Imperial College London
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DrLouisePaterson

Faculty of Medicine, Department of Brain Sciences

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7028l.paterson

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nestor:2019:10.1111/ejn.14262,
author = {Nestor, LJ and Paterson, LM and Murphy, A and McGonigle, J and Orban, C and Reed, L and Taylor, E and Flechais, R and Smith, D and Bullmore, ET and Ersche, KD and Suckling, J and Elliott, R and Deakin, B and Rabiner, I and Lingford, Hughes A and Sahakian, BJ and Robbins, TW and Nutt, DJ},
doi = {10.1111/ejn.14262},
journal = {European Journal of Neuroscience},
pages = {2311--2321},
title = {Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and poly-substance dependent individuals},
url = {http://dx.doi.org/10.1111/ejn.14262},
volume = {50},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Identifying key neural substrates in addiction disorders for targeted drug development remains a major challenge for clinical neuroscience. One emerging target is the opioid system, where substancedependent populations demonstrate prefrontal opioid dysregulation that predicts impulsivity and relapse. This may suggest that disturbances to the prefrontal opioid system could confer a risk for relapse in addiction due to weakened “topdown” control over impulsive behaviour. Naltrexone is currently licensed for alcohol dependence and is also used clinically for impulse control disorders. Using a go/nogo (GNG) task we examined the effects of acute naltrexone on the neural correlates of successful motor impulse control in abstinent alcoholics (AUD), abstinent poly substancedependent (polySUD) individuals, and controls during a randomized double blind placebo controlled fMRI study. In the absence of any differences on GNG task performance, the AUD group showed a significantly greater BOLD response compared to the control group in lateral and medial prefrontal regions during both placebo and naltrexone treatments; effects that were positively correlated with alcohol abstinence. There was also a dissociation in the positive modulating effects of naltrexone in the orbitofrontal cortex (OFC) and anterior insula cortex (AIC) of the AUD and polySUD groups respectively. Selfreported trait impulsivity in the polySUD group also predicted the effect of naltrexone in the AIC. These results suggest that acute naltrexone differentially amplifies neural responses within two distinct regions of a salience network during successful motor impulse control in abstinent AUD and polySUD groups, which are predicted by trait impulsivity in the polySUD group.
AU  - Nestor,LJ
AU  - Paterson,LM
AU  - Murphy,A
AU  - McGonigle,J
AU  - Orban,C
AU  - Reed,L
AU  - Taylor,E
AU  - Flechais,R
AU  - Smith,D
AU  - Bullmore,ET
AU  - Ersche,KD
AU  - Suckling,J
AU  - Elliott,R
AU  - Deakin,B
AU  - Rabiner,I
AU  - Lingford,Hughes A
AU  - Sahakian,BJ
AU  - Robbins,TW
AU  - Nutt,DJ
DO  - 10.1111/ejn.14262
EP  - 2321
PY  - 2019///
SN  - 0953-816X
SP  - 2311
TI  - Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and poly-substance dependent individuals
T2  - European Journal of Neuroscience
UR  - http://dx.doi.org/10.1111/ejn.14262
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/ejn.14262
UR  - http://hdl.handle.net/10044/1/64321
VL  - 50
ER  -
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