Publications
68 results found
Taylor EM, Murphy A, Ersche KD, et al., 2015, Neuropsychological, self-report and neurocognitive measures of impulsivity in substance-dependent individuals compared to controls, ECNP Workshop for Junior Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S85-S86, ISSN: 0924-977X
Brust P, Deuther-Conrad W, Donat CK, et al., 2014, Preclinical aspects of nicotinic acetylcholine receptor imaging., PET and SPECT of Neurobiological Systems, Editors: Dierckx, Otte, de Vries, van Waarde, Luiten, Publisher: Springer-Verlag Berlin Heidelberg
Paterson LM, Kornum BR, Nutt DJ, et al., 2013, 5-HT radioligands for human brain imaging with PET and SPECT, MEDICINAL RESEARCH REVIEWS, Vol: 33, Pages: 54-111, ISSN: 0198-6325
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- Citations: 108
Durant CF, Wilson SJ, Lightman S, et al., 2012, Sleep and the HPA axis; the effect on sleep of two doses of hydrocortisone administered as a bolus during the day in healthy volunteers, 21st Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL, Pages: 24-24, ISSN: 0962-1105
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- Citations: 1
Paterson LM, Nutt DJ, Wilson SJ, 2011, Sleep and its disorders in translational medicine, J.Psychopharmacol., Vol: 25, Pages: 1226-1234
The study of sleep is a useful approach to studying the brain in psychiatric disorders and in investigating the effects of psychotropic drugs. Sleep physiology lends itself well to pharmacological and physiological manipulation, as it has the advantage of a functional output, the electroencephalograph, which is common to all mammals, and can be measured in freely moving (or naturally sleeping) animals under controlled laboratory conditions or in a naturalistic home environment. The complexity of sleep architecture varies between species but all share features which are comparable. In addition, sleep architecture is sensitive to changes in brain neurotransmitters such as serotonin, so cross-species sleep measurement can be combined with pharmacological manipulation to investigate the receptor mechanisms controlling sleep-wake regulation and sleep architecture in response to known and novel agents. Translational approaches such as these have improved our understanding of sleep circuitry and facilitated the development of new treatments for sleep disorders, particularly insomnia. This review provides examples of how research findings within the sleep field have been translated between animal models, healthy volunteers and patient populations with particular focus on the serotonergic system
Wilson SJ, Paterson LM, Durant CF, et al., 2011, ACUTE EFFECTS OF HIGH DOSE HYDROCORTISONE ON SLEEP IN PATIENTS WITH TREATMENT RESISTANT DEPRESSION: A DOUBLE BLIND PLACEBO CONTROLLED STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A23-A23, ISSN: 0269-8811
Tyacke RJ, Durant CF, Paterson LM, et al., 2011, EFFECTS OF ACUTE INHALATION OF VAPORIZED CANNABIS OR PLACEBO ON CARDIOVASCULAR AND SACCADIC EYE MOVEMENT MEASURES: A PILOT STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A37-A37, ISSN: 0269-8811
Durant CF, Wilson SJ, Lightman S, et al., 2011, DOSE RELATED SLEEP CHANGES IN HEALTHY VOLUNTEERS AFTER TWO DOSES OF HYDROCORTISONE: A DOUBLE BLIND PLACEBO CONTROLLED STUDY, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A56-A56, ISSN: 0269-8811
Paterson LM, Tyacke RJ, Nutt DJ, et al., 2010, Measuring endogenous 5-HT release by emission tomography: promises and pitfalls, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 30, Pages: 1682-1706, ISSN: 0271-678X
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- Citations: 108
Durant CF, Malizia AL, Paterson LM, et al., 2010, DEEP BRAIN STIMULATION IN THE SUBGENUAL CINGULATE ALTERS REM SLEEP IN PATIENTS WITH TREATMENT RESISTANT DEPRESSION, Summer Meeting of the British-Association-for-Psychopharmacology, Publisher: SAGE PUBLICATIONS LTD, Pages: A54-A54, ISSN: 0269-8811
Durant C, Malizia AL, Paterson L, et al., 2010, Acute deep brain stimulation in the subgenual cingulate alters REM sleep in patients with treatment resistant depression, 23rd Congress Meeting of European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S343-S343, ISSN: 0924-977X
Paterson LM, Nutt DJ, Knudsen GM, 2010, A critical review of studies measuring endogenous 5-HT release by emission tomography, 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: S107-S107, ISSN: 1053-8119
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- Citations: 1
Durant C, Malizia AL, Paterson L, et al., 2010, Acute deep brain stimulation in the subgenual cingulate alters REM sleep in patients with treatment resistant depression, 23rd Congress Meeting of European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S343-S343, ISSN: 0924-977X
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- Citations: 1
Paterson L, Wilson SJ, Nutt DJ, 2009, NAtional Patient Sleep Assessment Questionnaire III (Napsaq-III) in depression; a survey for psychiatrists, 22nd Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S388-S388, ISSN: 0924-977X
