Imperial College London


Faculty of MedicineDepartment of Brain Sciences

Research Fellow



+44 (0)20 7594 7028l.paterson




Burlington DanesHammersmith Campus





I am a Research Fellow in the Division of PsychiatryNeuropsychopharmacology Unit. Our research is focused on investigating the mechanisms and neuropharmacology of addiction using neuroimaging, experimental medicine and clinical trials, with the aim of developing novel therapies for the treatment of substance dependence.

My work seeks to identify novel brain indices of addiction and relapse derived from multi-modal neuroimaging methods, to further understand the brain circuitry of reward, emotion and inhibitory control and to explore their modulation by pharmacological interventions with therapeutic potential.

Current studies include the NCORE study; an fMRI study of the effect of NK1 receptor antagonism on reward and emotional processing in opiate dependence, the IMBAC study investigating the effects of baclofen- a GABA-B agonist- on these same brain pathways in alcoholism, and the ICCAM platform study, a multi-centre fMRI study of the neuropharmacology of addiction, which investigated the effects of opioid, dopamine and NK1 receptor antagonism on brain pathways involved in reward, inhibitory control and stress/emotional processing. 

I am an Associate Member of the ITMAT Data Sciences Group at Imperial College, collaborating on a BRC funded project to identify predictors of relapse using multivariate and machine learning classification methods.

I also have an interest in sleep, and have previously been involved in studies of sleep architecture in healthy subjects, insomnia, depression and deep brain stimulation.

None of our research can be done without the support of our research volunteers. If you are interested in our research and would like to be involved in a study, either as a healthy volunteer, or as someone who suffers with drug and/or alcohol problems, please get in touch at



Mozgunov P, Cro S, Lingford-Hughes A, et al., 2022, A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial, Pharmaceutical Statistics: the Journal of Applied Statistics in the Pharmaceutical Industry, Vol:21, ISSN:1539-1604, Pages:476-495

Nutt D, Hayes A, Fonville L, et al., 2021, Alcohol and the Brain, Nutrients, Vol:13

Fonville L, Paterson L, Herlinger K, et al., 2021, Functional evaluation of NK1 antagonism on cue reactivity in opiate dependence; an fMRI study, Drug and Alcohol Dependence, Vol:221, ISSN:0376-8716, Pages:1-7

Orban C, McGonigle J, Flechais RSA, et al., 2020, Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: A cross-sectional study, Addiction Biology, Vol:26, ISSN:1355-6215

Hayes A, Herlinger K, Paterson L, et al., 2020, The neurobiology of substance use and addiction: evidence from neuroimaging and relevance to treatment, Bjpsych Advances, ISSN:2056-4678, Pages:1-12

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