Imperial College London
Alternate

Professor Lefkos Middleton

Faculty of Medicine, School of Public Health

Chair in Clinical Neurology
 
 
 
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Contact

 

+44 (0)20 3311 7290l.middleton CV

 
 
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Assistant

 

Ms Naia Headland-Vanni +44 (0)20 3311 7290

 
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Location

 

Room 10L05 LaboratoryCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Riso:2019:10.1016/j.parkreldis.2019.01.019,
author = {Riso, L and Kaaks, R and Kühn, T and Sookthai, D and Forsgren, L and Trupp, M and Trichopoulou, A and La, Vecchia C and Karakatsani, A and Gavrila, D and Ferrari, P and Freisling, H and Petersson, J and Lewan, S and Vermeulen, RC and Panico, S and Masala, G and Ardanaz, E and Krogh, V and Perneczky, RG and Middleton, LT and Mokoroa, O and Sacerdote, C and Sieri, S and Hayat, SA and Brayne, C and Riboli, E and Vineis, P and Gallo, V and Katzke, VA},
doi = {10.1016/j.parkreldis.2019.01.019},
journal = {Parkinsonism and Related Disorders},
pages = {98--104},
title = {General and abdominal adiposity and the risk of parkinson's disease.A prospective chort study},
url = {http://dx.doi.org/10.1016/j.parkreldis.2019.01.019},
volume = {62},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionDue to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.MethodsIn 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking.ResultsWe found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD.ConclusionOur data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
AU  - Riso,L
AU  - Kaaks,R
AU  - Kühn,T
AU  - Sookthai,D
AU  - Forsgren,L
AU  - Trupp,M
AU  - Trichopoulou,A
AU  - La,Vecchia C
AU  - Karakatsani,A
AU  - Gavrila,D
AU  - Ferrari,P
AU  - Freisling,H
AU  - Petersson,J
AU  - Lewan,S
AU  - Vermeulen,RC
AU  - Panico,S
AU  - Masala,G
AU  - Ardanaz,E
AU  - Krogh,V
AU  - Perneczky,RG
AU  - Middleton,LT
AU  - Mokoroa,O
AU  - Sacerdote,C
AU  - Sieri,S
AU  - Hayat,SA
AU  - Brayne,C
AU  - Riboli,E
AU  - Vineis,P
AU  - Gallo,V
AU  - Katzke,VA
DO  - 10.1016/j.parkreldis.2019.01.019
EP  - 104
PY  - 2019///
SN  - 1353-8020
SP  - 98
TI  - General and abdominal adiposity and the risk of parkinson's disease.A prospective chort study
T2  - Parkinsonism and Related Disorders
UR  - http://dx.doi.org/10.1016/j.parkreldis.2019.01.019
UR  - https://www.sciencedirect.com/science/article/pii/S1353802019300197?via%3Dihub
UR  - http://hdl.handle.net/10044/1/67474
VL  - 62
ER  -
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