Summary
Professor Long R Jiao is a professor of surgery at Imperial College and consultant surgeon in hepatobiliary and pancreatic surgery at Royal Marsden Hospital, having studied in medicine at the Royal London Hospital Medical College and trained at the former Royal Postograduate Medical School, Guy's and St Thomas' and South East Hospitals. He was the chair of pancreatic and hepatobiliary surgery at Hammersmith Hospital before he moved to Royal Marsden Hospital to set up the 1st Robotic Hepatobiliary and Pancreatic surgery unit in the UK. He is one of the regional programme directors for surgical training and the court of examiners for both MRCS and FRCS for the Royal Colleges of Surgeons of England, Ireland, Edinburgh and Glasgow.
He has published over 200 peer-reviewed papers in journals such as Annals of Surgery, Journal of Clinical Oncology, Hepatology and Lancet. He published the 1st article on radiofrequency in liver cancer in the world which has been cited extensively worldwide. His main research interests include surgical technology and cancer biology, and early detection for pancreatic cancer. He has set up a minimum invasive unit at Hammersmith Hospital for hepatopancreaticobiliary (HPB) diseases, performing Whipple's operation and major liver resection laparoscopically as routine. Over the last 4 years, he has developed robotic HPB surgery in the UK, having performed and published the 1st Robotic Whipple's operation for pancreatic cancer and the 1st major liver and synchronous liver resection for liver and biliary cancer in the UK. He has developed a broad clinical and laboratory programme encompassing gold standards in operative procedure as well as genomic and proteomics research. He has invented a few innovative surgical procedures such as RALPPS to induce liver regeneration prior to major liver resection and non touch and new anastomotic techniques for pancreatic operation to improved the outcomes of surgery for pancreatic cancer. His current research focus is on new biomarkers for early detection of pancreatic cancer and recurrent disease after curative pancreatic resection for cancer. His ambition is to improve the survival of pancreatic cancer.
He is in charge of clinical and educational supervision of surgical trainees at the Northwest Thames which has been featured on the TV programme of "School of Surgery' and is the local chair for postgraduate study. He is invovled in undergradute teaching for medical students and medical schoool interviews for students. He is supervising a number of PhD and MD students. He is the course lead for two surgical MSc courses.
He is a Fellow of the Royal College of Surgeons of England, International Hepatopancreaticobiliary Association, and the American Association of Clinical Oncology, and sits on the advisory Boards of a few pharmaceutical committes. He is on the editorial board of a number of world leading hepatopancreaticobiliary journals.
Selected Publications
Journal Articles
Ghaneh P, Palmer D, Cicconi S, et al., 2023, Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial., Lancet Gastroenterol Hepatol, Vol:8, Pages:157-168
Xu L, Ramadan S, Rosa BG, et al., 2022, On-chip integrated graphene aptasensor with portable readout for fast and label-free COVID-19 detection in virus transport medium., Sens Diagn, Vol:1, Pages:719-730
Gall TMH, Alrawashdeh W, Soomro N, et al., 2020, Shortening surgical training through robotics: randomized clinical trial of laparoscopic versus robotic surgical learning curves., Bjs Open, Vol:4, Pages:1100-1108
