSN: 0040-6376
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- Citations: 27
O'Driscoll BR, Howard LS, Davison AG, 2008, BTS guideline for emergency oxygen use in adult patients, THORAX, Vol: 63, ISSN: 0040-6376
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- Citations: 555
Davison AG, O'Driscoll R, Howard LSGE, 2008, Oxygen therapy during exacerbations, Chronic obstructive pulmonary disease exacerbations, Editors: Wedzicha, Martinez, Publisher: Informa HealthCare, Pages: 293-302, ISBN: 9781420070866
Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD ...
Diller G-P, van Eijl S, Okonko DO, et al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 117, Pages: 3020-3030, ISSN: 0009-7322
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- Citations: 171
Gibbs JSR, 2008, Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland, HEART, Vol: 94, ISSN: 1355-6037
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- Citations: 7
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