Publications
334 results found
McGuigan C, Habib NA, Wasan HS, et al., 2011, A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine., J Clin Oncol, Vol: 29
e13540 Background: Resistance to gemcitabine is a major problem in the treatment of cancer. The key resistance mechanisms associated with gemcitabine are: lack of nucleoside transporters; lack of kinases for phosphorylation; and/or, rapid metabolism by deaminases. Resistance results in complete response rates of less than 10% in pancreatic cancer. The addition of a phosphoramidate ProTide moiety to gemcitabine enables: passive entry into the cell, by-passing the reliance on transporters; reduced reliance on kinases for phosphorylation; and, less susceptibility to deamination. METHODS: The ProTide (NUC-1031) was compared to the parent molecule (gemcitabine) in two pancreatic tumor xenograft models: Mia-Pa-Ca-2 (n=40), which is partially responsive to gemcitabine; and BxPC-3 (n=40), which is resistant. Two dose regimens for each tumor type were used, with NUC-1031 administered IP at doses of 0.076 or 0.19 mMol/kg when tumors had reached 150 - 200mm(3). The objective was to determine the ability of a novel agent (NUC-1031) to overcome gemcitabine resistance by measuring tumor growth in partially responsive and resistant pancreatic cell lines. RESULTS: The anti-tumor effect of NUC-1031 was greater and longer lasting than that of gemcitabine and control in both cell lines. NUC-1031 inhibition of tumor growth was significantly different from control in Mia-Pa-Ca-2 on days 4, 11, 14, 18, 21 and 25, and in BxPC-3 cells on days 25, 29, 33 and 37. In Mia-Pa-Ca-2 the tumor volume decreased immediately after first dosing and held at low levels until the end of the experiment. NUC-1031 was well tolerated and animals lost <2% body weight on treatment and this was regained rapidly after cessation of treatment. CONCLUSIONS: NUC-1031 showed statistically significant reduction in pancreatic tumor volume compared with gemcitabine and control. A phase I/II study of NUC-1031 in resistant/refractory pancreatic cancer is scheduled.
Skouras C, Purkayastha S, Jiao L, et al., 2011, Laparoscopic Management of Spigelian Hernias, SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, Vol: 21, Pages: 76-81, ISSN: 1530-4515
- Author Web Link
- Cite
- Citations: 17
Wadsworth CA, Ziprin P, Pelling MX, et al., 2011, A case of HGV-related epigastric pain, GUT, Vol: 60, Pages: 197-284, ISSN: 0017-5749
Steel AW, Postgate AJ, Khorsandi S, et al., 2011, Endoscopically applied radiofrequency ablation appears to be safe in the treatment of malignant biliary obstruction, GASTROINTESTINAL ENDOSCOPY, Vol: 73, Pages: 149-153, ISSN: 0016-5107
- Author Web Link
- Cite
- Citations: 212
Williamson JML, Thairu N, Katsoulas N, et al., 2010, Impact of portal vein embolization on expression of cancer stem cell markers in regenerated liver and colorectal liver metastases, SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol: 45, Pages: 1472-1479, ISSN: 0036-5521
- Author Web Link
- Cite
- Citations: 7
Ali SN, Goldstone T, Jiao L, et al., 2010, Multidisclipinary approach to managing multiple neuroendocrine tumours in MEN1, 18th International Symposium on Regulatory Peptides, Publisher: ELSEVIER SCIENCE BV, Pages: 16-17, ISSN: 0167-0115
Michaud DS, Vrieling A, Jiao L, et al., 2010, Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan), CANCER CAUSES & CONTROL, Vol: 21, Pages: 1213-1225, ISSN: 0957-5243
- Author Web Link
- Cite
- Citations: 80
Frampton AE, Bong JJ, Kyriakides C, et al., 2010, En bloc resection of the pancreatic head and second part of duodenum for a duodenal gastrointestinal stromal tumor: a multi-media report., JOP, Vol: 11, Pages: 396-400
Duodenal gastrointestinal stromal tumors are rare tumors. When these tumors arise from the second part of the duodenum they can easily be misdiagnosed as a pancreatic head cancer. A case of a 37-year-old female presenting with a one-year history of right upper quadrant pain is described here, who was subsequently found to have a mass in the head of the pancreas. Computed tomography scans showed a 2 cm hypervascular lesion lying between the head of pancreas and the second part of the duodenum, suggestive of a neuroendocrine tumor, and confirmed by endoscopic ultrasound scan. She underwent a pancreatic head resection with duodenal segmentectomy. Histopathological and immunohistochemical analysis revealed the tumor to be peri-ampullary duodenal gastrointestinal stromal tumor not invading the pancreas. Duodenal gastrointestinal stromal tumor can have a wide spectrum of clinical presentation. The accurate diagnosis of duodenal gastrointestinal stromal tumor is essential for determining the appropriate surgical intervention. In our case, a conservative surgical approach was utilised therefore avoiding a formal pancreaticoduodenectomy.
