Imperial College London
Alternate

ProfessorLucaMagnani

Faculty of Medicine, Department of Surgery & Cancer

Honorary Principal Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 2808l.magnani CV

 
 
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Location

 

137ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Magnani:2017:10.1007/978-3-319-48848-6_3,
author = {Magnani, L and Patten, DK},
booktitle = {Breast Cancer: Innovations in Research and Management},
doi = {10.1007/978-3-319-48848-6_3},
pages = {19--26},
title = {Fundamental pathways in breast cancer 3: Estrogen biology},
url = {http://dx.doi.org/10.1007/978-3-319-48848-6_3},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Over the last two decades, it has become evident that breast cancer should be considered as a family of diseases rather than as a unique malignancy. Pathological, molecular, and genetic analysis have revealed the existence of five to ten main subgroups [1-3]. Over 70% of all patients are generally classified by the tumor dependencies on estrogenic compounds [4]. These dependencies are principally mediated by the nuclear receptor estrogen receptor a (ERa) [5, 6]. For all these reasons, ERa remains the key driver in the majority of breast cancers and is commonly used as a molecular biomarker for stratification while serving as the main target for systemic adjuvant chemotherapy. In this chapter I will discuss the molecular mechanisms of ERa activation focusing on integrative analysis that have recently exposed the intimate link between ERa and chromatin structure.
AU  - Magnani,L
AU  - Patten,DK
DO  - 10.1007/978-3-319-48848-6_3
EP  - 26
PY  - 2017///
SN  - 9783319488462
SP  - 19
TI  - Fundamental pathways in breast cancer 3: Estrogen biology
T1  - Breast Cancer: Innovations in Research and Management
UR  - http://dx.doi.org/10.1007/978-3-319-48848-6_3
ER  -
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