Publications
250 results found
Lee SH, Ripke S, Neale BM, et al., 2013, Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs, NATURE GENETICS, Vol: 45, Pages: 984-+, ISSN: 1061-4036
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- Citations: 1584
Steffen A, Sorensen TIA, Knueppel S, et al., 2013, Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 13
Marcano Belisario JS, Tudor KI, Sumalinog ARN, et al., 2013, Educational interventions for improving the skills of medical practitioners to detect, diagnose, and manage people with cognitive impairment and dementia [Intervention Protocol], Cochrane Database of Systematic Reviews
Chan KY, Wang W, Wu JJ, et al., 2013, Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis, LANCET, Vol: 381, Pages: 2016-2023, ISSN: 0140-6736
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- Citations: 512
Kakkos SK, Griffin MB, Nicolaides AN, et al., 2013, The size of juxtaluminal hypoechoic area in ultrasound images of asymptomatic carotid plaques predicts the occurrence of stroke, JOURNAL OF VASCULAR SURGERY, Vol: 57, Pages: 609-617, ISSN: 0741-5214
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- Citations: 123
Gallo V, Wark PA, Jenab M, et al., 2013, Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis The EPIC cohort, NEUROLOGY, Vol: 80, Pages: 829-838, ISSN: 0028-3878
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- Citations: 100
Nicolaou P, Cianchetti C, Minaidou A, et al., 2013, A novel <i>LRSAM1</i> mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 21, Pages: 190-194, ISSN: 1018-4813
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- Citations: 25
Ruffmann C, Bravi I, Calboli FCF, et al., 2012, Dementia in Lewy body disorders: clinicopathological correlations in a large sample from the Parkinson's UK Tissue Bank, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 72-72, ISSN: 1351-5101
Kakkos SK, Griffin MB, Nicolaides AN, et al., 2012, The Size of Juxtaluminal Black Area in Ultrasonic Images of Asymptomatic Carotid Plaques Predicts the Occurrence of Stroke, Vascular Annual Meeting of the Society-for-Vascular-Surgery (SVS), Publisher: MOSBY-ELSEVIER, Pages: 84-85, ISSN: 0741-5214
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- Citations: 3
Christou YP, Nicolaou P, Kleopa K, et al., 2012, Variable phenotypes caused by the PMP22 S22F point mutation, 22nd Meeting of the European-Neurological-Society, Publisher: SPRINGER HEIDELBERG, Pages: S123-S123, ISSN: 0340-5354
Breen G, Webb BT, Butler AW, et al., 2011, A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study, AMERICAN JOURNAL OF PSYCHIATRY, Vol: 168, Pages: 840-847, ISSN: 0002-953X
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- Citations: 47
Breen G, Webb BT, Butler AW, et al., 2011, A genome-wide significant linkage for severe depression on chromosome 3: the depression network study., Am J Psychiatry, Vol: 168, Pages: 840-847
OBJECTIVE: The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample. METHOD: The authors conducted a genome-wide linkage analysis of 839 families consisting of 971 affected sibling pairs with severe recurrent major depression, comprising waves I and II of the Depression Network Study cohort. In addition to examining affected status, linkage analyses in the full data set were performed using diagnoses restricted by impairment severity, and association mapping of hits in a large case-control data set was attempted. RESULTS: The authors identified genome-wide significant linkage to chromosome 3p25-26 when the diagnoses were restricted by severity, which was a maximum LOD score of 4.0 centered at the linkage marker D3S1515. The linkage signal identified was genome-wide significant after correction for the multiple phenotypes tested, although subsequent association mapping of the region in a genome-wide association study of a U.K. depression sample did not provide significant results. CONCLUSIONS: The authors report a genome-wide significant locus for depression that implicates genes that are highly plausible for involvement in the etiology of recurrent depression. Despite the fact that association mapping in the region was negative, the linkage finding was replicated by another group who found genome-wide-significant linkage for depression in the same region. This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication.
