Imperial College London
Dr Lesley Rushton

DrLesleyRushton

Faculty of Medicine, School of Public Health

Emeritus Reader of Occupational Epidemiology
 
 
 
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Contact

 

l.rushton

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

191 results found

Fritschi L, Carey R, Peters S, Reid A, Driscoll T, Rushton L, Glass D, Hutchings Set al., 2014, 0357 The lifetime risk approach to estimating the burden of occupational cancer.

OBJECTIVES: The main approaches to estimating the burden of occupational cancer are attributable risk and lifetime risk. In this presentation we will explain why we used the lifetime risk approach. METHOD: The lifetime risk of cancer is an estimation of an individual's risk of being diagnosed with cancer during their life (without considering occupational exposures). The lifetime risk for the general population (LRGP) is estimated by multiplying cohort person-years-at-risk (from life table data) by age-sex specific incidence rates. The excess lifetime risk of cancer in a cohort of workers exposed to the carcinogen of interest (LRexposed) is a product of the LRGP and the excess relative risk of developing cancer associated with that exposure. LRexposed is multiplied by the prevalence of exposure to obtain the number of cancers attributable to the exposure in the general working population. RESULTS: The lifetime risk approach estimates the number of cancers which would occur over a number of years in the future, due to exposures in a specific year. In contrast, the attributable risk approach estimates the number of cancers which would occur in a specific year due to exposures over a number of years in the past. Because we had exposure prevalence information for a specific year based on a national survey, we determined that the lifetime risk approach was more applicable in our case. CONCLUSIONS: The lifetime risk approach is an alternative method for calculating burden of disease when exposure prevalence information is available.

Conference paper

Demers P, Peters C, Davies H, Kim J, Pahwa M, McLeod C, Nicol AM, Labreche F, Lavoue J, Hutchings S, Rushton Let al., 2014, 0402 Incorporating more detailed exposure assessment with quantitative estimates is assessing the burden of occupational cancer.

OBJECTIVES: In recent years, several new burden projects have been initiated with increased methodological sophistication. Previous studies have varied with respect to methods used to identify the prevalence and relevant levels of exposure, but many have relied on CAREX estimates. In this presentation, we will focus on the impact of incorporating more detailed exposure assessments with quantitative estimates as part of the Canadian burden of cancer project. METHOD: The Canadian exposure estimation process relies on data from CAREX Canada, taking into account industry and occupation at a more detailed level than previously. For many common carcinogens, the Canadian Workplace Exposure Database is used to account for changes in exposure levels over time and quantitative exposure-response relationships from the literature are used to assign relative risks relevant to the mean level of each exposure group. Historical employment trends are based upon census data at multiple time-points with province, sex, industry, and occupation detail. RESULTS: Developing estimates for approximately 300 industries, as well as by occupation, and the need for estimating the age and gender characteristics of predicted cases to estimate economic burden, has also increased the complexity of estimating historic labour force dynamics. Annual labour force data 1976-2010 is used to attribute age- and tenure-distribution characteristics by province, sex, and industry. CONCLUSIONS: Although our main objective was to increase the validity of the burden estimation process, the more detailed exposure estimates allow us to calculated cancer burden for much more specific industry sectors and occupations, allowing for detailed risk reduction strategies.

Conference paper

Hutchings S, Ayres J, Cullinan P, Fishwick D, Jarvis D, De Matteis S, Sadhra S, Wheatley M, Rushton Let al., 2014, 0148 Using the UK Biobank study to estimate occupational causes of chronic disease: comparability with the UK national population and adjustment for bias.

OBJECTIVES: The UK Biobank study is a sample of 502,682 people aged 40-70, clustered around 22 assessment centres. As part of a project to investigate the causes of COPD and estimate the UK occupational burden, we have assessed the sample's representativeness with respect to the UK national population, with a view to accounting for potential biases. METHOD: We have compared characteristics of the Biobank population (age, education, employment, smoking etc) to that of the UK population as estimated from national data sources. RESULTS: Deprivation index scores indicate that Biobank respondents in more affluent wards are over-represented (52% of Biobank respondents versus 28% nationally have scores of less than -2). The Biobank respondents are also better-educated (33% to degree level, 17% nationally), with similar qualification levels in men and women, whereas more men than women nationally in this age range had higher level qualifications. Fewer were currently employed than nationally (58% vs. 65%), particularly men over 60, with more retired (45% vs. 33%), and fewer disabled or unemployed. There are more in managerial and professional (54% vs. 46%), and fewer in routine and manual occupations (22%, 33% nationally), and fewer smokers (33% vs. 49%). Fewer in the already under-represented unskilled occupations (47% vs. 70% for other occupations), or with reported respiratory ill-health (50% vs. 59%) have a usable email address. CONCLUSIONS: As Biobank respondents are on average less deprived, better educated and under-represented in unskilled occupations than the national population, estimating national occupational COPD burden, and collecting further data without bias will require data adjustments.

