Imperial College London
Portrait Picture

Prof Liz Lightstone

Faculty of Medicine, Department of Immunology and Inflammation

Proconsul and Professor of Renal Medicine
 
 
 
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Contact

 

+44 (0)20 3313 3152l.lightstone Website CV

 
 
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Assistant

 

Miss Anjli Jagpal +44 (0)20 3313 3152

 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{McAuley:2023:10.1016/j.eclinm.2023.101896,
author = {McAuley, HJC and Evans, RA and Bolton, CE and Brightling, CE and Chalmers, JD and Docherty, AB and Elneima, O and Greenhaff, PL and Gupta, A and Harris, VC and Harrison, EM and Ho, L-P and Horsley, A and Houchen-Wolloff, L and Jolley, CJ and Leavy, OC and Lone, NI and Man, WD-C and Marks, M and Parekh, D and Poinasamy, K and Quint, JK and Raman, B and Richardson, M and Saunders, RM and Sereno, M and Shikotra, A and Singapuri, A and Singh, SJ and Steiner, M and Tan, AL and Wain, LV and Welch, C and Whitney, J and Witham, MD and Lord, J and Greening, NJ and PHOSP-COVID, Study Collaborative Group},
doi = {10.1016/j.eclinm.2023.101896},
journal = {EClinicalMedicine},
pages = {1--13},
title = {Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.},
url = {http://dx.doi.org/10.1016/j.eclinm.2023.101896},
volume = {57},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. METHODS: This prospective cohort study recruited adults who had survived hospitalisation with clinically diagnosed COVID-19 across 35 sites in the UK (PHOSP-COVID). The burden of frailty was objectively measured using Fried's Frailty Phenotype (FFP). The primary outcome was the prevalence of each FFP group-robust (no FFP criteria), pre-frail (one or two FFP criteria) and frail (three or more FFP criteria)-at 5 months and 1 year after discharge from hospital. For inclusion in the primary analysis, participants required complete outcome data for three of the five FFP criteria. Longitudinal changes across frailty domains are reported at 5 months and 1 year post-hospitalisation, along with risk factors for frailty status. Patient-perceived recovery and health-related quality of life (HRQoL) were retrospectively rated for pre-COVID-19 and prospectively rated at the 5 month and 1 year visits. This study is registered with ISRCTN, number ISRCTN10980107. FINDINGS: Between March 5, 2020, and March 31, 2021, 2419 participants were enrolled with FFP data. Mean age was 57.9 (SD 12.6) years, 933 (38.6%) were female, and 429 (17.7%) had received invasive mechanical ventilation. 1785 had measures at both timepoints, of which 240 (13.4%), 1138 (63.8%) and 407 (22.8%) were frail, pre-frail and robust, respectively, at 5 months compared with 123 (6.9%), 1046 (58.6%) and 616 (34.5%) at 1 year. Factors associated with pre-frailty or frailty were invasive mechanical ventilation, older age, female sex, and greater social deprivation. Frail participants had a larger reduction in HRQoL compared with before their COVID-19 illness and were less likely to describe themselves as recovered. INTERPRETATION: Physical frailty and pre-frailty are common following hospitalisation with COVID-19. Improvement in frailty was seen between 5 and 12 months although
AU  - McAuley,HJC
AU  - Evans,RA
AU  - Bolton,CE
AU  - Brightling,CE
AU  - Chalmers,JD
AU  - Docherty,AB
AU  - Elneima,O
AU  - Greenhaff,PL
AU  - Gupta,A
AU  - Harris,VC
AU  - Harrison,EM
AU  - Ho,L-P
AU  - Horsley,A
AU  - Houchen-Wolloff,L
AU  - Jolley,CJ
AU  - Leavy,OC
AU  - Lone,NI
AU  - Man,WD-C
AU  - Marks,M
AU  - Parekh,D
AU  - Poinasamy,K
AU  - Quint,JK
AU  - Raman,B
AU  - Richardson,M
AU  - Saunders,RM
AU  - Sereno,M
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Singh,SJ
AU  - Steiner,M
AU  - Tan,AL
AU  - Wain,LV
AU  - Welch,C
AU  - Whitney,J
AU  - Witham,MD
AU  - Lord,J
AU  - Greening,NJ
AU  - PHOSP-COVID,Study Collaborative Group
DO  - 10.1016/j.eclinm.2023.101896
EP  - 13
PY  - 2023///
SN  - 2589-5370
SP  - 1
TI  - Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.
T2  - EClinicalMedicine
UR  - http://dx.doi.org/10.1016/j.eclinm.2023.101896
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36936404
UR  - https://www.sciencedirect.com/science/article/pii/S2589537023000731
UR  - http://hdl.handle.net/10044/1/102997
VL  - 57
ER  -
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