Publications
293 results found
Chidambaram S, Kawka M, Gall TMH, et al., 2022, Can we predict the progression of premalignant pancreatic cystic tumors to ductal adenocarcinoma?, FUTURE ONCOLOGY, Vol: 18, Pages: 2605-2612, ISSN: 1479-6694
Mallappa S, Pencavel T, Poo S, et al., 2022, Pancreatic Incidentalomas on CT Colonography: Ignore, Follow up or Investigate?, CHIRURGIA, Vol: 117, Pages: 278-285, ISSN: 1221-9118
Gall TMH, Malhotra G, Elliott JA, et al., 2022, The Atlantic divide: contrasting surgical robotics training in the USA, UK and Ireland, JOURNAL OF ROBOTIC SURGERY, ISSN: 1863-2483
Kilic Y, Graham A, Tait NP, et al., 2022, Percutaneous biliary stone clearance: is there still a need? A 10-year single-centre experience, CLINICAL RADIOLOGY, Vol: 77, Pages: 130-135, ISSN: 0009-9260
Carbone F, Chee Y, Rasheed S, et al., 2022, Which surgical strategy for colorectal cancer with synchronous hepatic metastases provides the best outcome? A comparison between primary first, liver first and simultaneous approach, UPDATES IN SURGERY, Vol: 74, Pages: 451-465, ISSN: 2038-131X
Tabiri S, Kamarajah SK, Nepogodiev D, et al., 2022, Impact of Bacillus Calmette-Guerin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection, BJS Open, Vol: 5, ISSN: 2474-9842
Ahmed WUR, Bhatia S, McLean KA, et al., 2022, Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery, BJS OPEN, Vol: 6, ISSN: 2474-9842
Jiao L, Gall TMH, 2021, Author response to: Shortening surgical training through robotics: randomized clinical trial of laparoscopic versus robotic surgical learning curves., BJS Open, Vol: 5
Gupta S, Khan S, Kawka M, et al., 2021, Clinical utility of clonal origin determination in managing recurrent hepatocellular carcinoma, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 15, Pages: 1159-1167, ISSN: 1747-4124
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- Citations: 1
COVIDSurg Collaborative Co-authors, 2021, Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score, British Journal of Surgery, Vol: 108, Pages: 1274-1292, ISSN: 0007-1323
Since the beginning of the COVID-19 pandemic tens of millions of operations have been cancelled1 as a result of excessive postoperative pulmonary complications (51.2 per cent) and mortality rates (23.8 per cent) in patients with perioperative SARS-CoV-2 infection2. There is an urgent need to restart surgery safely in order to minimize the impact of untreated non-communicable disease.As rates of SARS-CoV-2 infection in elective surgery patients range from 1–9 per cent3–8, vaccination is expected to take years to implement globally9 and preoperative screening is likely to lead to increasing numbers of SARS-CoV-2-positive patients, perioperative SARS-CoV-2 infection will remain a challenge for the foreseeable future.To inform consent and shared decision-making, a robust, globally applicable score is needed to predict individualized mortality risk for patients with perioperative SARS-CoV-2 infection. The authors aimed to develop and validate a machine learning-based risk score to predict postoperative mortality risk in patients with perioperative SARS-CoV-2 infection.