Paterson LM, Nutt DJ, Durant C, et al., 2009, Efficacy of trazodone in primary insomnia; a double-blind randomised placebo controlled polysomnographic study, 22nd Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S385-S386, ISSN: 0924-977X
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- Citations: 2
Paterson LM, Nutt DJ, Ivarsson M, et al., 2009, Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers, J.Psychopharmacol., Vol: 23, Pages: 487-494
Caffeine is the world's most popular stimulant and is known to disrupt sleep. Administration of caffeine can therefore be used in healthy volunteers to mimic the effects of insomnia and thus to test the hypnotic effects of medication. This study assessed the effects of caffeine on sleep architecture and electroencephalography (EEG) spectrum alone and in combination with two different sleep-promoting medications. Home polysomnography was performed in 12 healthy male volunteers in a double-blind study whereby subjects received placebo, caffeine (150 mg), caffeine plus zolpidem (10 mg) and caffeine plus trazodone (100 mg) at bedtime in a randomised crossover design. In addition to delaying sleep onset, caffeine decreased total sleep time (TST), sleep efficiency (SE) and stage 2 sleep without significantly altering wake after sleep onset or the number of awakenings. Zolpidem attenuated the caffeine-induced decrease in SE and increased spindle density in the caffeine plus zolpidem combination compared with placebo. Trazodone attenuated the decrease in SE and TST, and it also increased stage 3 sleep, decreased the number of awakenings and decreased the spindle density. No significant changes in rapid eye movement (REM) sleep were observed, neither was any significant alteration in slow wave activity nor other EEG spectral measures, although the direction of change was similar to that previously reported for caffeine and appeared to 'normalise' after trazodone. These data suggest that caffeine mimics some, but not all of the sleep disruption seen in insomnia and that its disruptive effects are differentially attenuated by the actions of sleep-promoting compounds with distinct mechanisms of action
Paterson LM, Wilson SJ, Nutt DJ, et al., 2009, Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption, J.Psychopharmacol., Vol: 23, Pages: 475-486
Caffeine is known to disrupt sleep and its administration to human subjects has been used to model sleep disruption. We previously showed that its effects on sleep onset latency are comparable between rats and humans. This study evaluated the potential use of caffeine as a model of sleep disruption in the rat, by assessing its effects on sleep architecture and electroencephalogram (EEG) frequency spectrum, and using sleep-promoting drugs to reverse these effects. Rats were implanted with radiotelemetry devices for body temperature, EEG, electromyogram and locomotor activity. Following recovery, animals were dosed with caffeine (10 mg/kg) alone or in combination with zolpidem (10 mg/kg) or trazodone (20 mg/kg). Sleep was scored for the subsequent 12 h using automated analysis software. Caffeine dose-dependently disrupted sleep: it increased WAKE time, decreased NREM (non-REM) sleep time and NREM bout duration (but not bout number), and decreased delta activity in NREM sleep. It also dose-dependently increased locomotor activity and body temperature. When given alone, zolpidem suppressed REM whilst trazodone increased NREM sleep time at the expense of WAKE, increased NREM bout duration, increased delta activity in NREM sleep and reduced body temperature. In combination, zolpidem attenuated caffeine's effects on WAKE, whilst trazodone attenuated its effects on NREM sleep, NREM bout duration, delta activity, body temperature and locomotor activity. Caffeine administration produced many of the signs of insomnia that were improved by two of its most successful current treatments. This model may therefore be useful in the study of new drugs for the treatment of sleep disturbance
Durant C, Wilson S, Paterson L, et al., 2009, Sleep changes during deep brain stimulation for treatment resistant depression: preliminary findings from a case study, European-College-of-Neuropsychopharmacology Workshop on Neuropsychopharmacology for Young Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S67-S68, ISSN: 0924-977X
Paterson LM, Nutt DJ, Wilson SJ, 2009, NAPSAQ-1: National Patient Sleep Assessment Questionnaire in depression, INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, Vol: 13, Pages: 48-58, ISSN: 1365-1501
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- Citations: 10
Durant CF, Wilson SJ, Paterson LM, et al., 2008, Sleep changes associated with mood improvement during acute deep brain stimulation of two different brain targets for treatment resistant depression, 19th Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 259-260, ISSN: 0962-1105
