Imperial College London
Alternate

DrLucyOkell

Faculty of Medicine, School of Public Health

Senior Lecturer & Royal Society Dorothy Hodgkin Fellow
 
 
 
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Contact

 

l.okell Website

 
 
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Location

 

410School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Okell:2022:10.1101/2022.01.26.22269679,
author = {Okell, LC and Kwambai, TK and Dhabangi, A and Khairallah, C and Nkosi-Gondwe, T and Opoka, R and Mousa, A and Kühl, M-J and Lucas, TCD and Idro, R and Weiss, DJ and Cairns, M and ter, Kuile FO and Phiri, K and Robberstad, B and Mori, AT},
doi = {10.1101/2022.01.26.22269679},
title = {Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa},
url = {http://dx.doi.org/10.1101/2022.01.26.22269679},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) reduces this risk. We developed a mathematical model describing the daily incidence of uncomplicated and severe malaria requiring readmission among 0-5 year-old children after hospitalised SMA. We fitted the model to a multicentre clinical PDMC trial using Bayesian methods. We then modelled the potential impact of PDMC across malaria-endemic African countries. In the 19 highest-burden countries, we estimate that only 2-5 children need to be given PDMC to prevent one hospitalised malaria episode, and less than 100 to prevent one death. If all hospitalised SMA cases access PDMC, 37,000 (range 16,000-84,000) malaria-associated readmissions could be prevented annually, depending on access to hospital care. We estimate that recurrent SMA post-discharge constitutes 18-29% of all SMA episodes in higher transmission settings.</jats:p>
AU  - Okell,LC
AU  - Kwambai,TK
AU  - Dhabangi,A
AU  - Khairallah,C
AU  - Nkosi-Gondwe,T
AU  - Opoka,R
AU  - Mousa,A
AU  - Kühl,M-J
AU  - Lucas,TCD
AU  - Idro,R
AU  - Weiss,DJ
AU  - Cairns,M
AU  - ter,Kuile FO
AU  - Phiri,K
AU  - Robberstad,B
AU  - Mori,AT
DO  - 10.1101/2022.01.26.22269679
PY  - 2022///
TI  - Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa
UR  - http://dx.doi.org/10.1101/2022.01.26.22269679
ER  -
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