Ahmed A, Morales-Conde S, Legrand M, et al., 2021, Clinical outcomes of pre-attached reinforced stapler reloads in bariatric surgery: A prospective case series, INTERNATIONAL JOURNAL OF SURGERY OPEN, Vol: 32, ISSN: 2405-8572
Glasbey JC, Omar O, Nepogodiev D, et al., 2021, Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic, BRITISH JOURNAL OF SURGERY, Vol: 108, Pages: 88-96, ISSN: 0007-1323
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- Citations: 33
Kawka M, Mak S, Qiu S, et al., 2021, Hepatic epithelioid hemangioendothelioma (HEHE)-rare vascular malignancy mimicking cholangiocarcinoma: a case report, TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
Gall TMH, Pencavel TD, Cunningham D, et al., 2020, Transition from open and laparoscopic to robotic pancreaticoduodenectomy in a UK tertiary referral hepatobiliary and pancreatic centre - Early experience of robotic pancreaticoduodenectomy, HPB, Vol: 22, Pages: 1637-1644, ISSN: 1365-182X
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- Citations: 4
Bhogal RH, Patel PH, Doran SLF, et al., 2020, Approach to upper GastroIntestinal cancer surgery during the COVID-19 pandemic - Experience from a UK cancer centre, EJSO, Vol: 46, Pages: 2156-2157, ISSN: 0748-7983
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- Citations: 3
Gall TMH, Alrawashdeh W, Soomro N, et al., 2020, Shortening surgical training through robotics: randomized clinical trial of laparoscopic versus robotic surgical learning curves., BJS Open
BACKGROUND: Minimally invasive surgery is the standard technique for many operations. Laparoscopic training has a long learning curve. Robotic solutions may shorten the training pathway. The aim of this study was to compare laparoscopic with robotic training in surgical trainees and medical students. METHODS: Surgical trainees (ST group) were randomized to receive 6 h of robotic or laparoscopic simulation training. They then performed three surgical tasks in cadaveric specimens. Medical students (MS group) had 2 h of robotic or laparoscopic simulation training followed by one surgical task. The Global Rating Scale (GRS) score (maximum 30), number of suture errors, and time to complete each procedure were recorded. RESULTS: The median GRS score for the ST group was better for each procedure after robotic training compared with laparoscopic training (total GRS score: 27·00 (i.q.r. 22·25-28·33) versus 18·00 (16·50-19·04) respectively, P < 0·001; 10 participants in each arm). The ST group made fewer errors in robotic than in laparoscopic tasks, for both continuous (7·00 (4·75-9·63) versus 22·25 (20·75-25·25); P < 0·001) and interrupted (8·25 (6·38-10·13) versus 29·50 (23·75-31·50); P < 0·001) sutures. For the MS group, the robotic group completed 8·67 interrupted sutures with 15·50 errors in 40 min, compared with only 3·50 sutures with 40·00 errors in the laparoscopic group (P < 0·001) (10 participants in each arm). Fatigue and physical comfort levels were better after robotic compared with laparoscopic operating for both groups (P < 0·001). CONCLUSION: The acquisition of surgical skills in surgical trainees and the surgically naive takes less time with a robotic compared with a l
Gavriilidis P, Sutcliffe RP, Roberts KJ, et al., 2020, No difference in mortality among ALPPS, two-staged hepatectomy, and portal vein embolization/ligation: A systematic review by updated traditional and network meta-analyses, HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, Vol: 19, Pages: 411-419, ISSN: 1499-3872
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- Citations: 1
Kawka M, Dawidziuk A, Jiao LR, et al., 2020, Artificial intelligence in the detection, characterisation and prediction of hepatocellular carcinoma: a narrative review, TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
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- Citations: 1
Kamarajah SK, Bundred J, Manas D, et al., 2020, Robotic Versus Conventional Laparoscopic Liver Resections: A Systematic Review and Meta-Analysis, SCANDINAVIAN JOURNAL OF SURGERY, Vol: 110, Pages: 290-300, ISSN: 1457-4969
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- Citations: 12
Sodergren MH, Mangal N, Wasan H, et al., 2020, Immunological combination treatment holds the key to improving survival in pancreatic cancer, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol: 146, Pages: 2897-2911, ISSN: 0171-5216
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- Citations: 8
Fang C, An J, Bruno A, et al., 2020, Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseases, Hepatology International, Vol: 14, Pages: 437-453, ISSN: 1936-0533
Three-dimensional (3D) visualization involves feature extraction and 3D reconstruction of CT images using a computer processing technology. It is a tool for displaying, describing, and interpreting 3D anatomy and morphological features of organs, thus providing intuitive, stereoscopic, and accurate methods for clinical decision-making. It has played an increasingly significant role in the diagnosis and management of liver diseases. Over the last decade, it has been proven safe and effective to use 3D simulation software for pre-hepatectomy assessment, virtual hepatectomy, and measurement of liver volumes in blood flow areas of the portal vein; meanwhile, the use of 3D models in combination with hydrodynamic analysis has become a novel non-invasive method for diagnosis and detection of portal hypertension. We herein describe the progress of research on 3D visualization, its