Gall TMH, Pencavel TD, Cunningham D, et al., 2020, Transition from open and laparoscopic to robotic pancreaticoduodenectomy in a UK tertiary referral hepatobiliary and pancreatic centre - Early experience of robotic pancreaticoduodenectomy, HPB, Vol:22, ISSN:1365-182X, Pages:1637-1644
Fang C, An J, Bruno A, et al., 2020, Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseases, Hepatology International, Vol:14, ISSN:1936-0533, Pages:437-453
Ghaneh P, Palmer DH, Cicconi S, et al., 2020, ESPAC-5F: Four-arm, prospective, multicenter, international randomized phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer., Journal of Clinical Oncology, Vol:38, ISSN:0732-183X, Pages:4505-4505
Ottaviani S, Stebbing J, Frampton AE, et al., 2019, Author Correction: TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression, Nature Communications, Vol:10, ISSN:2041-1723
Liu DSK, Prado MM, Giovannetti E, et al., 2019, Can circulating tumor and exosomal nucleic acids act as biomarkers for pancreatic ductal adenocarcinoma?, Expert Review of Molecular Diagnostics, Vol:19, ISSN:1473-7159, Pages:553-558
Jiao LR, Fajardo Puerta AB, Gall TMH, et al., 2019, Rapid induction of liver regeneration for major hepatectomy (REBIRTH): A randomized controlled trial of portal vein embolisation versus ALPPS assisted with radiofrequency., Cancers, Vol:11, ISSN:2072-6694
Gall TMH, Gerrard G, Frampton AE, et al., 2019, Can we predict long-term survival in resectable pancreatic ductal adenocarcinoma?, Oncotarget, Vol:10, ISSN:1949-2553, Pages:696-706
Gall TM, Belete S, Khanderia E, et al., 2019, Circulating tumour cells and cell-free DNA in pancreatic ductal adenocarcinoma, American Journal of Pathology, Vol:189, ISSN:0002-9440, Pages:71-81
Ottaviani S, Stebbing J, Frampton AE, et al., 2018, TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression, Nature Communications, Vol:9, ISSN:2041-1723
Frampton AE, Mato Prado M, Lopez Jimenez ME, et al., 2018, Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden, Oncotarget, Vol:9, ISSN:1949-2553, Pages:19006-19013
Jawad ZAR, Theodorou I, Jiao LR, et al., 2017, Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9, Scientific Reports, Vol:7, ISSN:2045-2322
Erridge S, Pucher PH, Markar SR, et al., 2017, Meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma, British Journal of Surgery, Vol:104, ISSN:1365-2168, Pages:1433-1442
Erridge S, Sodergren MH, Jiao LR, 2016, Re: Gavriilidis et al., 'Survival following redo hepatectomy vs radiofrequency ablation for recurrent hepatocellular carcinoma: a systematic review and meta-analysis', HPB, Vol:19, ISSN:1365-182X, Pages:378-378
Jiao LR, Hakim DN, Gall TMH, et al., 2016, A totally laparoscopic associating liver partition and portal vein ligation for staged hepatectomy assisted with radiofrequency (radiofrequency assisted liver partition with portal vein ligation) for staged liver resection, Hepatobiliary Surgery and Nutrition, Vol:5, ISSN:2304-3881, Pages:382-387
Jiao LR, 2016, Percutaneous Microwave Ablation Liver Partition and Portal Vein Embolization for Rapid Liver Regeneration: A Minimally Invasive First Step of ALPPS for Hepatocellular Carcinoma, Annals of Surgery, Vol:264, ISSN:1528-1140, Pages:E3-E3
Jiao LR, Gall TM, Sodergren MH, et al., 2016, Laparoscopic long sleeve pancreaticogastrostomy (LPG): a novel pancreatic anastomosis following central pancreatectomy, Hepatobiliary Surgery and Nutrition, Vol:5, ISSN:2304-389X, Pages:245-248
