Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Research Fellow







G45Emmanuel Kaye BuildingRoyal Brompton Campus





Laura Nolan completed her undergraduate BSc (Honours) degree at the University of Sydney in Australia before moving to the University of Technology Sydney where she completed her PhD in 2014. Her PhD focused on understanding the role of small signalling molecules in biofilm expansion of Pseudomonas aeruginosa. In 2014 she was awarded a Marie SkÅ‚odowska-Curie Fellowship to work at Imperial College London at the Centre for Molecular Bacteriology and Infection (MRC CMBI). Her research during this time was focused on the type VI secretion system (T6SS) of P. aeruginosa and on identifying novel naturally validated antibacterial targets for therapeutic development. In August 2019 she was awarded an Imperial College Research Fellowship to start her own research group at the National Heart and Lung Institute (NHLI) at Imperial College. Her team's research focuses on understanding how bacteria form complex communities called biofilms and how bacterial interactions shape population profile dynamics within these communities. The group currently has a major focus on bacterial biofilms and interactions that are relevant to the Cystic Fibrosis (CF) lung environment. In 2019 Laura was awarded a CF Trust Venture Innovation Award to support this research at NHLI.

Selected Publications

Journal Articles

Murphy RA, Pizzato J, Cuthbertson L, et al., 2024, Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification, Npj Antimicrobials and Resistance, Vol:2, ISSN:2731-8745

Turnbull L, Leigh R, Cavaliere R, et al., 2021, Device design modifications informed by in vitro testing of bacterial attachment reduce infection rates of cochlear implants in clinical practice, Microorganisms, Vol:9, ISSN:2076-2607

Nolan LM, Cain AK, Clamens T, et al., 2021, Identification of tse8 as a type VI secretion system toxin from pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells, Nature Microbiology, Vol:6, ISSN:2058-5276, Pages:1199-+

Mandal PK, Ballerin G, Nolan LM, et al., 2021, Bacteriophage infection of Escherichia coli leads to the formation of membrane vesicles via both explosive cell lysis and membrane blebbing, Microbiology, Vol:167, ISSN:1350-0872, Pages:1-9

Hynen AL, Lazenby JJ, Savva GM, et al., 2021, Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms, Microbiology, Vol:167, ISSN:1350-0872, Pages:1-12

Nolan LM, Turnbull L, Katrib M, et al., 2020, Pseudomonas aeruginosa is capable of natural transformation in biofilms, Microbiology, Vol:10, ISSN:1350-0872, Pages:995-1003

Nolan LM, McCaughey LC, Merjane J, et al., 2020, ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides, Microbiology, Vol:166, ISSN:1350-0872, Pages:669-678

Allsopp LP, Bernal P, Nolan LM, et al., 2020, Causalities of war: the connection between type VI secretion system and microbiota, Cellular Microbiology, Vol:22, ISSN:1462-5814, Pages:1-9

Wood TE, Howard SA, Forster A, et al., 2019, The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology, Cell Reports, Vol:29, ISSN:2211-1247, Pages:187-201.e7

Cain AK, Nolan LM, Sullivan GJ, et al., 2019, Complete genome sequence of pseudomonas aeruginosa reference strain PAK, Microbiology Resource Announcements, Vol:8, ISSN:2576-098X

Lorenz A, Preusse M, Bruchmann S, et al., 2019, Importance of flagella in acute and chronic Pseudomonas aeruginosa infections, Environmental Microbiology, Vol:21, ISSN:1462-2912, Pages:883-897

Nolan LM, Whitchurch CB, Barquist L, et al., 2018, A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in <i>Pseudomonas aeruginosa</i>, Microbial Genomics, Vol:4, ISSN:2057-5858

Allsopp LP, Wood TE, Howard SA, et al., 2017, RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences of the United States of America, Vol:114, ISSN:1091-6490, Pages:7707-7712

Nolan LM, Cavaliere R, Turnbull L, et al., 2015, Extracellular ATP inhibits twitching motility-mediated biofilm expansion by Pseudomonas aeruginosa, Bmc Microbiology, Vol:15

Mackie A, Keseler IM, Nolan L, et al., 2013, Dead End Metabolites - Defining the Known Unknowns of the E. coli Metabolic Network, Plos One, Vol:8, Pages:e75210-e75210

Gloag ES, Turnbull L, Huang A, et al., 2013, Self-organization of bacterial biofilms is facilitated by extracellular DNA, Proceedings of the National Academy of Sciences of the United States of America, Vol:110, ISSN:0027-8424, Pages:11541-11546

Nolan LM, Beatson SA, Croft L, et al., 2012, Extragenic suppressor mutations that restore twitching motility to <scp><i>fimL</i></scp> mutants of <i><scp>P</scp>seudomonas aeruginosa</i> are associated with elevated intracellular cyclic <scp>AMP</scp> levels, Microbiologyopen, Vol:1, ISSN:2045-8827, Pages:490-501

Coleman NV, Yau S, Wilson NL, et al., 2011, Untangling the multiple monooxygenases of <i>Mycobacterium chubuense</i> strain NBB4, a versatile hydrocarbon degrader, Environmental Microbiology Reports, Vol:3, ISSN:1758-2229, Pages:297-307

Keseler IM, Bonavides-Martinez C, Collado-Vides J, et al., 2009, EcoCyc: A comprehensive view of Escherichia coli biology, Nucleic Acids Research, Vol:37, ISSN:0305-1048, Pages:D464-D470


Nolan LM, Allsopp LP, 2022, Antimicrobial Weapons of Pseudomonas aeruginosa, Pseudomonas aeruginosa, Editor(s): Filloux, Ramos, SPRINGER INTERNATIONAL PUBLISHING AG, Pages:223-256, ISBN:978-3-031-08490-4

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