Imperial College London
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ProfessorLesleyRegan

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Professor
 
 
 
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Contact

 

+44 (0)20 3312 1798l.regan

 
 
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Assistant

 

Ms Hazel Blackman +44 (0)20 7594 2104

 
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Location

 

MWG022Mint WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Smith:2023:10.1016/j.ajog.2022.08.038,
author = {Smith, ER and Oakley, E and Grandner, GW and Rukundo, G and Farooq, F and Ferguson, K and Baumann, S and Waldorf, KA and Afshar, Y and Ahlberg, M and Ahmadzia, H and Akelo, V and Aldrovandi, G and Bevilacqua, E and Bracero, N and Brandt, JS and Broutet, N and Carrillo, J and Conry, J and Cosmi, E and Crispi, F and Crovetto, F and Gil, MDM and Delgado-López, C and Divakar, H and Driscoll, AJ and Favre, G and Buhigas, IF and Flaherman, V and Gale, C and Godwin, CL and Gottlieb, S and Gratacós, E and He, S and Hernandez, O and Jones, S and Joshi, S and Kalafat, E and Khagayi, S and Knight, M and Kotloff, K and Lanzone, A and Longo, VL and Le, Doare K and Lees, C and Litman, E and Lokken, EM and Madhi, SA and Magee, LA and Martinez-Portilla, RJ and Metz, TD and Miller, ES and Money, D and Moungmaithong, S and Mullins, E and Nachega, JB and Nunes, MC and Onyango, D and Panchaud, A and Poon, LC and Raiten, D and Regan, L and Sahota, D and Sakowicz, A and Sanin-Blair, J and Stephansson, O and},
doi = {10.1016/j.ajog.2022.08.038},
journal = {American Journal of Obstetrics and Gynecology},
pages = {161--177},
title = {Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis},
url = {http://dx.doi.org/10.1016/j.ajog.2022.08.038},
volume = {228},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: This sequential, prospective meta-analysis (sPMA) sought to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to: disease severity, maternal morbidities, neonatal mortality and morbidity, adverse birth outcomes. DATA SOURCES: We prospectively invited study investigators to join the sPMA via professional research networks beginning in March 2020. STUDY ELIGIBILITY CRITERIA: Eligible studies included those recruiting at least 25 consecutive cases of COVID-19 in pregnancy within a defined catchment area. STUDY APPRAISAL AND SYNTHESIS METHODS: We included individual patient data from 21 participating studies. Data quality was assessed, and harmonized variables for risk factors and outcomes were constructed. Duplicate cases were removed. Pooled estimates for the absolute and relative risk of adverse outcomes comparing those with and without each risk factor were generated using a two-stage meta-analysis. RESULTS: We collected data from 33 countries and territories, including 21,977 cases of SARS-CoV-2 infection in pregnancy or postpartum. We found that women with comorbidities (pre-existing diabetes, hypertension, cardiovascular disease) versus those without were at higher risk for COVID-19 severity and pregnancy health outcomes (fetal death, preterm birth, low birthweight). Participants with COVID-19 and HIV were 1.74 times (95% CI: 1.12, 2.71) more likely to be admitted to the ICU. Pregnant women who were underweight before pregnancy were at higher risk of ICU admission (RR 5.53, 95% CI: 2.27, 13.44), ventilation (RR 9.36, 95% CI: 3.87, 22.63), and pregnancy-related death (RR 14.10, 95% CI: 2.83, 70.36). Pre-pregnancy obesity was also a risk factor for severe COVID-19 outcomes including ICU admission (RR 1.81, 95% CI: 1.26,2.60), ventilation (RR 2.05, 95% CI: 1.20,3.51), any critical care (RR 1.89, 95% CI: 1.28,2.77), and pneumonia (RR 1.66, 95% CI: 1.18,2.33). Anemic pregnant women with COVID-19 also had in
AU  - Smith,ER
AU  - Oakley,E
AU  - Grandner,GW
AU  - Rukundo,G
AU  - Farooq,F
AU  - Ferguson,K
AU  - Baumann,S
AU  - Waldorf,KA
AU  - Afshar,Y
AU  - Ahlberg,M
AU  - Ahmadzia,H
AU  - Akelo,V
AU  - Aldrovandi,G
AU  - Bevilacqua,E
AU  - Bracero,N
AU  - Brandt,JS
AU  - Broutet,N
AU  - Carrillo,J
AU  - Conry,J
AU  - Cosmi,E
AU  - Crispi,F
AU  - Crovetto,F
AU  - Gil,MDM
AU  - Delgado-López,C
AU  - Divakar,H
AU  - Driscoll,AJ
AU  - Favre,G
AU  - Buhigas,IF
AU  - Flaherman,V
AU  - Gale,C
AU  - Godwin,CL
AU  - Gottlieb,S
AU  - Gratacós,E
AU  - He,S
AU  - Hernandez,O
AU  - Jones,S
AU  - Joshi,S
AU  - Kalafat,E
AU  - Khagayi,S
AU  - Knight,M
AU  - Kotloff,K
AU  - Lanzone,A
AU  - Longo,VL
AU  - Le,Doare K
AU  - Lees,C
AU  - Litman,E
AU  - Lokken,EM
AU  - Madhi,SA
AU  - Magee,LA
AU  - Martinez-Portilla,RJ
AU  - Metz,TD
AU  - Miller,ES
AU  - Money,D
AU  - Moungmaithong,S
AU  - Mullins,E
AU  - Nachega,JB
AU  - Nunes,MC
AU  - Onyango,D
AU  - Panchaud,A
AU  - Poon,LC
AU  - Raiten,D
AU  - Regan,L
AU  - Sahota,D
AU  - Sakowicz,A
AU  - Sanin-Blair,J
AU  - Stephansson,O
AU  - Temmerman,M
AU  - Thorson,A
AU  - Thwin,SS
AU  - Tippett,Barr BA
AU  - Tolosa,JE
AU  - Tug,N
AU  - Valencia-Prado,M
AU  - Visentin,S
AU  - von,Dadelszen P
AU  - Whitehead,C
AU  - Wood,M
AU  - Yang,H
AU  - Zavala,R
AU  - Tielsch,JM
DO  - 10.1016/j.ajog.2022.08.038
EP  - 177
PY  - 2023///
SN  - 0002-9378
SP  - 161
TI  - Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: A sequential, prospective meta-analysis
T2  - American Journal of Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1016/j.ajog.2022.08.038
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36027953
UR  - http://hdl.handle.net/10044/1/99375
VL  - 228
ER  -
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