Publications
355 results found
Rai R, Regan L, 2011, Recurrent Miscarriage and Thrombophilia, Disorders of thrombosis and haemostasis in Obstetrics, Editors: Cohen, O'Brien
Regan L, 2011, Early pregnancy failure after ART, Pregnancy following assisted reproductive technology, Editors: Jauniaux, Rizk
Saravelos SH, Regan L, 2011, The importance of preconception counselling and early pregnancy monitoring, Seminars in Reproductive Medicine, Editors: Stephenson, Bulun
Hiby SE, Apps R, Sharkey AM, et al., 2010, Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2, JOURNAL OF CLINICAL INVESTIGATION, Vol: 120, Pages: 4102-4110, ISSN: 0021-9738
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- Citations: 356
Zaher S, Gedroyc W, Lyons D, et al., 2010, A novel method to aid in the visualisation and treatment of uterine fibroids with MRgFUS in patients with abdominal scars, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 76, Pages: 269-273, ISSN: 0720-048X
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- Citations: 14
Derpapas A, Ahmed S, Regan L, et al., 2010, RACIAL DIFFERENCES IN FEMALE URETHRAL SPHINCTER MORPHOLOGY, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 21, Pages: S106-S107, ISSN: 0937-3462
Baud D, Regan L, Greub G, 2010, Comparison of five commercial serological tests for the detection of anti-Chlamydia trachomatis antibodies, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol: 29, Pages: 669-675, ISSN: 0934-9723
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- Citations: 26
Regan L, 2010, Your Pregnancy Week by Week, Publisher: Dorling Kindersley, ISBN: 9781405348799
Teklenburg G, Salker M, Molokhia M, et al., 2010, Natural selection of human embryos: decidualizing endometrial stromal Cells serve as sensors of embryo quality upon implantation, PLoS One, Vol: 5, Pages: 1-6, ISSN: 1932-6203
BackgroundPregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the high prevalence of chromosomally abnormal preimplantation embryos. Moreover, the transient period of endometrial receptivity in humans uniquely coincides with differentiation of endometrial stromal cells (ESCs) into highly specialized decidual cells, which in the absence of pregnancy invariably triggers menstruation. The role of cyclic decidualization of the endometrium in the implantation process and the nature of the decidual cytokines and growth factors that mediate the crosstalk with the embryo are unknown.Methodology/Principal FindingsWe employed a human co-culture model, consisting of decidualizing ESCs and single hatched blastocysts, to identify the soluble factors involved in implantation. Over the 3-day co-culture period, approximately 75% of embryos arrested whereas the remainder showed normal development. The levels of 14 implantation factors secreted by the stromal cells were determined by multiplex immunoassay. Surprisingly, the presence of a developing embryo had no significant effect on decidual secretions, apart from a modest reduction in IL-5 levels. In contrast, arresting embryos triggered a strong response, characterized by selective inhibition of IL-1β, -6, -10, -17, -18, eotaxin, and HB-EGF secretion. Co-cultures were repeated with undifferentiated ESCs but none of the secreted cytokines were affected by the presence of a developing or arresting embryo.ConclusionsHuman ESCs become biosensors of embryo quality upon differentiation into decidual cells. In view of the high incidence of gross chromosomal errors in human preimplantation embryos, cyclic decidualization followed by menstrual shedding may represent a mechanism of natural embryo selection that limits maternal investment in deve
Salker M, Teklenburg G, Molokhia M, et al., 2010, Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss, PLOS One, Vol: 5, ISSN: 1932-6203
Background: Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either torepeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesisthat abnormal cyclic differentiation of endometrial stromal cells (ESCs) into specialized decidual cells predisposes to RPL,based on the observation that this process may not only be indispensable for placenta formation in pregnancy but also forembryo recognition and selection at time of implantation.Methodology/Principal Findings: Analysis of mid-secretory endometrial biopsies demonstrated that RPL is associated withdecreased expression of the decidual marker prolactin (PRL) but increased levels of prokineticin-1 (PROK1), a cytokine thatpromotes implantation. These in vivo findings were entirely recapitulated when ESCs were purified from patients with andwithout a history of RPL and decidualized in culture. In addition to attenuated PRL production and prolonged and enhancedPROK1 expression, RPL was further associated with a complete dysregulation of both markers upon treatment of ESCcultures with human chorionic gonadotropin, a glycoprotein hormone abundantly expressed by the implanting embryo. Wepostulated that impaired embryo recognition and selection would clinically be associated with increased fecundity, definedby short time-to-pregnancy (TTP) intervals. Woman-based analysis of the mean and mode TTP in a cohort of 560 RPLpatients showed that 40% can be considered ‘‘superfertile’’, defined by a mean TTP of 3 months or less.Conclusions: Impaired cyclic decidualization of the endometrium facilitates implantation yet predisposes to subsequentpregnancy failure by disabling natural embryo selection and by disrupting the maternal responses to embryonic signals.These findings suggest a novel pathological pathway that unifies maternal and embryonic causes of RPL.
