Publications

BibTex format

@article{Kariotis:2021:10.1038/s41467-021-27326-0,
author = {Kariotis, S and Jammeh, E and Swietlik, EM and Pickworth, JA and Rhodes, CJ and Otero, P and Wharton, J and Iremonger, J and Dunning, MJ and Pandya, D and Mascarenhas, TS and Errington, N and Thompson, AAR and Romanoski, CE and Rischard, F and Garcia, JGN and Yuan, JX-J and An, T-HS and Desai, AA and Coghlan, G and Lordan, J and Corris, PA and Howard, LS and Condliffe, R and Kiely, DG and Church, C and Pepke-Zaba, J and Toshner, M and Wort, S and Graf, S and Morrell, NW and Wilkins, MR and Lawrie, A and Wang, D and Bleda, M and Bleda, M and Hadinnapola, C and Haimel, M and Auckland, K and Tilly, T and Martin, JM and Yates, K and Treacy, CM and Day, M and Greenhalgh, A and Shipley, D and Peacock, AJ and Irvine, V and Kennedy, F and Moledina, S and MacDonald, L and Tamvaki, E and Barnes, A and Cookson, V and Chentouf, L and Ali, S and Othman, S and Ranganathan, L and Gibbs, JSR and DaCosta, R and Pinguel, J and Dormand, N and Parker, A and Stokes, D and Ghedia, D and Tan, Y and Ngcozana,},
doi = {10.1038/s41467-021-27326-0},
journal = {Nature Communications},
pages = {1--14},
title = {Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood},
url = {http://dx.doi.org/10.1038/s41467-021-27326-0},
volume = {12},
year = {2021}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms of pulmonary arterial hypertension, producing a heterogeneous population with varied treatment response. Here we show unsupervised machine learning identification of three major patient subgroups that account for 92% of the cohort, each with unique whole blood transcriptomic and clinical feature signatures. These subgroups are associated with poor, moderate, and good prognosis. The poor prognosis subgroup is associated with upregulation of the ALAS2 and downregulation of several immunoglobulin genes, while the good prognosis subgroup is defined by upregulation of the bone morphogenetic protein signalling regulator NOG, and the C/C variant of HLA-DPA1/DPB1 (independently associated with survival). These findings independently validated provide evidence for the existence of 3 major subgroups (endophenotypes) within the IPAH classification, could improve risk stratification and provide molecular insights into the pathogenesis of IPAH.
AU  - Kariotis,S
AU  - Jammeh,E
AU  - Swietlik,EM
AU  - Pickworth,JA
AU  - Rhodes,CJ
AU  - Otero,P
AU  - Wharton,J
AU  - Iremonger,J
AU  - Dunning,MJ
AU  - Pandya,D
AU  - Mascarenhas,TS
AU  - Errington,N
AU  - Thompson,AAR
AU  - Romanoski,CE
AU  - Rischard,F
AU  - Garcia,JGN
AU  - Yuan,JX-J
AU  - An,T-HS
AU  - Desai,AA
AU  - Coghlan,G
AU  - Lordan,J
AU  - Corris,PA
AU  - Howard,LS
AU  - Condliffe,R
AU  - Kiely,DG
AU  - Church,C
AU  - Pepke-Zaba,J
AU  - Toshner,M
AU  - Wort,S
AU  - Graf,S
AU  - Morrell,NW
AU  - Wilkins,MR
AU  - Lawrie,A
AU  - Wang,D
AU  - Bleda,M
AU  - Bleda,M
AU  - Hadinnapola,C
AU  - Haimel,M
AU  - Auckland,K
AU  - Tilly,T
AU  - Martin,JM
AU  - Yates,K
AU  - Treacy,CM
AU  - Day,M
AU  - Greenhalgh,A
AU  - Shipley,D
AU  - Peacock,AJ
AU  - Irvine,V
AU  - Kennedy,F
AU  - Moledina,S
AU  - MacDonald,L
AU  - Tamvaki,E
AU  - Barnes,A
AU  - Cookson,V
AU  - Chentouf,L
AU  - Ali,S
AU  - Othman,S
AU  - Ranganathan,L
AU  - Gibbs,JSR
AU  - DaCosta,R
AU  - Pinguel,J
AU  - Dormand,N
AU  - Parker,A
AU  - Stokes,D
AU  - Ghedia,D
AU  - Tan,Y
AU  - Ngcozana,T
AU  - Wanjiku,I
AU  - Polwarth,G
AU  - Mackenzie,Ross RV
AU  - Suntharalingam,J
AU  - Grover,M
AU  - Kirby,A
AU  - Grove,A
AU  - White,K
AU  - Seatter,A
AU  - Creaser-Myers,A
AU  - Walker,S
AU  - Roney,S
AU  - Elliot,CA
AU  - Charalampopoulos,A
AU  - Sabroe,I
AU  - Hameed,A
AU  - Armstrong,I
AU  - Hamilton,N
AU  - Rothman,AMK
AU  - Swift,AJ
AU  - Wild,JM
AU  - Soubrier,F
AU  - Eyries,M
AU  - Humbert,M
AU  - Montani,D
AU  - Girerd,B
AU  - Scelsi,L
AU  - Ghio,S
AU  - Gall,H
AU  - Ghofrani,A
AU  - Bogaard,HJ
AU  - Noordegraaf,AV
AU  - Houweling,AC
AU  - Veld,AHI
AU  - Schotte,G
DO  - 10.1038/s41467-021-27326-0
EP  - 14
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-27326-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000728559600008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-021-27326-0
UR  - http://hdl.handle.net/10044/1/93645
VL  - 12
ER  -

Download

DrLukeHoward

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)