Paterson LM, Nutt DJ, Wilson SJ, 2008, NAPSAQ II; national patient sleep assessment questionnaire in depression; a survey for general practitioners, 19th Congress of the European-Sleep-Research-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 260-260, ISSN: 0962-1105
Nutt D, Wilson S, Paterson L, 2008, Sleep disorders as core symptoms of depression, Dialogues in Clinical Neuroscience, Vol: 10, Pages: 329-336, ISSN: 1294-8322
Links between sleep and depression are strong. About three quarters of depressed patients have insomnia symptoms, and hypersomnia is present in about 40% of young depressed adults and 10% of older patients, with a preponderance in females. The symptoms cause huge distress, have a major impact on quality of life, and are a strong risk factor for suicide. As well as the subjective experience of sleep symptoms, there are well-documented changes in objective sleep architecture in depression. Mechanisms of sleep regulation and how they might be disturbed in depression are discussed. The sleep symptoms are often unresolved by treatment, and confer a greater risk of relapse and recurrence. Epidemiological studies have pointed out that insomnia in nondepressed subjects is a risk factor for later development of depression. There is therefore a need for more successful management of sleep disturbance in depression, in order to improve quality of life in these patients and reduce an important factor in depressive relapse and recurrence
Paterson LM, Nutt DJ, Wilson SJ, 2008, A national patient sleep assessment questionnaire in depression (NAPSAQ II); a survey for general practitioners, 21st Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S342-S342, ISSN: 0924-977X
Paterson LM, Dinotaro KD, Nutt DJ, et al., 2007, Sleep disturbance in depression: results from a UK survey, 20th Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S320-S320, ISSN: 0924-977X
Paterson LM, Wilson SJ, Nutt DJ, et al., 2007, A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers, Psychopharmacology (Berl), Vol: 191, Pages: 943-950
RATIONALE: Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate animal models to assess likely outcome in the clinic. OBJECTIVES: The purpose of this study was to develop a translational, caffeine-induced model of insomnia in rats and healthy volunteers. We used sleep onset latency (SOL) as a comparable sleep measure between the two species. The model was validated by two effective sleep-promoting agents with different pharmacology, zolpidem and trazodone, which have GABA-ergic and serotonergic mechanisms, respectively. MATERIALS AND METHODS: In rats, radiotelemetry transmitters with electroencephalogram and electromyogram electrodes were implanted for sleep recording. Animals were administered with caffeine alone (10 mg/kg) or in combination with zolpidem (10 mg/kg) or trazodone (20 mg/kg), or vehicle, in crossover experiments. Home polysomnography was performed in 12 healthy male volunteers in a randomised, placebo-controlled, 4-week crossover study. Subjects received placebo, caffeine (150 mg) or caffeine in combination with zolpidem (10 mg) or trazodone (100 mg). Subjective sleep effects in volunteers were assessed using the Leeds Sleep Evaluation Questionnaire. RESULTS: Caffeine caused a significant prolongation in objective SOL in rats and humans. This effect was sensitive to zolpidem and trazodone, both of which attenuated the caffeine-induced increase in SOL. Furthermore, both hypnotics restored the disruption in subjective measures of sleep onset caused by caffeine in volunteers. CONCLUSIONS: This model therefore provides a promising paradigm in which we can study novel treatments for sleep disorders and an opportunity for direct comparison of results between rodents and humans
Paterson LM, Tyacke RJ, Robinson ESJ, et al., 2007, In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I<sub>2</sub> binding in relation to MAO:: Evidence for two distinct I<sub>2</sub> binding sites, NEUROPHARMACOLOGY, Vol: 52, Pages: 395-404, ISSN: 0028-3908
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- Citations: 12
Paterson L, Ivarsson M, Hutson P, et al., 2006, Effects on sleep of caffeine and its combination with trazodone or zolpidem in healthy volunteers, 19th Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S551-S551, ISSN: 0924-977X
Paterson L, Ivarsson M, Hutson P, et al., 2006, Validation of a translational model of insomnia in rats and human volunteers, 19th Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S550-S550, ISSN: 0924-977X
Paterson LM, Wilson SJ, Nutt DJ, et al., 2006, Validation of a translational model of insomnia in rats and human volunteers, 18th Congress of the European-Sleep-Research-Society, Publisher: BLACKWELL PUBLISHING, Pages: 38-38, ISSN: 0962-1105
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- Citations: 1
Ivarsson M, Paterson LM, Hutson PH, 2005, Antidepressants and REM sleep in Wistar-Kyoto and Sprague-Dawley rats, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 522, Pages: 63-71, ISSN: 0014-2999
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- Citations: 49
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