Publications
337 results found
Ling Y, Johnson MK, Kiely D, et al., 2011, INFLUENCE OF AGE ON CLINICAL PHENOTYPES OF INCIDENT IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION. RESULTS FROM THE PULMONARY HYPERTENSION REGISTRY OF THE UK AND IRELAND, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A34-A35, ISSN: 0040-6376
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- Citations: 2
Fagerbrink S, Mukherjee B, Sirisena D, et al., 2011, INCIDENCE OF PERSISTENT PERFUSION DEFECTS FOLLOWING PULMONARY EMBOLISM: IMPACT ON PULMONARY ARTERY SYSTOLIC PRESSURE AT 6 MONTHS, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A14-A14, ISSN: 0040-6376
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- Citations: 1
Mukherjee B, Sirisena D, Murphy K, et al., 2011, CLINICAL AND ECONOMIC BENEFIT OF CARDIOPULMONARY EXERCISE TESTING (CPX) IN PULMONARY HYPERTENSION, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A67-A67, ISSN: 0040-6376
Grapsa J, Dawson D, Jakaj G, et al., 2011, Geometrical 3D Echocardiographic Reconstruction of the Different Right Ventricular Remodeling in Pulmonary Hypertensive Patients, CIRCULATION, Vol: 124, ISSN: 0009-7322
Zhai Z, Murphy K, Tighe H, et al., 2011, Differences in Ventilatory Inefficiency Between Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension, CHEST, Vol: 140, Pages: 1284-1291, ISSN: 0012-3692
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- Citations: 75
Ahmedzai S, Balfour-Lynn IM, Bewick T, et al., 2011, Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations, THORAX, Vol: 66, Pages: 1-30, ISSN: 0040-6376
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- Citations: 155
O'Driscoll BR, Howard LS, Bucknall C, et al., 2011, British Thoracic Society emergency oxygen audits, THORAX, Vol: 66, Pages: 734-735, ISSN: 0040-6376
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- Citations: 34
Grapsa J, Gibbs JSR, Dawson D, et al., 2011, Echocardiographic determinants of survival in pulmonary hypertension, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 436-437, ISSN: 0195-668X
Grapsa J, O'Reagan D, Cabrita IZ, et al., 2011, Learning curve of real time 3D echocardiography and cardiac magnetic resonance on right ventricular remodelling: be fast and accurate, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 1021-1021, ISSN: 0195-668X
Grapsa J, Gibbs JSR, Cabrita IZ, et al., 2011, Clinical outcome and right atrial remodeling in patients with pulmonary arterial hypertension: study with real time 3D Echocardiography, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 437-438, ISSN: 0195-668X
O'Driscoll BR, Howard LS, Davison AG, 2011, Emergency oxygen use in adult patients: concise guidance, CLINICAL MEDICINE, Vol: 11, Pages: 372-373, ISSN: 1470-2118
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- Citations: 23
Rhodes CJ, Howard LS, Busbridge M, et al., 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 58, Pages: 300-309, ISSN: 0735-1097
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- Citations: 181
Howard L, Salooja N, 2011, Outpatient management of pulmonary embolism, LANCET, Vol: 378, Pages: 5-6, ISSN: 0140-6736
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- Citations: 6
Rhodes CJ, Wharton J, Howard LS, et al., 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, HEART, Vol: 97, Pages: 1054-1060, ISSN: 1355-6037
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- Citations: 145
O'Driscoll BR, Howard LS, 2011, How to assess the dangers of hyperoxemia: methodological issues., Critical Care, Vol: 15, ISSN: 1364-8535
Showkathali R, Tayebjee MH, Grapsa J, et al., 2011, Right atrial flutter isthmus ablation is feasible and results in acute clinical improvement in patients with persistent atrial flutter and severe pulmonary arterial hypertension, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 149, Pages: 279-280, ISSN: 0167-5273
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- Citations: 29
Mukherjee B, Howard L, 2011, Combination therapy in pulmonary arterial hypertension: do we have the right strategy?, EXPERT REVIEW OF RESPIRATORY MEDICINE, Vol: 5, Pages: 191-205, ISSN: 1747-6348
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- Citations: 4
Kane B, Turkington PM, Howard LS, et al., 2011, LESSON OF THE WEEK Rebound hypoxaemia after administration of oxygen in an acute exacerbation of chronic obstructive pulmonary disease, BMJ-BRITISH MEDICAL JOURNAL, Vol: 342, ISSN: 1756-1833
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- Citations: 14
