Imperial College London
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DrLouisePaterson

Faculty of Medicine, Department of Brain Sciences

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7028l.paterson

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nestor:2016:10.1111/adb.12444,
author = {Nestor, LJ and Murphy, A and McGonigle, J and Orban, C and Reed, L and Taylor, E and Flechais, R and Paterson, LM and Smith, D and Bullmore, ET and Ersche, KD and Suckling, J and Tait, R and Elliott, R and Deakin, B and Rabiner, I and Lingford-Hughes, A and Nutt, DJ and Sahakian, B and Robbins, TW and ICCAM, Consortium},
doi = {10.1111/adb.12444},
journal = {Addiction Biology},
pages = {1576--1589},
title = {Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task},
url = {http://dx.doi.org/10.1111/adb.12444},
volume = {22},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is a concerted research effort to investigate brain mechanisms underlying addiction processes that may predicate the development of new compounds for treating addiction. One target is the brain's opioid system, because of its role in the reinforcing effects of substances of abuse. Substance-dependent populations have increased numbers of the mu opioid receptor (MOR) in fronto-striatal regions that predict drug relapse, and demonstrate disturbances in these regions during the processing of non-drug rewards. Naltrexone is currently licensed for alcohol and opiate dependence, and may remediate such disturbances through the blockade of MORs in fronto-striatal reward circuitry. Therefore, we examined the potential acute modulating effects of naltrexone on the anticipation of, and instrumental responding for, non-drug rewards in long-term abstinent alcoholics, alcoholic poly substance-dependent individuals and controls using a monetary incentive delay (MID) task during a randomized double blind placebo controlled functional MRI study. We report that the alcoholic poly substance-dependent group exhibited slower and less accurate instrumental responding compared to alcoholics and controls that was less evident after acute naltrexone treatment. However, naltrexone treatment was unable to remediate disturbances within fronto-striatal regions during reward anticipation and 'missed' rewards in either substance-dependent group. While we have not been able to identify the underlying neural mechanisms for improvement observed with naltrexone in the alcoholic poly-substance dependent group, we can confirm that both substance-dependent groups exhibit substantial neural deficits during an MID task, despite being in long-term abstinence.
AU  - Nestor,LJ
AU  - Murphy,A
AU  - McGonigle,J
AU  - Orban,C
AU  - Reed,L
AU  - Taylor,E
AU  - Flechais,R
AU  - Paterson,LM
AU  - Smith,D
AU  - Bullmore,ET
AU  - Ersche,KD
AU  - Suckling,J
AU  - Tait,R
AU  - Elliott,R
AU  - Deakin,B
AU  - Rabiner,I
AU  - Lingford-Hughes,A
AU  - Nutt,DJ
AU  - Sahakian,B
AU  - Robbins,TW
AU  - ICCAM,Consortium
DO  - 10.1111/adb.12444
EP  - 1589
PY  - 2016///
SN  - 1369-1600
SP  - 1576
TI  - Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task
T2  - Addiction Biology
UR  - http://dx.doi.org/10.1111/adb.12444
UR  - http://hdl.handle.net/10044/1/42591
VL  - 22
ER  -
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