Conference paper

Driscoll T, Hutchings S, Rushton L, 2014, 0256  Holes in the burden estimates - some can be filled, some maybe not0256  Holes in the burden estimates - some can be filled, some maybe not.

OBJECTIVES: To consider the data shortcomings and methodological decisions involved in current burden of disease studies and the potential for these to be overcome and/or standardised. METHOD: Most burden of disease estimates require considerable assumptions or methodological decisions about factors concerning exposure, the appropriate relative risk to match with the exposure, and/or the size of the exposed population. These assumptions usually arise from a lack of data and could be largely overcome by the provision of better data. It is reasonable to expect that for some areas these data will improve with time, but for other areas the required data will probably never be available. Other assumptions or methodological approaches vary depending primarily on theoretical considerations that are arguable and unlikely to ever be definitively solved by better data availability. Modelling may sometimes be of use but may not always be appropriate or practical and is still likely to involve some assumptions. RESULTS: For example, some countries have reasonable estimates of asbestos exposure and some have good data on at least one asbestos-related outcome (mesothelioma incidence/mortality). How can this information be validly used for burden estimates where such data are poor? CONCLUSIONS: It is helpful to consider the extent to which burden estimates vary depending on the assumptions and methodologies involved when assessing the validity of estimates and their usefulness. Consideration of the potential for future improvements in data and better understanding of theoretical aspects should be an important input into the planning of future burden of disease work.

Conference paper

Glass DC, Schnatter AR, Tang G, Irons RD, Rushton Let al., 2014, Risk of myeloproliferative disease and chronic myeloid leukaemia following exposure to low-level benzene in a nested case-control study of petroleum workers, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 71, Pages: 266-274, ISSN: 1351-0711

Journal article

Rushton L, Schnatter AR, Tang G, Glass DCet al., 2014, Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers, BRITISH JOURNAL OF CANCER, Vol: 110, Pages: 783-787, ISSN: 0007-0920

Journal article

Sadhra S, Kurmi O, Rushton L, Fishwick D, Ayres J, Cullinan Pet al., 2013, Systematic review of job exposure matrix used in population COPD studies, EUROPEAN RESPIRATORY JOURNAL, Vol: 42, ISSN: 0903-1936

Journal article

Fishwick D, Kurmi O, Chambers H, Rushton L, Cullinan P, Ayres J, Sadhra Set al., 2013, Job exposure matrix development for SOC 2000 occupational codes, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Boobis A, Flari V, Gosling JP, Hart A, Craig P, Rushton L, Idahosa-Taylor Eet al., 2013, Interpretation of the margin of exposure for genotoxic carcinogens - Elicitation of expert knowledge about the form of the dose response curve at human relevant exposures, FOOD AND CHEMICAL TOXICOLOGY, Vol: 57, Pages: 106-118, ISSN: 0278-6915

Journal article

Murray CJL, Richards MA, Newton JN, Fenton KA, Anderson HR, Atkinson C, Bennett D, Bernab E, Blencowe H, Bourne R, Braithwaite T, Brayne C, Bruce NG, Brugha TS, Burney P, Dherani M, Dolk H, Edmond K, Ezzati M, Flaxman AD, Fleming TD, Freedman G, Gunnell D, Hay RJ, Hutchings SJ, Ohno SL, Lozano R, Lyons RA, Marcenes W, Naghavi M, Newton CR, Pearce N, Pope D, Rushton L, Salomon JA, Shibuya K, Vos T, Wang H, Williams HC, Woolf AD, Lopez AD, Davis Aet al., 2013, UK health performance: findings of the Global Burden of Disease Study 2010, LANCET, Vol: 381, Pages: 997-1020, ISSN: 0140-6736

Journal article

Lozano R, Naghavi M, Foreman K, AlMazroa MA, Memish ZAet al., 2013, Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2095, 2012), LANCET, Vol: 381, Pages: 628-628, ISSN: 0140-6736

Journal article

Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez M-G, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous SA, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT-A, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, De Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Maria Haro J, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J-P, King CH, Knowlton LM, Kobusingye O, Koet al., 2012, Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, LANCET, Vol: 380, Pages: 2197-2223, ISSN: 0140-6736

Journal article

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez M-G, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous SA, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle GR, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT-A, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Maria Haro J, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo J-P, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi Ret al., 2012, Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, LANCET, Vol: 380, Pages: 2163-2196, ISSN: 0140-6736