Robbins IM, Hemnes AR, Gibbs JS, et al., 2011, Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension, EXPERIMENTAL LUNG RESEARCH, Vol: 37, Pages: 26-34, ISSN: 0190-2148
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- Citations: 32
Price LC, Montani D, Tcherakian C, et al., 2011, Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats, Eur Respir J, Vol: 37, Pages: 813-822, ISSN: 1399-3003
Pulmonary arterial hypertension (PAH) is associated with dysregulated bone morphogenetic protein receptor (BMPR)-II signaling and pulmonary vascular inflammation. We evaluated the effects of dexamethasone on monocrotaline (MCT)-induced PAH in rats for potential reversal of PAH at late time-points. Saline-treated control, MCT-exposed, MCT-exposed and dexamethasone-treated rats (5 mg.kg(-)(1).day(-)(1), 1.25 mg.kg(-)(1) and 2.5 mg.kg(-)(1).48 h(-)(1)) were evaluated at day 28 and day 35 following MCT for haemodynamic parameters, right ventricular hypertrophy, morphometry, immunohistochemistry, and IL6 and BMPR2 expression. Dexamethasone improved haemodynamics and pulmonary vascular remodelling, preventing PAH development at early (day 1-14 and 1-28) and reversing PAH at late (day 14-28 and 21-35) time-points following MCT, as well as improving survival in MCT-exposed rats compared with controls. Both MCT-induced pulmonary IL6 overexpression and interleukin (IL)-6-expressing adventitial inflammatory cell infiltration were reduced with dexamethasone. This was associated with pulmonary BMPR2 downregulation following MCT, which was increased with dexamethasone, in whole lung and control pulmonary artery smooth muscle cells. Dexamethasone also reduced proliferation of rat pulmonary artery smooth muscle cells in vitro. Experimental PAH can be prevented and reversed by dexamethasone, and survival is improved. In this model, mechanisms may involve reduction of IL-6-expressing inflammatory cells, restoration of pulmonary BMPR2 expression and reduced proliferation of vascular smooth muscle cells.
Ling Y, Johnson M, Kiely DG, et al., 2011, Survival Of Incident Cases Of Idiopathic, Heritable And Anorexigen-Associated Pulmonary Arterial Hypertension. Results From Pulmonary Hypertension Registry Of The United Kingdom And Ireland (Proud Registry), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Bazin KA, Moosavi S, Murphy K, et al., 2010, CARBON DIOXIDE SENSITIVITY IN PATIENTS WITH HYPERVENTILATION SYNDROME, THORAX, Vol: 65, Pages: A134-A134, ISSN: 0040-6376
Rhodes CJ, Wharton J, Howard LS, et al., 2010, NOVEL BIOMARKERS IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A44-A44, ISSN: 0040-6376
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- Citations: 2
Zhai Z, Murphy K, Tighe H, et al., 2010, VENTILATORY EFFICIENCY IN PULMONARY ARTERIAL HYPERTENSION AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: PHYSIOLOGICAL DIFFERENCES AND IMPLICATIONS FOR DISEASE-SPECIFIC END-POINTS, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A45-A46, ISSN: 0040-6376
Rhodes CJ, Howard LS, Busbridge M, et al., 2010, IRON DEFICIENCY INDEPENDENTLY PREDICTS SURVIVAL IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A90-A91, ISSN: 0040-6376
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- Citations: 1
Price LC, Wort SJ, Montani D, et al., 2010, DEXAMETHASONE REVERSES ESTABLISHED MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RATS AND INCREASES PULMONARY BMPR2 EXPRESSION, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A68-A69, ISSN: 0040-6376
Grapsa J, O'Regan D, Dawson D, et al., 2010, Study of Rv Remodeling in Idiopathic Pulmonary Arterial Hypertension With 3D Echo and Cardiac MRI, CIRCULATION, Vol: 122, ISSN: 0009-7322
Henderson SR, Shah A, Banford KB, et al., 2010, Pig trotters lung - novel domestic transmission of <i>Pasteurella multocida</i>, CLINICAL MEDICINE, Vol: 10, Pages: 517-518, ISSN: 1470-2118
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- Citations: 8
Cabrita IZ, Ruisanchez C, Dawson D, et al., 2010, Right ventricular function in patients with pulmonary hypertension; the value of myocardial performance index measured by tissue Doppler imaging, EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, Vol: 11, Pages: 719-724, ISSN: 1525-2167
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- Citations: 25
Bradlow WM, Assomull RG, Williams F, et al., 2010, Cardiovascular magnetic resonance measured right ventricular mass influences prognosis in pulmonary arterial hypertension, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 8-8, ISSN: 0195-668X
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- Citations: 2
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