Giglio MC, Giakoustidis A, Draz A, et al., 2016, Oncological outcomes of major liver resection following portal vein embolization: a systematic review and a meta-analysis, Annals of Surgical Oncology, Vol:23, ISSN:1534-4681, Pages:3709-3717
Jiao LR, Fajardo A, Frampton A, 2016, Gene of the month: HGF, Journal of Clinical Pathology, Vol:69, ISSN:0021-9746, Pages:575-579
Frampton AE, Krell J, Mato Prado M, et al., 2016, Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies, Oncotarget, Vol:7, ISSN:1949-2553
Jawad ZAR, Tsim N, Pai M, et al., 2016, Short and long-term post-operative outcomes of duodenum preserving pancreatic head resection for chronic pancreatitis affecting the head of pancreas: a systematic review and meta-analysis, HPB, Vol:18, ISSN:1365-182X, Pages:121-128
Edmondson MJ, Sodergren MH, Pucher PH, et al., 2015, Variations and adaptations of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS): Many routes to the summit, Surgery, Vol:159, ISSN:1532-7361, Pages:1058-1072
Jawad Z, Xie F, Jiao LR, 2015, Applications of Nanotechnology in the Management of Cancer Miniature Technology, Great Potential, Jama Surgery, Vol:150, ISSN:2168-6254, Pages:1184-1185
Gall TMH, Tsakok M, Wasan H, et al., 2015, Pancreatic cancer: current management and treatment strategies, Postgraduate Medical Journal, Vol:91, ISSN:0032-5473, Pages:601-607
Gall TMH, Wasan H, Jiao LR, 2015, Pancreatic cancer: current understanding of molecular and genetic aetiologies, Postgraduate Medical Journal, Vol:91, ISSN:0032-5473, Pages:594-600
Frampton AE, Krell J, Gall TMH, et al., 2015, miR-15b and miR-17 Are Tumor-derived Plasma MicroRNAs Dysregulated in Colorectal Neoplasia, Annals of Surgery, Vol:262, ISSN:0003-4932, Pages:e61-e61
Frampton AE, Krell J, Jamieson NB, et al., 2015, microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis, European Journal of Cancer, Vol:51, ISSN:1879-0852, Pages:1389-1404
Frampton AE, Stebbing J, Gall TMH, et al., 2015, Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas, Expert Review of Molecular Diagnostics, Vol:15, ISSN:1473-7159, Pages:325-328
Frampton AE, Castellano L, Colombo T, et al., 2015, Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression, The Lancet, Vol:385, ISSN:0140-6736, Pages:37-37
Gall TMH, Sodergren MH, Frampton AE, et al., 2015, Radio-frequency-assisted Liver Partition With Portal Vein Ligation (RALPP) for Liver Regeneration, Annals of Surgery, Vol:261, ISSN:0003-4932, Pages:E45-E46
Gall TMH, Basyouny M, Frampton AE, et al., 2014, Neoadjuvant chemotherapy and primary-first approach for rectal cancer with synchronous liver metastases, Colorectal Disease, Vol:16, ISSN:1462-8910, Pages:O197-O205
Gall TMH, Jacob J, Frampton AE, et al., 2014, Reduced dissemination of circulating tumor cells with no-touch isolation surgical technique in patients with pancreatic cancer, Jama Surgery, Vol:149, ISSN:2168-6254, Pages:482-485
Frampton AE, Castellano L, Colombo T, et al., 2014, MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression, Gastroenterology, Vol:146, ISSN:0016-5085, Pages:268-+
Gall TMH, Frampton AE, Krell J, et al., 2013, Cell-free DNA for the detection of pancreatic, liver and upper gastrointestinal cancers: has progress been made?, Future Oncology, Vol:9, ISSN:1479-6694, Pages:1861-1869
Gall TMH, Frampton AE, Krell J, et al., 2013, Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?, Expert Review of Molecular Diagnostics, Vol:13, ISSN:1473-7159, Pages:793-796
Huang J, Zhang Y, Peng Z, et al., 2013, A modified TNM-7 staging system to better predict the survival in patients with hepatocellular carcinoma after hepatectomy, Journal of Cancer Research and Clinical Oncology, Vol:139, ISSN:0171-5216, Pages:1709-1719
