Imperial College London
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DrLukeMoore

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

l.moore Website CV

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hughes:2022:10.1136/ejhpharm-2020-002445,
author = {Hughes, S and Heard, K and Mughal, N and Moore, LSP},
doi = {10.1136/ejhpharm-2020-002445},
journal = {European Journal of Hospital Pharmacy},
pages = {280--283},
title = {Burden of enteral supplement interactions with common antimicrobial agents: a single-centre observational analysis},
url = {http://dx.doi.org/10.1136/ejhpharm-2020-002445},
volume = {29},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Oral antimicrobials, including ciprofloxacin, levofloxacin and doxycycline, are susceptible to binding with enteral therapies such as calcium and iron therapies. Administered together, the bioavailability of these antimicrobials is expected to be reduced. METHODS: A retrospective case series of patients receiving oral antimicrobials (ciprofloxacin, levofloxacin and doxycycline) was analysed at a single-centre NHS acute hospital (April 2016-September 2019). Patient demographics, including concurrent enteral therapies, were recorded using medical records. Clinically important interactions were defined as doses administered within 2 hours of antimicrobial therapy. RESULTS: A total of 4067 prescriptions for the study antimicrobials (ciprofloxacin, n=1905; levofloxacin, n=538; and doxycycline, n=1624) were prescribed for 3584 patients. 1918/3583 (53.5%) of the patients were female, and the median age was 67 years (range 0.5-105.0 years). 810/4067 (19.3%) prescriptions reviewed had an interacting enteral therapy (calcium or iron salt) administered within 2 hours of the study medication. CONCLUSION: The concomitant administration of enteral calcium and iron with oral antimicrobials is common within the acute care hospital setting. Approximately one in five patients has a clinically important interaction which may impair oral bioavailability and limit treatment efficacy. As antimicrobial stewardship teams strive for increased intravenous-to-oral de-escalation, it is important that optimum dosing administration is followed to optimise patient outcomes.
AU  - Hughes,S
AU  - Heard,K
AU  - Mughal,N
AU  - Moore,LSP
DO  - 10.1136/ejhpharm-2020-002445
EP  - 283
PY  - 2022///
SN  - 2047-9956
SP  - 280
TI  - Burden of enteral supplement interactions with common antimicrobial agents: a single-centre observational analysis
T2  - European Journal of Hospital Pharmacy
UR  - http://dx.doi.org/10.1136/ejhpharm-2020-002445
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33414257
UR  - https://ejhp.bmj.com/content/early/2021/01/07/ejhpharm-2020-002445
UR  - http://hdl.handle.net/10044/1/85789
VL  - 29
ER  -
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