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@article{Smith:2022:10.1371/journal.pone.0270150,
author = {Smith, ER and Oakley, E and He, S and Zavala, R and Ferguson, K and Miller, L and Grandner, GW and Abejirinde, I-OO and Afshar, Y and Ahmadzia, H and Aldrovandi, G and Akelo, V and Tippett, Barr BA and Bevilacqua, E and Brandt, JS and Broutet, N and Fernández, Buhigas I and Carrillo, J and Clifton, R and Conry, J and Cosmi, E and Delgado-López, C and Divakar, H and Driscoll, AJ and Favre, G and Flaherman, V and Gale, C and Gil, MM and Godwin, C and Gottlieb, S and Hernandez, Bellolio O and Kara, E and Khagayi, S and Kim, CR and Knight, M and Kotloff, K and Lanzone, A and Le, Doare K and Lees, C and Litman, E and Lokken, EM and Laurita, Longo V and Magee, LA and Martinez-Portilla, RJ and McClure, E and Metz, TD and Money, D and Mullins, E and Nachega, JB and Panchaud, A and Playle, R and Poon, LC and Raiten, D and Regan, L and Rukundo, G and Sanin-Blair, J and Temmerman, M and Thorson, A and Thwin, S and Tolosa, JE and Townson, J and Valencia-Prado, M and Visentin, S and von, Dadelszen },
doi = {10.1371/journal.pone.0270150},
journal = {PLoS One},
title = {Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods},
url = {http://dx.doi.org/10.1371/journal.pone.0270150},
volume = {17},
year = {2022}
}

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TY  - JOUR
AB  - We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines. As the pandemic evolves, additional studies identified retrospectively by the steering committee or through living systematic reviews will be invited to participate in this PMA. Investigators can contribute to the PMA by either submitting individual patient data or running standardized code to generate aggregate data estimates. For the primary analysis, we will pool data using two-stage meta-analysis methods. The meta-analyses will be updated as additional data accrue in each contributing study and as additional studies meet study-specific time or data accrual thresholds for sharing. At the time of publication, investigators of 25 studies, including more than 76,000 pregnancies, in 41 countries had agreed to share data for this analysis. Among the included studies, 12 have a contemporaneous comparison group of pregnancies without COVID-19, and four studies include a comparison group of non-pregnant women of reproductive age with COVID-19. Protocols and updates will be maintained publicly. Results will be shared with key stakeholders, including the World Health Organization (WHO) Maternal, Newborn, Child, and Adolescent Health (MNCAH) Research Working Group. Data contributors will share results with local stakeholders. Scientific publications will be published in open-access journals on an ongoing basis.
AU  - Smith,ER
AU  - Oakley,E
AU  - He,S
AU  - Zavala,R
AU  - Ferguson,K
AU  - Miller,L
AU  - Grandner,GW
AU  - Abejirinde,I-OO
AU  - Afshar,Y
AU  - Ahmadzia,H
AU  - Aldrovandi,G
AU  - Akelo,V
AU  - Tippett,Barr BA
AU  - Bevilacqua,E
AU  - Brandt,JS
AU  - Broutet,N
AU  - Fernández,Buhigas I
AU  - Carrillo,J
AU  - Clifton,R
AU  - Conry,J
AU  - Cosmi,E
AU  - Delgado-López,C
AU  - Divakar,H
AU  - Driscoll,AJ
AU  - Favre,G
AU  - Flaherman,V
AU  - Gale,C
AU  - Gil,MM
AU  - Godwin,C
AU  - Gottlieb,S
AU  - Hernandez,Bellolio O
AU  - Kara,E
AU  - Khagayi,S
AU  - Kim,CR
AU  - Knight,M
AU  - Kotloff,K
AU  - Lanzone,A
AU  - Le,Doare K
AU  - Lees,C
AU  - Litman,E
AU  - Lokken,EM
AU  - Laurita,Longo V
AU  - Magee,LA
AU  - Martinez-Portilla,RJ
AU  - McClure,E
AU  - Metz,TD
AU  - Money,D
AU  - Mullins,E
AU  - Nachega,JB
AU  - Panchaud,A
AU  - Playle,R
AU  - Poon,LC
AU  - Raiten,D
AU  - Regan,L
AU  - Rukundo,G
AU  - Sanin-Blair,J
AU  - Temmerman,M
AU  - Thorson,A
AU  - Thwin,S
AU  - Tolosa,JE
AU  - Townson,J
AU  - Valencia-Prado,M
AU  - Visentin,S
AU  - von,Dadelszen P
AU  - Adams,Waldorf K
AU  - Whitehead,C
AU  - Yang,H
AU  - Thorlund,K
AU  - Tielsch,JM
DO  - 10.1371/journal.pone.0270150
PY  - 2022///
SN  - 1932-6203
TI  - Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0270150
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35709239
UR  - http://hdl.handle.net/10044/1/98007
VL  - 17
ER  -

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