Gall TMH, Frampton AE, Krell J, et al., 2013, Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer, Expert Review of Molecular Diagnostics, Vol:13, ISSN:1473-7159, Pages:141-145
Caponi S, Funel N, Frampton AE, et al., 2013, The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms, Annals of Oncology, Vol:24, ISSN:0923-7534, Pages:734-741
Gall TMH, Frampton AE, Krell J, et al., 2013, Circulating molecular markers in pancreatic cancer: ready for clinical use?, Future Oncology, Vol:9, ISSN:1479-6694, Pages:141-144
Walker NF, Warren OJ, Gawn L, et al., 2013, The role of genetic testing in management of hereditary chronic pancreatitis, Jrsm Open, Vol:4, ISSN:2054-2704, Pages:1-3
Frampton AE, Krell J, Zhang Y, et al., 2012, The role of miR-10b in metastatic pancreatic ductal adenocarcinoma, Surgery, Vol:152, ISSN:0039-6060, Pages:936-938
Zhang Y, Frampton AE, Martin JL, et al., 2012, 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors, Nuclear Medicine and Biology, Vol:39, ISSN:0969-8051, Pages:982-985
Zhang Y, Frampton AE, Cohen P, et al., 2012, Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma, Journal of Gastrointestinal Surgery, Vol:16, ISSN:1091-255X, Pages:1875-1882
Kyriakides C, Panagiotopoulos N, Jiao LR, 2012, Isolated Laparoscopic Caudate Lobe Resection, Surgical Laparoscopy Endoscopy & Percutaneous Techniques, Vol:22, ISSN:1530-4515, Pages:E209-E209
Zhang Y, Frampton AE, Kyriakides C, et al., 2012, Loco-recurrence after resection for ductal adenocarcinoma of the pancreas: predictors and implications for adjuvant chemoradiotherapy, Journal of Cancer Research and Clinical Oncology, Vol:138, ISSN:0171-5216, Pages:1063-1071
Jiao LR, Frampton AE, Jacob J, et al., 2012, MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors, PLOS One, Vol:7, ISSN:1932-6203
Tsim N, Healey AJ, Frampton AE, et al., 2011, Two-Stage Resection for Bilobar Colorectal Liver Metastases: R0 Resection Is the Key, Annals of Surgical Oncology, Vol:18, ISSN:1068-9265, Pages:1939-1946
Bitsakou G, Frampton AE, Pai M, et al., 2011, An Alternative Pancreatic Anastomosis Following Pancreaticoduodenectomy, Archives of Surgery, Vol:146, ISSN:0004-0010, Pages:752-754
Williamson JML, Thairu N, Katsoulas N, et al., 2010, Impact of portal vein embolization on expression of cancer stem cell markers in regenerated liver and colorectal liver metastases, Scandinavian Journal of Gastroenterology, Vol:45, ISSN:0036-5521, Pages:1472-1479
Frampton AE, Bong JJ, Kyriakides C, et al., 2010, En bloc resection of the pancreatic head and second part of duodenum for a duodenal gastrointestinal stromal tumor: a multi-media report., Jop, Vol:11, Pages:396-400
Jiao LR, Szydlo R, Habib NA, et al., 2010, Circulating Tumor Cells and Sample Size: The More, the Better Reply, Journal of Clinical Oncology, Vol:28, ISSN:0732-183X, Pages:E290-E290
Wickenden C, Castellano L, Jacob J, et al., 2010, No evidence for a viral association or aetiology in pancreatic cancer, Molecular Immunology, Vol:47, ISSN:0161-5890, Pages:639-639
Jiao LR, Apostolopoulos C, Jacob J, et al., 2009, Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases, Journal of Clinical Oncology, Vol:27, ISSN:0732-183X, Pages:6160-6165
Sommerville CAM, Limongelli P, Pai M, et al., 2009, Survival Analysis After Pancreatic Resection for Ampullary and Pancreatic Head Carcinoma: An Analysis of Clinicopathological Factors, Journal of Surgical Oncology, Vol:100, ISSN:0022-4790, Pages:651-656