Butler AW, Breen G, Tozzi F, et al., 2010, A Genomewide Linkage Study on Suicidality in Major Depressive Disorder Confirms Evidence for Linkage to 2p12, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, Vol: 153B, Pages: 1465-1473, ISSN: 1552-4841
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- Citations: 24
Spencer JP, Middleton LJ, Davies CH, 2010, Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices, NEUROPHARMACOLOGY, Vol: 59, Pages: 437-443, ISSN: 0028-3908
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- Citations: 26
Jasinska-Myga B, Kachergus J, Vilarino-Gueell C, et al., 2010, Comprehensive Sequencing of the <i>LRRK2</i> Gene in Patients with Familial Parkinson's Disease from North Africa, MOVEMENT DISORDERS, Vol: 25, Pages: 2052-2058, ISSN: 0885-3185
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- Citations: 15
Votsi C, Nicolaou P, Georghiou A, et al., 2010, Investigation of sporadic ataxia patients in the Cypriot population, 14th Congress of European-Federation-of-Neurological-Societies, Publisher: WILEY-BLACKWELL, Pages: 605-605, ISSN: 1351-5101
Ozcelik T, Kanaan M, Avraham KB, et al., 2010, Collaborative genomics for human health and cooperation in the Mediterranean region, NATURE GENETICS, Vol: 42, Pages: 641-645, ISSN: 1061-4036
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- Citations: 21
Kasperaviciute D, Catarino CB, Heinzen EL, et al., 2010, Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study, Brain, Vol: 133, Pages: 2136-2147, ISSN: 1460-2156
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio <1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.
Muglia P, Tozzi F, Galwey NW, et al., 2010, Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts, MOLECULAR PSYCHIATRY, Vol: 15, Pages: 589-601, ISSN: 1359-4184
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- Citations: 181
Heinzen EL, Radtke RA, Urban TJ, et al., 2010, Rare Deletions at 16p13.11 Predispose to a Diverse Spectrum of Sporadic Epilepsy Syndromes, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 86, Pages: 707-718, ISSN: 0002-9297
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- Citations: 201
Liu JZ, Tozzi F, Waterworth DM, et al., 2010, Meta-analysis and imputation refines the association of 15q25 with smoking quantity, NATURE GENETICS, Vol: 42, Pages: 436-U75, ISSN: 1061-4036
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- Citations: 492
Nishioka K, Kefi M, Jasinska-Myga B, et al., 2010, A comparative study of <i>LRRK2</i>, <i>PINK1</i> and genetically undefined familial Parkinson's disease, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 81, Pages: 391-395, ISSN: 0022-3050
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- Citations: 36
Domenici E, Wille DR, Tozzi F, et al., 2010, Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections, PLOS ONE, Vol: 5, ISSN: 1932-6203
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- Citations: 267
Gallo V, Vineis P, Riboli E, et al., 2009, The large- scale European prospective investigation into cancer and nutrition (EPIC) unravels risk factors for ALS, 13th Congress of the European-Federation-of-Neurological-Societies, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 218-218, ISSN: 1351-5101
Ball HA, Samaan Z, Brewster S, et al., 2009, Depression, migraine with aura and migraine without aura: their familiality and interrelatedness, CEPHALALGIA, Vol: 29, Pages: 848-854, ISSN: 0333-1024
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- Citations: 8
Kyriacou K, Kassianides B, Hadjisavvas A, et al., 2009, The role of electron microscopy in the diagnosis of nonneoplastic muscle diseases, ULTRASTRUCTURAL PATHOLOGY, Vol: 21, Pages: 243-252, ISSN: 0191-3123
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- Citations: 2
Kyriacou K, Mikellidou C, Hadjianastasiou A, et al., 2009, Ultrastructural diagnosis of mitochondrial encephalomyopathies revisited, ULTRASTRUCTURAL PATHOLOGY, Vol: 23, Pages: 163-170, ISSN: 0191-3123
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- Citations: 11
Scott LJ, Muglia P, Kong XQ, et al., 2009, Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 7501-7506, ISSN: 0027-8424
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- Citations: 222
Lin X, Song K, Lim N, et al., 2009, Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score-the CoLaus Study, DIABETOLOGIA, Vol: 52, Pages: 600-608, ISSN: 0012-186X
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- Citations: 94
Preisig M, Waeber G, Vollenweider P, et al., 2009, The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors, BMC PSYCHIATRY, Vol: 9, ISSN: 1471-244X
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- Citations: 147
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