Journal article

Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen JS, Cheng AT-A, Child JC, Cohen A, Colson KE, Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane MM, Flaxman S, Fowkes FGR, Freedman G, Freeman MK, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD, Hoy D, Hu H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R, Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang Y-H, Khatibzadeh S, Khoo J-P, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Mensah GA, Merriman TR, Micha R, Michaud C, Mishra V, Hanafiah KM, Mokdad AA, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson PK, Miquel Nolla J, Norman R, Olives C, Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CDH, Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M, Phillips MR, Pope D, Pope CA, Powles J, Rao M, Razavi H, Rehfuess EA, Rehm JT, Ritz B, Rivara FP, Roberts T, Robinson C, Rodriguez-Portales JA, Romieu I, Room R, Rosenfeld LC, Roy A, Rushton L, Salomon JA, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh GM, Sleet DA, Smith E, Smith KR, Stapelberg NJC, Steenland K, Stoeckl H, Stovner LJ, Stet al., 2012, A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010, LANCET, Vol: 380, Pages: 2224-2260, ISSN: 0140-6736

Journal article

Rushton L, 2012, Re: The Diesel Exhaust in Miners Study: A Nested Case-Control Study of Lung Cancer and Diesel Exhaust and a Cohort Mortality Study with Emphasis on Lung Cancer Response, JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 104, Pages: 1847-1848, ISSN: 0027-8874

Journal article

Schnatter AR, Glass DC, Tang G, Irons RD, Rushton Let al., 2012, Myelodysplastic Syndrome and Benzene Exposure Among Petroleum Workers: An International Pooled Analysis, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol: 104, Pages: 1724-1737, ISSN: 0027-8874

Journal article

Rushton L, Hutchings S, 2012, Reply: Ionising radiation and occupational cancer in Britain, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: 1662-1662, ISSN: 0007-0920

Journal article

Hutchings S, Cherrie JW, Van Tongeren M, Rushton Let al., 2012, Intervening to Reduce the Future Burden of Occupational Cancer in Britain: What Could Work?, CANCER PREVENTION RESEARCH, Vol: 5, Pages: 1213-1222, ISSN: 1940-6207

Journal article

Young C, Rushton L, 2012, Occupational cancer in Britain Skin cancer, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S71-S75, ISSN: 0007-0920

Journal article

Hutchings SJ, Rushton L, 2012, Occupational cancer in Britain Industry sector results, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S92-S103, ISSN: 0007-0920

Journal article

Brown T, Young C, Rushton L, 2012, Occupational cancer in Britain Remaining cancer sites: brain, bone, soft tissue sarcoma and thyroid, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S85-S91, ISSN: 0007-0920

Journal article

Brown T, Rushton L, 2012, Occupational cancer in Britain Haematopoietic malignancies: leukaemia, multiple myeloma, non-Hodgkins lymphoma, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S41-S48, ISSN: 0007-0920

Journal article

Hutchings SJ, Rushton L, 2012, Occupational cancer in Britain Statistical methodology, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S8-S17, ISSN: 0007-0920

Journal article

Slacks R, Young C, Rushton L, 2012, Occupational cancer in Britain Female cancers: breast, cervix and ovary, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S27-S32, ISSN: 0007-0920

Journal article

Bevan R, Young C, Holmes P, Fortunato L, Slack R, Rushton Let al., 2012, Occupational cancer in Britain Gastrointestinal cancers: liver, oesophagus, pancreas and stomach, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S33-S40, ISSN: 0007-0920

Journal article

Rushton L, Hutchings SJ, Fortunato L, Young C, Evans GS, Brown T, Bevan R, Slack R, Holmes P, Bagga S, Cherrie JW, Van Tongeren Met al., 2012, Occupational cancer burden in Great Britain, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S3-S7, ISSN: 0007-0920

Journal article

Van Tongeren M, Jimenez AS, Hutchings SJ, MacCalman L, Rushton L, Cherrie JWet al., 2012, Occupational cancer in Britain Exposure assessment methodology, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S18-S26, ISSN: 0007-0920

Journal article

Brown T, Darnton A, Fortunato L, Rushton Let al., 2012, Occupational cancer in Britain Respiratory cancer sites: larynx, lung and mesothelioma, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S56-S70, ISSN: 0007-0920

Journal article

Brown T, Slacks R, Rushton L, 2012, Occupational cancer in Britain Urinary tract cancers: bladder and kidney, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S76-S84, ISSN: 0007-0920

Journal article

Slack R, Young C, Rushton L, 2012, Occupational cancer in Britain Nasopharynx and sinonasal cancers, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: S49-S55, ISSN: 0007-0920

Journal article

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