Imperial College London
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DrLukeMoore

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

l.moore Website CV

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Denny:2021:10.1186/s12879-021-06159-8,
author = {Denny, S and Rawson, T and Hart, P and Satta, G and Pallett, S and Abdulaal, A and Hughes, S and Gilchrist, M and Mughal, N and Moore, L},
doi = {10.1186/s12879-021-06159-8},
journal = {BMC Infectious Diseases},
pages = {1--9},
title = {Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis},
url = {http://dx.doi.org/10.1186/s12879-021-06159-8},
volume = {21},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background – We investigated for change in blood stream infections (BSI) with Enterobacterales, coagulase negative staphylococci (CoNS), Streptococcus pneumoniae, and Staphylococcus aureus during the first UK wave of SARS-CoV-2 across five London hospitals.Methods – A retrospective multicentre ecological analysis was undertaken evaluating all blood cultures taken from adults from 01 April 2017 to 30 April 2020 across five acute hospitals in London. Linear trend analysis and ARIMA models allowing for seasonality were used to look for significant variation.Results –119,584 blood cultures were included. At the height of the UK SARS-CoV-2 first wave in April 2020, Enterobacterales bacteraemias were at an historic low across two London trusts (63/3814, 1.65%), whilst all CoNS BSI were at an historic high (173/3814, 4.25%). This differed significantly for both Enterobacterales (p=0.013), CoNS central line associated BSIs (CLABSI) (p<0.01) and CoNS non-CLABSI (p<0.01), when compared with prior periods, even allowing for seasonal variation. S. pneumoniae (p=0.631) and S. aureus (p=0.617) BSI did not vary significant throughout the study period. Conclusions – Significantly fewer than expected Enterobacterales BSI occurred during the UK peak of the COVID-19 pandemic; identifying potential causes, including potential unintended consequences of national self-isolation public health messaging, is essential. High rates of CoNS BSI, with evidence of increased CLABSI, but also likely contamination associated with increased use of personal protective equipment, may result in inappropriate antimicrobial use and indicates a clear area for intervention during further waves.
AU  - Denny,S
AU  - Rawson,T
AU  - Hart,P
AU  - Satta,G
AU  - Pallett,S
AU  - Abdulaal,A
AU  - Hughes,S
AU  - Gilchrist,M
AU  - Mughal,N
AU  - Moore,L
DO  - 10.1186/s12879-021-06159-8
EP  - 9
PY  - 2021///
SN  - 1471-2334
SP  - 1
TI  - Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis
T2  - BMC Infectious Diseases
UR  - http://dx.doi.org/10.1186/s12879-021-06159-8
UR  - https://www.imperial.ac.uk/people/l.moore
UR  - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06159-8
UR  - http://hdl.handle.net/10044/1/88625
VL  - 21
ER  -
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