My research interests are the development of mathematical models of malaria and analysis of epidemiological data in collaboration with policy-makers to better understand malaria burden, the impact of public health interventions and to inform malaria control policy.
I currently hold a Royal Society Dorothy Hodgkin Fellowship and my research focuses on assessing use of different types of antimalarial treatments in Africa and their impact on community-wide transmission, prophylaxis, and the international spread of drug resistant Plasmodium falciparum malaria. I also have have a particular interest in the contribution of low density malaria infections to sustaining transmission.
The effect of a given malaria control intervention can often vary between different epidemiological settings, and I have applied models to specific endemic settings in Africa in collaboration with field-based staff and policy makers in order to understand where and under what conditions different strategies can be most appropriate.
et al., 2018, Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether-lumefantrine and artesunate-amodiaquine in Africa, Bmj Global Health, Vol:3, ISSN:2059-7908
et al., 2017, Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling, Nature Communications, Vol:8, ISSN:2041-1723
Okell L, Griffin JT, Roper C, 2017, Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa, Scientific Reports, Vol:7, ISSN:2045-2322
et al., 2017, Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study, The Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:E680-E687
Okell LC, Churcher TS, 2016, Generating the evidence base for malaria elimination: the situation in Haiti, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:e16-e17
Slater HC, Okell LC, Ghani AC, 2016, Mathematical Modelling to Guide Drug Development for Malaria Elimination, Trends in Parasitology, Vol:33, ISSN:1471-5007, Pages:175-184
et al., 2016, Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa., Malaria Journal, Vol:15, ISSN:1475-2875
et al., 2015, Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies, Nature, Vol:528, ISSN:0028-0836, Pages:S86-S93
et al., 2014, Asymptomatic malaria infections: detectability, transmissibility and public health relevance, Nature Reviews Microbiology, Vol:12, ISSN:1740-1526, Pages:833-840
et al., 2014, Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2012, Factors determining the occurrence of submicroscopic malaria infections and their relevance for control, Nature Communications, Vol:3, ISSN:2041-1723
et al., 2011, The Potential Contribution of Mass Treatment to the Control of Plasmodium falciparum Malaria, PLOS One, Vol:6, ISSN:1932-6203
et al., 2010, Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies., Plos Med, Vol:7, ISSN:1549-1676, Pages:1-27
et al., 2010, Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs, Malaria Journal, Vol:9, ISSN:1475-2875
et al., 2009, Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis, J Infect Dis, Vol:200, ISSN:1537-6613, Pages:1509-1517
et al., 2008, Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity, Plos Med, Vol:5, ISSN:1549-1676, Pages:e226-e226