Imperial College London
Portrait Picture

Prof Liz Lightstone

Faculty of Medicine, Department of Immunology and Inflammation

Proconsul and Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 3152l.lightstone Website CV

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wiles:2020:10.2215/CJN.15121219,
author = {Wiles, K and Chappell, LC and Lightstone, L and Bramham, K},
doi = {10.2215/CJN.15121219},
journal = {Clinical Journal of the American Society of Nephrology},
pages = {1371--1380},
title = {Updates in diagnosis and management of preeclampsia in women with CKD.},
url = {http://dx.doi.org/10.2215/CJN.15121219},
volume = {15},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is estimated that women with CKD are ten times more likely to develop preeclampsia than women without CKD, with preeclampsia affecting up to 40% of pregnancies in women with CKD. However, the shared phenotype of hypertension, proteinuria, and impaired excretory kidney function complicates the diagnosis of superimposed preeclampsia in women with CKD who have hypertension and/or proteinuria that predates pregnancy. This article outlines the diagnoses of preeclampsia and superimposed preeclampsia. It discusses the pathogenesis of preeclampsia, including abnormal placentation and angiogenic dysfunction. The clinical use of angiogenic markers as diagnostic adjuncts for women with suspected preeclampsia is described, and the limited data on the use of these markers in women with CKD are presented. The role of kidney biopsy in pregnancy is examined. The management of preeclampsia is outlined, including important advances and controversies in aspirin prophylaxis, BP treatment targets, and the timing of delivery.
AU  - Wiles,K
AU  - Chappell,LC
AU  - Lightstone,L
AU  - Bramham,K
DO  - 10.2215/CJN.15121219
EP  - 1380
PY  - 2020///
SN  - 1555-9041
SP  - 1371
TI  - Updates in diagnosis and management of preeclampsia in women with CKD.
T2  - Clinical Journal of the American Society of Nephrology
UR  - http://dx.doi.org/10.2215/CJN.15121219
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32241779
UR  - https://cjasn.asnjournals.org/
UR  - http://hdl.handle.net/10044/1/83012
VL  - 15
ER  -
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