Dr Lynne Sykes is a Clinical Senior Lecturer at the Institute of Reproductive and Developmental Biology, Imperial College London and a Consultant Obstetrician at Imperial College Healthcare NHS Trust with a specialist interest in preterm birth.
Her main research interest is in the role of inflammation/infection in spontaneous preterm labour, and has been working in this area for the last decade. Lynne's doctoral research explored the potential use of anti-inflammatory agents as a therapeutic strategy for the prevention of preterm labour.
She now leads a team who focus on the on the importance of the immune response in women who deliver preterm. One area of her work aims to decipher the role of viruses on bacterial induced preterm labour, with particular consideration to tissue dependent responses in the context of ascending versus haematogenous spread of infection. The other major part of her research is exploring patient specific immune responses to the gut and vaginal microbiota, and how this influences the risk of preterm labour.
Her research aims are to develop predictive tools based on immuno-phenotyping, deepen understanding of how immune-microbial interactions determines the risk of preterm birth, and to develop a strategy for immunomodulation for the prevention of preterm labour.
et al., 2022, Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response, Nature Communications, Vol:13, ISSN:2041-1723
et al., 2021, Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth, Nature Communications, Vol:12, ISSN:2041-1723
et al., 2021, Euglycaemic ketoacidosis in pregnant women with COVID-19: two case reports, BMC Pregnancy and Childbirth, Vol:21, ISSN:1471-2393
et al., 2021, Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome, Npj Biofilms and Microbiomes, Vol:7, ISSN:2055-5008, Pages:1-10
et al., 2020, Rapid quality improvement in a preterm birth clinic care pathway during the COVID-19 pandemic, Bmj Open Quality, Vol:9, ISSN:2399-6641, Pages:1-9
et al., 2020, Maternal plasma miRNAs as potential biomarkers for detecting risk of small-for-gestational-age births, Ebiomedicine, Vol:62, ISSN:2352-3964
et al., 2020, The pregnancy microbiome and preterm birth, Seminars in Immunopathology, Vol:42, ISSN:1863-2297, Pages:487-499
et al., 2020, Differential response of gestational tissues to TLR3 viral priming prior to exposure to bacterial TLR2 and TLR2/6 agonists, Frontiers in Immunology, Vol:11, ISSN:1664-3224, Pages:1-27
et al., 2019, Cervical length and quantitative fetal fibronectin in the prediction of spontaneous preterm birth in asymptomatic women with congenital uterine anomaly, American Journal of Obstetrics and Gynecology, Vol:221, ISSN:0002-9378, Pages:341.e1-341.e9
et al., 2019, First trimester circulating MicroRNA biomarkers predictive of subsequentpreterm delivery and cervical shortening, Scientific Reports, Vol:9, ISSN:2045-2322
et al., 2014, Anti-inflammatory prostaglandins for the prevention of preterm labour., Reproduction
et al., 2012, The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour, Mediators of Inflammation, Vol:2012, Pages:1-12