DrLauraMartinez Gili

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Fellow

Contact

l.martinez-gili Website

Location

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

Summary

I am a non-clinical biomedical scientist with a multidisciplinary background in cell biology and bioinformatics.

Metabolic alterations occurring in different diseases have been the focus of my work. During my PhD at University of Barcelona (UB), I characterised the contribution of different lipid species, mainly free fatty acids, sphingolipids and cholesterol, in liver pathologies and Alzheimer's disease. During my postdoc at Imperial College I switched to a more holistic approach by using state of the art metabolomics, metagenomics and systems biology to study host-microbiome interactions in neurodevelopmental disorders, and explore the mechanisms by which gut microbiota and its metabolites influence diseases.

Currently, I am part of the BRC Gut Health Theme. I combine different omics (metabolomics, metagenomics) and computational tools to identify novel prognostic biomarkers that could be used to improve patient stratification with respect to clinical outcome and prognosis (remission, gut permeability, inflammation) and to develop and validate new therapies for inflammatory bowel disease (IBD) and other gastrointestinal conditions.

Publications

Journals

Routy B, Lenehan JG, Miller WH, et al.Routy B, Lenehan JG, Miller WH, Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Punčochář M, Ernst S, Logan D, Belanger K, Esfahani K, Richard C, Ninkov M, Piccinno G, Armanini F, Pinto F, Krishnamoorthy M, Figueredo R, Thebault P, Takis P, Magrill J, Ramsay L, Derosa L, Marchesi JR, Parvathy SN, Elkrief A, Watson IR, Lapointe R, Segata N, Haeryfar SMM, Mullish BH, Silverman MS, Burton JP, Maleki Vareki S close, 2023, Author Correction: Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial., Nat Med

Andrikopoulos P, Aron-Wisnewsky J, Chakaroun R, et al.Andrikopoulos P, Aron-Wisnewsky J, Chakaroun R, Myridakis A, Forslund S, Nielsen T, Adriouch S, Holmes B, Chilloux J, Vieira-Silva S, Falony G, Salem J-E, Andreelli F, Belda E, Kieswich J, Chechi K, Puig-Castellvi F, Chevalier M, Le Chatelier E, Olanipekun M, Hoyles L, Alves R, Helft G, Isnard R, Køber L, Coelho LP, Rouault C, Gauguier D, Gøtze JP, Prifti E, Froguel P, The MetaCardis C, Zucker J-D, Bäckhed F, Vestergaard H, Hansen T, Oppert J-M, Blüher M, Nielsen J, Raes J, Bork P, Yaqoob M, Stumvoll M, Pedersen O, Ehrlich SD, Clément K, Dumas M-E close, 2023, Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-18

Routy B, Lenehan JG, Miller WH, et al.Routy B, Lenehan JG, Miller WH, Jamal R, Messaoudene M, Daisley BA, Hes C, Al KF, Martinez-Gili L, Punčochář M, Ernst S, Logan D, Belanger K, Esfahani K, Richard C, Ninkov M, Piccinno G, Armanini F, Pinto F, Krishnamoorthy M, Figueredo R, Thebault P, Takis P, Magrill J, Ramsay L, Derosa L, Marchesi JR, Parvathy SN, Elkrief A, Watson IR, Lapointe R, Segata N, Haeryfar SMM, Mullish BH, Silverman MS, Burton JP, Maleki Vareki S close, 2023, Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial, Nature Medicine, ISSN:1546-170X

Conference

Balarajah S, Martinez-Gili L, Alexander J, et al.Balarajah S, Martinez-Gili L, Alexander J, Orchard T, Hicks L, Williams H close, 2023, The South Asian inflammatory bowel disease (IBD) phenotype: ethnic differences demonstrated through analysis of the UK IBD BioResource database, Annual Meeting of the British-Society-of-Gastroenterology (BSG), BMJ PUBLISHING GROUP, Pages:A72-A72, ISSN:0017-5749

Forlano R, Martinez-Gili L, Blanco JM, et al.Forlano R, Martinez-Gili L, Blanco JM, Skinner C, Thursz M, Marchesi J close, 2023, Altered gut barrier integrity as a mediator of host-microbiome interactions in diabetic patients with advanced Non-alcoholic fatty liver disease, ELSEVIER, Pages:S601-S602, ISSN:0168-8278

Author Web Link

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