Imperial College London

ProfessorLesleyRegan

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Clinical Professor
 
 
 
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Contact

 

+44 (0)20 3312 1798l.regan

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

MWG022Mint WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

355 results found

Zowall H, Cairns JA, Brewer C, Lamping DL, Gedroyc WM, Regan Let al., 2008, Cost-effectiveness of magnetic resonance-guided focused ultrasound surgery for treatment of uterine fibroids, VALUE IN HEALTH, Vol: 11, Pages: A250-A250, ISSN: 1098-3015

Journal article

Collins J, Diedrich K, Franks S, Geraedts JPM, Jacobs PA, Karges B, Kennedy S, Marozzi A, Regan L, Baird DT, Crosignani PG, Devroey P, Diczfalusy E, Evers JLH, Fauser BCJM, Fraser L, Gianaroli L, Glasier A, Liebaers I, Ragni G, Sunde A, Tarlatzis B, Van Steirteghem Aet al., 2008, Genetic aspects of female reproduction, HUMAN REPRODUCTION UPDATE, Vol: 14, Pages: 293-307, ISSN: 1355-4786

Journal article

Zowall H, Cairns JA, Brewer C, Lamping DL, Gedroyc WMW, Regan Let al., 2008, Cost-effectiveness of magnetic resonance-guided focused ultrasound surgery for treatment of uterine fibroids, BJOG: an International Journal of Obstetrics and Gynaecology, Vol: 115, Pages: 653-662, ISSN: 1470-0328

Objective To estimate the cost-effectiveness of a treatment strategy for symptomatic uterine fibroids, which starts with Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) as compared with current practice comprising uterine artery embolisation, myomectomy and hysterectomy.Design Cost-utility analysis based on a Markov model.Setting National Health Service (NHS) Trusts in England and Wales.Population Women for whom surgical treatment for uterine fibroids is being considered.Methods The parameters of the Markov model of the treatment of uterine fibroids are drawn from a series of clinical studies of MRgFUS, and from the clinical effectiveness literature. Health-related quality of life is measured using the 6D. Costs are estimated from the perspective of the NHS. The impact of uncertainty is examined using deterministic and probabilistic sensitivity analysis.Main outcome measures Incremental cost-effectiveness measured by cost per quality-adjusted life-year (QALY) gained.Results The base-case results imply a cost saving and a small QALY gain per woman as a result of an MRgFUS treatment strategy. The cost per QALY gained is sensitive to cost of MRgFUS relative to other treatments, the age of the woman and the nonperfused volume relative to the total fibroids volume.Conclusions A treatment strategy for symptomatic uterine fibroids starting with MRgFUS is likely to be cost-effective.

Journal article

Hiby SE, Regan L, Lo W, Farrell L, Carrington M, Moffett Aet al., 2008, Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage, HUMAN REPRODUCTION, Vol: 23, Pages: 972-976, ISSN: 0268-1161

Journal article

Baud D, Regan L, Greub G, 2008, Emerging robe of <i>Chlamydia</i> and <i>Chlamydia</i>-like organisms in adverse pregnancy outcomes, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 21, Pages: 70-76, ISSN: 0951-7375

Journal article

Zaher S, Regan L, 2008, Magnetic resonance guided thermal ablation therapy for uterine fibroids, Recent Advances in Obstetrics and Gynaecology 24., Editors: Ledger, Dunlop, Pages: 167-176

Book chapter

Regan L, 2008, Genetic aspects of recurrent miscarriage, Proceedings of the ESHRE Capri workshop Group 2007. Genetic Aspects of Female Reproduction, Publisher: Human Reproduction Update: 2008, Pages: 293-307

Book chapter

Baud D, Thomas V, Arafa A, Regan L, Greub Get al., 2007, Waddlia chondrophila, a potential agent of human fetal death, Emerging Infectious Diseases, Vol: 13, Pages: 1239-1243, ISSN: 1080-6040

We investigated the zoonotic potential of Waddlia chondrophila, a new Chlamydia-like abortigenic agent in ruminants. Anti-Waddlia antibody reactivity was tested by immunofluorescence and Western blot. Waddlia seroprevalence was higher in women who had had sporadic and recurrent miscarriages than in control women (p<0.001). Waddlia spp. may represent a cause of human fetal loss.

Journal article

Stewart EA, Gostout B, Rabinovici J, Kim HS, Regan L, Tempany CMCet al., 2007, Sustained relief of leiomyoma symptoms by using focused ultrasound surgery, OBSTETRICS AND GYNECOLOGY, Vol: 110, Pages: 279-287, ISSN: 0029-7844

Journal article

Jindal P, Regan L, Fourkala EO, Rai R, Moore G, Goldin RD, Sebire NJet al., 2007, Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review, HUMAN REPRODUCTION, Vol: 22, Pages: 313-316, ISSN: 0268-1161

Journal article

Smart OC, Gedroyc WG, Regan LR, 2007, Pelvic schwannoma: a retroperitoneal tumour mimicking uterine leiomyoma., J Obstet Gynaecol, Vol: 27, Pages: 94-96, ISSN: 0144-3615