Jiao LR, Szydlo R, Habib NA, et al., 2010, Circulating Tumor Cells and Sample Size: The More, the Better Reply, JOURNAL OF CLINICAL ONCOLOGY, Vol: 28, Pages: E290-E290, ISSN: 0732-183X
- Author Web Link
- Cite
- Citations: 1
Curro G, Navarra G, Barbera A, et al., 2010, Concerns About Ultrasound-Guided Radiofrequency-Assisted Segmental Liver Resection <i>Reply</i>, ANNALS OF SURGERY, Vol: 251, Pages: 1192-1193, ISSN: 0003-4932
- Author Web Link
- Cite
- Citations: 2
Frampton AE, Castellano L, Tsim N, et al., 2010, MicroRNA expression profiles in pancreatic cystic tumors, JOURNAL OF CLINICAL ONCOLOGY, Vol: 28, ISSN: 0732-183X
Stebbing J, Farouk L, Panos G, et al., 2010, A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis, JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol: 44, Pages: 214-219, ISSN: 0192-0790
- Author Web Link
- Cite
- Citations: 163
Williamson JML, Westaby D, Stamp G, et al., 2010, A Rare Complex Association of Pancreatic Cystadenoma, PANCREAS, Vol: 39, Pages: 264-265, ISSN: 0885-3177
Tsim NC, Frampton AE, Habib NA, et al., 2010, Surgical treatment for liver cancer, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 16, Pages: 927-933, ISSN: 1007-9327
- Author Web Link
- Cite
- Citations: 48
Wickenden C, Castellano L, Jacob J, et al., 2010, No evidence for a viral association or aetiology in pancreatic cancer, MOLECULAR IMMUNOLOGY, Vol: 47, Pages: 639-639, ISSN: 0161-5890
- Author Web Link
- Cite
- Citations: 1
Jiao LR, Apostolopoulos C, Jacob J, et al., 2009, Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases, Journal of Clinical Oncology, Vol: 27, Pages: 6160-6165, ISSN: 0732-183X
PurposeThere are few data on the impact of immediate and differing surgical interventions on circulating tumorcells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites.Patients and MethodsCTCs from consecutive patients with colorectal liver metastases were quantified before andimmediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA), orpercutaneous RFA. For individuals undergoing open surgery, either hepatic resections or openRFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samplesderived from the peripheral vein, an artery, the hepatic portal vein, and the hepatic vein.ResultsA total of 29 consecutive patients with colorectal liver metastases with a median age of 55 years(range, 30 to 88 years) were included. CTCs were localized to the hepatic portosystemicmacrocirculation with significantly greater numbers than in the systemic vasculature. Surgicalprocedures led to a statistically significant fall in CTCs at multiple sites measured. Conversely,RFA, either open or percutaneous, was associated with a significant increase in CTCs.ConclusionSurgical resection of metastases, but not RFA, immediately decreases CTC levels. In patients withcolorectal liver metastases, CTCs appear localized to the hepatic (and pulmonary) macrocirculations.This may explain why metastases in sites other than the liver and lungs are infrequentlyobserved in cancer.
