Imperial College London

MrLewisKeeble

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Research Postgraduate
 
 
 
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Contact

 

l.keeble18

 
 
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Location

 

B422Bessemer BuildingSouth Kensington Campus

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Summary

 

Summary

The research that I am conducting as a PhD student at the Centre for Bio-Inspired Technology focusses on providing a signal boost for ISFET arrays in their detection of amplifying DNA through use of electric fields to manipulate DNA strands. Dielectrophoresis forms the basis of this technique, where the electric dipole of DNA experiences imbalanced electrostatic forces when in a spatially inhomogeneous field. This allows the use of microfabricated electrodes integrated with the CMOS platform of the ISFET array to draw DNA towards the sensor surface and ensure that the protons production during strand growth is localised leading to a greater likelihood of detecting the ions. In addition, there are many stages of sample preparation, such as sorting and concentration, which could be conducted on chip by electrodes using dielectrophoresis.

I joined Imperial in 2018 after being awarded a 4 year scholarship with the HiPEDS CDT, under the supervision of Dr. Pantelis Georgiou and Dr. Jesus Rodriguez-Manzano. This came after completing an integrated Masters in Physics (MPhys) at the University of Manchester. My master's project investigated the use of microwave resonators to measure blood glucose levels non-invasively, working as part of the advanced technology group. I was awarded the 2017/18 Platt prize for outstanding experimental work in my master's project.