Journal article

Malik S, Regan L, 2007, Debate: should progesterone supplements be used in recurrent pregnancy loss?, Recurrent pregnancy loss: causes, controversies and treatment, Editors: Carp, Publisher: Informa Healthcare, Pages: 93-96

Book chapter

Rai R, Regan L, 2006, Recurrent miscarriage, LANCET, Vol: 368, Pages: 601-611, ISSN: 0140-6736

Journal article

Smart OC, Hindley JT, Regan L, Gedroyc WMWet al., 2006, Magnetic resonance guided focused ultrasound surgery of uterine fibroids - The tissue effects of GnRH agonist pre-treatment, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 59, Pages: 163-167, ISSN: 0720-048X

Journal article

Bose P, Kadyrov M, Goldin R, Hahn S, Backos M, Regan L, Huppertz Bet al., 2006, Aberrations of early trophoblast differentiation predispose to pregnancy failure: Lessons from the anti-phospholipid syndrome, PLACENTA, Vol: 27, Pages: 869-875, ISSN: 0143-4004

Journal article

Francis J, Rai R, Sebire NJ, El-Gaddal S, Fernandes MS, Jindal P, Lokugamage A, Regan L, Brosens JJet al., 2006, Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome, MOLECULAR HUMAN REPRODUCTION, Vol: 12, Pages: 435-442

Journal article

Smart OC, Hindley JT, Regan L, Gedroyc WGet al., 2006, Gonadotrophin-releasing hormone and magnetic-resoniance-guided ultrasound surgery for uterine leiomyomata, OBSTETRICS AND GYNECOLOGY, Vol: 108, Pages: 49-54, ISSN: 0029-7844

Journal article

Rai R, Backos M, Francis J, Brosens J, Regan Let al., 2006, Peripheral blood natural killer cells and recurrent miscarriage - a prospective study, 22nd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology, Publisher: OXFORD UNIV PRESS, Pages: I11-I11, ISSN: 0268-1161

Conference paper

Jivraj S, Rai R, Underwood J, Regan Let al., 2006, Genetic thrombophilic mutations among couples with recurrent miscarriage, HUMAN REPRODUCTION, Vol: 21, Pages: 1161-1165, ISSN: 0268-1161

Journal article

Wu O, Robertson L, Twaddle S, Lowe GDO, Clark P, Greaves M, Walker ID, Langhorne P, Brenkel I, Regan L, Greer IAet al., 2006, Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study, HEALTH TECHNOLOGY ASSESSMENT, Vol: 10, Pages: 1-+, ISSN: 1366-5278

Journal article

Hills FA, Abrahams VM, Gonzalez-Timon B, Francis J, Cloke B, Hinkson L, Rai R, Mor G, Regan L, Sullivan M, Lam EW-F, Brosens JJet al., 2006, Heparin prevents programmed cell death in human trophoblast, MOLECULAR HUMAN REPRODUCTION, Vol: 12, Pages: 237-243

Journal article

Leonce J, Brockton N, Robinson S, Venkatesan S, Bannister P, Raman V, Murphy K, Parker K, Pavitt D, Teoh TG, Regan L, Burchell A, Steer P, Johnston DGet al., 2006, Glucose production in the human placenta, PLACENTA, Vol: 27, Pages: S103-S108, ISSN: 0143-4004

Journal article

Regan L, 2006, El embarazo semana a semana, Publisher: /Dorling Kindersley/Norma S A Editorial, ISBN: 9789580489733

Book

Rai R, Brosens J, Sebire N, Francis J, Goldin R, Regan Let al., 2006, Expression of endometrial complement regulatory proteins in antiphospholipid syndrome., 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 355A-355A, ISSN: 1071-5576

Conference paper

Jindal P, Lo W, Backos M, Jivraj S, Raj R, Regan Let al., 2006, Long term health implications of primary antiphospholipid antibody syndrome in women presenting with recurrent miscarriage prospective longitudinal study., 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 270A-270A, ISSN: 1071-5576

Conference paper

Regan L, Hills F, Abrahams V, Gonzalez-Timon B, Francis J, Hinkson L, Rai R, Mor G, Lam E, Brosens Jet al., 2006, Heparin prevents programmed cell death in human trophoblast., 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 353A-353A, ISSN: 1071-5576

Conference paper

Rai R, Backos M, Francis J, Brosens J, Regan Let al., 2006, Peripheral blood NK cell levels are not predictive of future pregnancy outcome amongst women with recurrent miscarriage - A prospective study., 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 354A-354A, ISSN: 1071-5576

Conference paper

Heeps A, Crouch N, Backos M, Brosens J, Higham J, Rai R, Regan Let al., 2006, Successful prevention of second trimester pregnancy loss using high cervical cerclage., 53rd Annual Scientific Meeting of the Society-for-Gynecologic-Investigation, Publisher: ELSEVIER SCIENCE INC, Pages: 333A-333A, ISSN: 1071-5576

Conference paper

Regan L, 2006, Meine Schwangerschaft Woche für Woche, Publisher: Dorling Kindersley, ISBN: 9783831008575

Book

Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GDO, Walker ID, Greaves M, Brenkel I, Regan L, Greer IAet al., 2006, Thrombophilia in pregnancy: a systematic review, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 132, Pages: 171-196, ISSN: 0007-1048

Journal article

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