Imperial College London
Alternate

Professor Lefkos Middleton

Faculty of Medicine, School of Public Health

Chair in Clinical Neurology
 
 
 
//

Contact

 

+44 (0)20 3311 7290l.middleton CV

 
 
//

Assistant

 

Ms Naia Headland-Vanni +44 (0)20 3311 7290

 
//

Location

 

Room 10L05 LaboratoryCharing Cross HospitalCharing Cross Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Takousis:2019:10.1016/j.jalz.2019.06.4952,
author = {Takousis, P and Sadlon, A and Schulz, J and Wohlers, I and Dobricic, V and Middleton, L and Lill, CM and Perneczky, R and Bertram, L},
doi = {10.1016/j.jalz.2019.06.4952},
journal = {Alzheimers & Dementia},
pages = {1468--1477},
title = {Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid},
url = {http://dx.doi.org/10.1016/j.jalz.2019.06.4952},
volume = {15},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Several microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case-control studies remains inconclusive. METHODS: A systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal fluid specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty. RESULTS: Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10-4) in brain, cerebrospinal fluid, and blood-derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. Of these 57 miRNAs, 13 had not been reported in the abstracts of previous original or review articles. DISCUSSION: Our systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance.
AU  - Takousis,P
AU  - Sadlon,A
AU  - Schulz,J
AU  - Wohlers,I
AU  - Dobricic,V
AU  - Middleton,L
AU  - Lill,CM
AU  - Perneczky,R
AU  - Bertram,L
DO  - 10.1016/j.jalz.2019.06.4952
EP  - 1477
PY  - 2019///
SN  - 1552-5260
SP  - 1468
TI  - Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid
T2  - Alzheimers & Dementia
UR  - http://dx.doi.org/10.1016/j.jalz.2019.06.4952
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31495604
UR  - https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2019.06.4952
UR  - http://hdl.handle.net/10044/1/73458
VL  - 15
ER  -
Download