Zaher S, Lyons D, Regan L, 2010, Uncomplicated term vaginal delivery following magnetic resonance-guided focused ultrasound surgery for uterine fibroids., Biomedical Imaging and Intervention Journal: a multidisciplinary open access online journal, Vol: 6, Pages: 1-4, ISSN: 1823-5530
A 35 year-old para 1+0 underwent MRgFUS per study protocol for multiple uterine fibroids, the largest of which measured 5 cm. She conceived 10 months following the procedure. The patient was induced at 41+6 weeks and underwent a normal vaginal delivery.
Regan L, Simpson JL, 2010, I'm Pregnant! a week-by-week guide from conception to birth, Publisher: Dk Pub, ISBN: 9780756658700
Miller A, Rai R, Regan L, 2010, Plasminogen Activator Inhibitor-1, Polycystic Ovarian Morphology and Recurrent Miscarriage., 57th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 339A-340A, ISSN: 1933-7191
Wimalasundera RC, Wijetunge S, Thom SM, et al., 2010, Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia, JOURNAL OF HYPERTENSION, Vol: 28, Pages: 568-574, ISSN: 0263-6352
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- Citations: 3
Regan L, Backos M, Farquharson R, 2010, Recurrent miscarriage, High Risk Pregnancy: Management Options, Editors: James, Steer, Weiner, Gonik, Philadelphia, Pennsylvania, Publisher: Elsevier Saunders
Hameed A, Regan L, 2010, Acquired thrombophilia and recurrent early pregnancy loss, Early Pregnancy, Editors: Farquharson, Stephenson, Publisher: Cambridge University Press
Regan L, 2010, Votre grossesse au jour le jour, Publisher: Editions Hurtubise HMH ltee, Montreal, ISBN: 9782896473014
Derpapas A, Ahmed S, Regan L, et al., 2010, RACIAL DIFFERENCES IN FEMALE URETHRAL SPHINCTER MORPHOLOGY, Joint Meeting of the International-Continence-Society/International-Urogynecological-Association, Publisher: WILEY-BLACKWELL, Pages: 910-911, ISSN: 0733-2467
Devaseelan P, Fogarty PP, Regan L, 2010, Human chorionic gonadotrophin for threatened miscarriage, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X
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- Citations: 29
Bagratee JS, Regan L, Khullar V, et al., 2009, Reference intervals of gestational sac, yolk sac and embryo volumes using three-dimensional ultrasound, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 34, Pages: 503-509, ISSN: 0960-7692
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- Citations: 23
Taran FA, Tempany CMC, Regan L, et al., 2009, Magnetic resonance-guided focused ultrasound (MRgFUS) compared with abdominal hysterectomy for treatment of uterine leiomyomas, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 34, Pages: 572-578, ISSN: 0960-7692
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- Citations: 68
Abu-Amero S, Moore G, Regan L, et al., 2009, The Baby Bio Bank of London, British Human Genetics Conference, Publisher: B M J PUBLISHING GROUP, Pages: S113-S113, ISSN: 0022-2593
Baud D, Peter O, Langel C, et al., 2009, Seroprevalence of <i>Coxiella burnetii</i> and <i>Brucella abortus</i> among pregnant women, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 15, Pages: 499-501, ISSN: 1198-743X
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- Citations: 27
Zaher S, Gedroyc WM, Regan L, 2009, Patient suitability for magnetic resonance guided focused ultrasound surgery of uterine fibroids, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 143, Pages: 98-102, ISSN: 0301-2115
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- Citations: 36
Lo W, Rai R, Aisha H, et al., 2009, The Effect of Body Mass Index on Pregnancy Outcome in Women with Recurrent Miscarriage., 56th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 357A-358A, ISSN: 1933-7191
Hameed A, Rai R, Lo W, et al., 2009, Reproductive Outcome in Women Age 40 Years or Older with a History of Recurrent Miscarriage-2 Year Follow up., 56th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 356A-356A, ISSN: 1933-7191
Disu SA, Zaher S, Hameed A, et al., 2009, Management of Fibroids in an Inner London Teaching Hospital - A Review of 2 Treatment Modalities: MRgFUS (Magnetic Resonance Guided Focused Ultrasound) Versus UAE (Uterine Artery Embolisation), 56th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 123A-123A, ISSN: 1933-7191
Al-Ghamdi A, Rai R, Hameed A, et al., 2009, Peripheral Blood Karyotyping amongst Couples with Recurrent Miscarriage-Universal or Selective Screening?, 56th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 185A-185A, ISSN: 1933-7191
Hameed A, Lo W, Disu S, et al., 2009, Pregnancy Outcome in Women with History of Higher Order (≥6) Recurrent Miscarriages., 56th Annual Meeting of the Society-for-Gynecologic-Investigation, Publisher: SAGE PUBLICATIONS INC, Pages: 355A-356A, ISSN: 1933-7191
Zowall H, Cairns JA, Brewer C, et al., 2008, Cost-Effectiveness of magnetic Resonance-Guided focused ultrasound surgery for treatment of uterine fibroids, Obstetrical and Gynecological Survey, Vol: 63, Pages: 427-428, ISSN: 0029-7828
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- Citations: 2
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