Sommerville CAM, Limongelli P, Pai M, et al., 2009, Survival Analysis After Pancreatic Resection for Ampullary and Pancreatic Head Carcinoma: An Analysis of Clinicopathological Factors, JOURNAL OF SURGICAL ONCOLOGY, Vol: 100, Pages: 651-656, ISSN: 0022-4790
- Author Web Link
- Cite
- Citations: 60
Stebbing J, Jiao LR, 2009, Circulating tumour cells as more than prognostic markers, LANCET ONCOLOGY, Vol: 10, Pages: 1138-1139, ISSN: 1470-2045
- Author Web Link
- Cite
- Citations: 11
Pai M, Helmy S, Jiao LR, et al., 2009, Clinical application of adult bone marrow-derived stem cell progenitors, Combined Meeting of the 17th European-Society-of-Gene-and-Cell-Therapy/16th German-Society-for-Gene-Therapy/4th German-Society-for-Stem-Cell-Research, Publisher: MARY ANN LIEBERT INC, Pages: 1367-1367, ISSN: 1043-0342
Castellano L, Giamas G, Jacob J, et al., 2009, The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 15732-15737, ISSN: 0027-8424
- Author Web Link
- Cite
- Citations: 282
Curro G, Bartolotta M, Jiao L, et al., 2009, Ultrasound-guided radiofrequency-assisted segmental liver resection: a new technique., Annals of Surgery, Vol: 250, Pages: 229-33
Zacharoulis D, Khorsandi SE, Vavra P, et al., 2009, Pilot study for a new bipolar radiofrequency ablation/aspirator device in the management of primary and secondary liver cancers, LIVER INTERNATIONAL, Vol: 29, Pages: 824-830, ISSN: 1478-3223
- Author Web Link
- Cite
- Citations: 10
Jiao L, Apostolopoulos C, Jacob J, et al., 2009, The anatomic localization of circulating tumor cells and the immediate impact of surgery and radiofrequency ablation., J Clin Oncol, Vol: 27
e22004 Background: There are few data on the impact of immediate and differing surgical interventions on circulating tumor cells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites. METHODS: CTCs from consecutive patients with colorectal liver metastases were quantitated prior to and immediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA) or percutaneous RFA. For individuals undergoing open surgery, either hepatic resections or open RFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samples derived from the peripheral vein, an artery, the portal vein and hepatic vein. RESULTS: A total of 29 consecutive patients with colorectal liver metastases were included with a median age of 55 (range 30 - 88 years). CTCs were localized to the hepatic portosystemic macrocirculation with significantly greater numbers than in the systemic vasculature. Surgical procedures led to a statistically significant fall in CTCs at all sites measured (p<0.05). Conversely, RFA, either open or percutaneous was associated with an increase in CTCs. CONCLUSIONS: Surgical resection of metastases but not RFA decreases CTC levels. In patients with colorectal liver metastases, CTCs are localized to the hepatic (and probably pulmonary) macrocirculations. This may explain why metastases in sites other than the liver and lungs, are infrequently observed in cancer. No significant financial relationships to disclose.
Stebbing J, Wong N, Tan L, et al., 2009, The Relationship Between Prolonged Antiretroviral Therapy and Cryptogenic Liver Disease, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 50, Pages: 554-556, ISSN: 1525-4135
- Author Web Link
- Cite
- Citations: 3
Limongelli P, Pai M, Damrah O, et al., 2009, Cystic Tumors of the Biliary Tract: A Complete Excision Is Crucial, INTERNATIONAL SURGERY, Vol: 94, Pages: 136-140, ISSN: 0020-8868
- Author Web Link
- Cite
- Citations: 5
Giamas G, Castellano L, Feng Q, et al., 2009, CK1{delta} modulates the transcriptional activity of ER{alpha} via AIB1 in an estrogen-dependent manner and regulates ER{alpha}-AIB1 interactions., Nucleic Acids Res.
Payne RE, Yaguee E, Slade MJ, et al., 2009, Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients, PHARMACOGENOMICS, Vol: 10, Pages: 51-57, ISSN: 1462-2416
- Author Web Link
- Cite
- Citations: 53
Windsor ACJ, Cohen R, Jiao LR, et al., 2008, Cetuximab in the first-line therapy of metastatic colorectal carcinoma: not so CRYSTAL clear, FUTURE ONCOLOGY, Vol: 4, Pages: 741-744, ISSN: 1479-6694
- Author Web Link
- Cite
- Citations: 5
Curro G, Jiao L, Baccarani U, et al., 2008, Radiofrequency-assisted liver resection in cirrhotic patients with hepatocellular carcinoma, Journal of Surgical Oncology, Vol: 98, Pages: 407-410
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.