Imperial College London
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DrLukeHoward

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Cardiopulmonary Medicine)
 
 
 
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Contact

 

+44 (0)20 3313 3171l.howard Website

 
 
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Location

 

B3113Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liew:2023:10.1016/j.ebiom.2022.104402,
author = {Liew, F and Talwar, S and Cross, A and Willett, B and Scott, S and Logan, N and Siggins, M and Swieboda, D and Sidhu, J and Efstathiou, C and Moore, S and Davis, C and Mohamed, N and Nunag, J and King, C and Thompson, AAR and Rowland-Jones, S and Docherty, A and Chalmers, J and Ho, L-P and Horsley, A and Raman, B and Poinasamy, K and Marks, M and Kon, OM and Howard, L and Wootton, D and Dunachie, S and Quint, J and Evans, R and Wain, L and Fontanella, S and de, Silva T and Ho, A and Harrison, E and Baillie, JK and Semple, MG and Brightling, C and Thwaites, R and Turtle, L and Openshaw, P},
doi = {10.1016/j.ebiom.2022.104402},
journal = {EBioMedicine},
pages = {1--14},
title = {SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination},
url = {http://dx.doi.org/10.1016/j.ebiom.2022.104402},
volume = {87},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced.Methods:In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data.Findings:Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination.Interpretation:The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity.Funding:This
AU  - Liew,F
AU  - Talwar,S
AU  - Cross,A
AU  - Willett,B
AU  - Scott,S
AU  - Logan,N
AU  - Siggins,M
AU  - Swieboda,D
AU  - Sidhu,J
AU  - Efstathiou,C
AU  - Moore,S
AU  - Davis,C
AU  - Mohamed,N
AU  - Nunag,J
AU  - King,C
AU  - Thompson,AAR
AU  - Rowland-Jones,S
AU  - Docherty,A
AU  - Chalmers,J
AU  - Ho,L-P
AU  - Horsley,A
AU  - Raman,B
AU  - Poinasamy,K
AU  - Marks,M
AU  - Kon,OM
AU  - Howard,L
AU  - Wootton,D
AU  - Dunachie,S
AU  - Quint,J
AU  - Evans,R
AU  - Wain,L
AU  - Fontanella,S
AU  - de,Silva T
AU  - Ho,A
AU  - Harrison,E
AU  - Baillie,JK
AU  - Semple,MG
AU  - Brightling,C
AU  - Thwaites,R
AU  - Turtle,L
AU  - Openshaw,P
DO  - 10.1016/j.ebiom.2022.104402
EP  - 14
PY  - 2023///
SN  - 2352-3964
SP  - 1
TI  - SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2022.104402
UR  - https://www.sciencedirect.com/science/article/pii/S2352396422005849?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101074
VL  - 87
ER  -
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