Imperial College London
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Prof Liz Lightstone

Faculty of Medicine, Department of Immunology and Inflammation

Proconsul and Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 3152l.lightstone Website CV

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clarke:2021:10.1016/j.ekir.2020.10.032,
author = {Clarke, C and Lucisano, G and Prendecki, M and Gleeson, S and Martin, P and Ali, M and McAdoo, SP and Lightstone, L and Ashby, D and Charif, R and Griffith, M and McLean, A and Dor, F and Willicombe, M and ICHNT, Renal COVID Group},
doi = {10.1016/j.ekir.2020.10.032},
journal = {Kidney International Reports},
pages = {46--55},
title = {Informing the risk of kidney transplantation versus remaining on the wait list in the COVID-19 era},
url = {http://dx.doi.org/10.1016/j.ekir.2020.10.032},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: There is limited data pertaining to comparative outcomes of remaining on dialysis versus kidney transplantation as the threat of COVID-19 remains. This study aims to delineate the differential risks involved using serological methods to help define exposure rates. Methods: From a cohort of 1433 patients with ESKD, we analysed COVID-19 infection rates and outcomes in 299 wait list patients compared with 237 transplant recipients within their first year post-transplant. Patients were followed over a 68-day period from the time our transplant programme closed due to COVID-19. Results: The overall mortality rate in wait list and transplant populations were equivalent, p=0.69. However, COVID-19 infection was more commonly diagnosed in the wait list patients, p=0.001, who were more likely to be tested by RT-PCR, p=0.0004. Once infection was confirmed, mortality risk was higher in the transplant patients, p=0.015. The seroprevalence in dialysis and transplant patients with undetected infection was 18.3% and 4.6% respectively, p=0.0001. After adjusting for a potential screening bias, the relative risk of death following a diagnosis of COVID-19 remained higher in transplant recipients, HR: 3.36 (1.19-9.50), p=0.022. Conclusions: In conclusion, whilst COVID-19 infection was more common in the wait list patients, a higher COVID-19 associated mortality rate was seen in transplant recipients, resulting in comparable overall mortality rates.
AU  - Clarke,C
AU  - Lucisano,G
AU  - Prendecki,M
AU  - Gleeson,S
AU  - Martin,P
AU  - Ali,M
AU  - McAdoo,SP
AU  - Lightstone,L
AU  - Ashby,D
AU  - Charif,R
AU  - Griffith,M
AU  - McLean,A
AU  - Dor,F
AU  - Willicombe,M
AU  - ICHNT,Renal COVID Group
DO  - 10.1016/j.ekir.2020.10.032
EP  - 55
PY  - 2021///
SN  - 2468-0249
SP  - 46
TI  - Informing the risk of kidney transplantation versus remaining on the wait list in the COVID-19 era
T2  - Kidney International Reports
UR  - http://dx.doi.org/10.1016/j.ekir.2020.10.032
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33173838
UR  - https://www.sciencedirect.com/science/article/pii/S2468024920317034?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84061
VL  - 6
ER  -
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