Stebbing J, Jiao LR, 2009, Circulating tumour cells as more than prognostic markers, Lancet Oncology, Vol:10, ISSN:1470-2045, Pages:1138-1139
Jiao L, Apostolopoulos C, Jacob J, et al., 2009, The anatomic localization of circulating tumor cells and the immediate impact of surgery and radiofrequency ablation., J Clin Oncol, Vol:27
P Limongelli, SE Khorsandi, M Pai, et al., 2008, Management of delayed postoperative haemorrhage after pancreaticoduodenectomy: A meta-analysis, Arch Surg
Damrah OM, Bansi D, Tait P, et al., 2008, Repeat trans-arterial chemoembolisation for unresectable hepatocellular carcinoma: efficacy and long-term survival, Journal of Gastroenterology and Hepatology, Vol:23, ISSN:0815-9319, Pages:A43-A44
Abulkhir A, Limongelli P, Healey J, et al., 2008, Preoperative portal vein embolization for major liver reseaction. A meta-analysis, Annals of Surgery, Vol:247(1), Pages:49-57
Limongelli P, Pai M, Bansi D, et al., 2007, Correlation between preoperative biliary drainage, bile duct contamination and postoperative outcomes for pancreatic surgery, Surgery
Jiao LR, Tierris I, Ayav A, et al., 2006, A new technique for spleen preservation with radiofrequency, Surgery, Vol:140, ISSN:0039-6060, Pages:464-466
Gordon MY, Levicar N, Pai M, et al., 2006, Characterization and clinical application of human CD34(+) stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor, Stem Cells, Vol:24, ISSN:1066-5099, Pages:1822-1830
Ayav A, Habib N, Jiao LR, 2005, Portal hypertension secondary to (90)Yttrium microspheres: An unknown complication, Journal of Clinical Oncology, Vol:23, ISSN:0732-183X, Pages:8275-8276
Jiao LR, El-Desoky AA, Seifalian AM, et al., 2000, Effect of liver blood flow and function on hepatic indocyanine green clearance measured directly in a cirrhotic animal model, British Journal of Surgery, Vol:87, ISSN:0007-1323, Pages:568-574
Jiao LR, 1999, Percutaneous radiofrequency thermal ablation for liver tumours, Lancet
Jiao LR, Seifalian AM, Habib N, et al., 1999, The effect of mechanically enhancing portal venous inflow on hepatic oxygenation, microcirculation, and function in a rabbit model with extensive hepatic fibrosis, Hepatology, Vol:30, ISSN:0270-9139, Pages:46-52
Jiao LR, Hansen PD, Havlik R, et al., 1999, Clinical short term results of radiofrequency ablation in primary and secondary liver tumors, American Journal of Surgery, Vol:177, ISSN:0002-9610, Pages:303-306
Chapters
Jiao, LR, Williamson, et al., 2007, Small Bowel, General Surgery Operation, Editor(s): Kirk, Churchill Lingstone, Pages:209-227
L R Jiao, RCN Williamson, 2007, Small Bowel & Open Biliary Surgery, Essential General Surgical Operations, Editor(s): Kirk, Winslet, London, Churchhill Livingstone
Jiao LR, Habib NA, Zacharoulis D, 2007, The Use of SIRTEX in Inoperable Liver Tumours: A Surgeon's View, Liver and Biliary Track Surgery, Editor(s): Karaliotas, Broelsch, Habib, SpringeWien NY, Pages:419-420
Conference
Pugh S, Bridgewater J, Finch-Jones M, et al., 2017, Surgical quality and the impact of liver resection on outcome in the new EPOC study, 42nd European-Society-for-Medical-Oncology Congress (ESMO), OXFORD UNIV PRESS, ISSN:0923-7534
Kent L, Aydin A, Ahmed K, et al., 2017, A systematic review and meta-analysis of robotic versus laparoscopic partial liver resection, International Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Wiley, Pages:186-186, ISSN:1365-2168
Mallappa S, Poo S, Pencavel T, et al., 2017, Pancreatic incidentalomas on CT colonography: ignore, follow up or investigate?, International Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, WILEY, Pages:54-54, ISSN:0007-1323