Imperial College London
Alternate

Professor Lefkos Middleton

Faculty of Medicine, School of Public Health

Chair in Clinical Neurology
 
 
 
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Contact

 

+44 (0)20 3311 7290l.middleton CV

 
 
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Assistant

 

Ms Naia Headland-Vanni +44 (0)20 3311 7290

 
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Location

 

Room 10L05 LaboratoryCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zheng:2020:10.1016/j.arr.2020.101171,
author = {Zheng, B and Tal, R and Yang, Z and Middleton, L and Udeh-Momoh, C},
doi = {10.1016/j.arr.2020.101171},
journal = {Ageing Research Reviews},
pages = {1--11},
title = {Cortisol hypersecretion and the risk of Alzheimer’s disease: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1016/j.arr.2020.101171},
volume = {64},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMorning cortisol levels have been reported to be elevated among patients with Alzheimer’s disease (AD); yet no meta-analysis has been conducted to confirm the existence and magnitude of this association. It also remains unclear whether hypercortisolism is a risk factor for AD.MethodsPubMed, EMBASE, and PsycINFO were systematically searched for eligible studies. Cross-sectional data were pooled using random-effects meta-analyses; the differences in morning cortisol levels between patients and cognitively normal controls were quantified. Longitudinal studies were qualitatively synthesised due to methodological heterogeneity.Results17,245 participants from 57 cross-sectional studies and 19 prospective cohort studies were included. Compared with cognitively normal controls, AD patients had moderately increased morning cortisol in blood (g = 0.422, P < 0.001; I2 = 48.5 %), saliva (g = 0.540, P < 0.001; I2 = 13.6 %), and cerebrospinal fluids (g = 0.565, P = 0.003; I2 = 75.3 %). A moderate elevation of morning cortisol was also detected in cerebrospinal fluids from patients with mild cognitive impairment (MCI) versus controls (g = 0.309, P = 0.001; I2 = 0.0 %). Cohort studies suggested that higher morning cortisol may accelerate cognitive decline in MCI or mild AD patients, but the results in cognitively healthy adults were inconsistent.ConclusionsMorning cortisol was confirmed to be moderately elevated in AD patients and may have diagnostic and prognostic values for AD.
AU  - Zheng,B
AU  - Tal,R
AU  - Yang,Z
AU  - Middleton,L
AU  - Udeh-Momoh,C
DO  - 10.1016/j.arr.2020.101171
EP  - 11
PY  - 2020///
SN  - 1568-1637
SP  - 1
TI  - Cortisol hypersecretion and the risk of Alzheimer’s disease: A systematic review and meta-analysis
T2  - Ageing Research Reviews
UR  - http://dx.doi.org/10.1016/j.arr.2020.101171
UR  - https://www.sciencedirect.com/science/article/pii/S1568163720303068?via%3Dihub
UR  - http://hdl.handle.net/10044/1/82967
VL  - 64
ER  -
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