workflow, current situation, challenges, opportunities, and its capacity to improve clinical decision-making, emphasizing its utility for patients with liver diseases. Current advances in modern imaging technologies have promised a further increase in diagnostic efficacy of liver diseases. For example, complex internal anatomy of the liver and detailed morphological features of liver lesions can be reflected from CT-based 3D models. A meta-analysis reported that the application of 3D visualization technology in the diagnosis and management of primary hepatocellular carcinoma has significant or extremely significant differences over the control group in terms of intraoperative blood loss, postoperative complications, recovery of postoperative liver function, operation time, hospitalization time, and tumor recurrence on short-term follow-up. However, the acquisition of high-quality CT images and the use of these images for 3D visualization processing lack a unified standard, quality control system, and homogeneity, which might hinder the evaluation of application efficacy in different clinical cente
COVIDSurg Collaborative, Jiao LR, 2020, Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study, The Lancet, Vol: 396, Pages: 27-38, ISSN: 0140-6736
BackgroundThe impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection.MethodsThis international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation.FindingsThis analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1&mi
Alsafi A, Jawad ZAR, Jiao LR, 2020, Percutaneous Trans-Jejunal Pancreatic Duct Drainage to Treat a Post-Operative Pancreatico-Cutaneous Fistula, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 43, Pages: 1564-1567, ISSN: 0174-1551
Sripadam R, Mukherjee S, Wadsley J, et al., 2020, ESPAC-5F: Four-arm, prospective, multicenter, international randomized phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Ghaneh P, Palmer DH, Cicconi S, et al., 2020, ESPAC-5F: Four-arm, prospective, multicenter, international randomized phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer., Journal of Clinical Oncology, Vol: 38, Pages: 4505-4505, ISSN: 0732-183X
<jats:p> 4505 </jats:p><jats:p> Background: Patients with borderline resectable pancreatic cancer have poor survival and low resection rates. Neoadjuvant therapy may improve the outcome for these patients. The aim of this trial was to determine the feasibility and efficacy of a comparison of immediate surgery versus neoadjuvant GEMCAP or FOLFIRINOX or CRT. Methods: Eligible patients with NCCN defined borderline resectable (following central review of the baseline CT scan) and biopsy proven pancreatic cancer were randomised (stratified by centre) to receive immediate surgery, or neoadjuvant therapy of either 2 cycles of GEMCAP, or 4 cycles of FOLFIRINOX or 50.4Gy capecitabine-based CRT in 28 daily fractions over 5 ½ weeks. Patients were restaged at 4-6 weeks and underwent surgical exploration if still borderline resectable. Resected patients received adjuvant therapy. Follow up was 12 months. There was quality assurance of surgery and CRT. Primary endpoints were recruitment rate and resection rate (R1/R0). Secondary endpoints included overall survival and toxicity. A target of 90 patients was set to determine feasibility and resection rates. Rates will be presented as point estimates and survival compared across treatment arms using a log-rank test. Analyses will be on an ITT basis. Results: Between August 2014 and December 2018, 90 patients were randomised with 88 included in the full analysis set (32 immediate surgery, 20 GEMCAP, 20 FOLFIRINOX, 16 CRT). Median age was 63 years, 44% were men. WHO performance status was 0 and 1 in 45% and 55% respectively. Median CA19-9 was 603 kU/L at baseline. 44 (79%) patients completed neoadjuvant therapy. Recruitment rate was 21 patients per year. Resection rate was 62% for immediate surgery and 55% for neoadjuvant therapy (p=0.668). R0 resection rate on resected patients was 15% and 23% respectively (p=0.721). One year survival rate was 40% [95% CI, 26% – 62%] for immediate surgery and 77% [95%CI
Kamarajah SK, Bundred JR, Marc OS, et al., 2020, A systematic review and network meta-analysis of different surgical approaches for pancreaticoduodenectomy, HPB, Vol: 22, Pages: 329-339, ISSN: 1365-182X
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- Citations: 18
Kamarajah SK, Bundred J, Saint Marc O, et al., 2020, Robotic versus conventional laparoscopic pancreaticoduodenectomy a systematic review and meta-analysis, EJSO, Vol: 46, Pages: 6-14, ISSN: 0748-7983
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- Citations: 34
Gall T, Alrawashdeh W, Soomro N, et al., 2019, Laparoscopic and robotic training in abdominal surgery: a randomised controlled trial, 22nd Annual Meeting of the Association-of-Upper-Gastrointestinal-Surgeons-of-Great-Britain-and-Ireland (AUGIS), Publisher: WILEY, Pages: 16-16, ISSN: 0007-1323
Saso S, Galazis N, Iacovou C, et al., 2019, Managing growing teratoma syndrome: new insights and clinical applications, FUTURE SCIENCE OA, Vol: 5, ISSN: 2056-5623
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- Citations: 1
Kamarajah SK, Bundred J, St Marc O, et al., 2019, A Systematic Review and Networked Meta-Analysis of Surgical Approach Techniques for Pancreaticoduodenectomy, International Surgical Conference of the Association-of-Surgeons-in-Training (ASIT), Publisher: WILEY, Pages: 19-19, ISSN: 0007-1323
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