Imperial College London
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Dr Lavanya J. Thana

Faculty of Medicine, Department of Brain Sciences

Honorary Research Associate
 
 
 
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Contact

 

+44 (0)20 3313 4161l.thana

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Crawford:2017:10.3310/hta21590,
author = {Crawford, MJ and Gold, C and Odell-Miller, H and Thana, L and Faber, S and Assmus, J and Bieleninik, L and Geretsegger, M and Grant, C and Maratos, A and Sandford, S and Claringbold, A and McConachie, H and Maskey, M and Mossler, KA and Ramchandani, P and Hassiotis, A},
doi = {10.3310/hta21590},
journal = {HEALTH TECHNOLOGY ASSESSMENT},
pages = {1--+},
title = {International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study},
url = {http://dx.doi.org/10.3310/hta21590},
volume = {21},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Preliminary studies have indicated that music therapy may benefit children with autismspectrum disorders (ASD).Objectives:To examine the effects of improvisational music therapy (IMT) on social affect andresponsiveness of children with ASD.Design:International, multicentre, three-arm, single-masked randomised controlled trial, including aNational Institute for Health Research (NIHR)-funded centre that recruited in London and the east ofEngland. Randomisation was via a remote service using permuted blocks, stratified by study site.Setting:Schools and private, voluntary and state-funded health-care services.Participants:Children aged between 4 and 7 years with a confirmed diagnosis of ASD and a parent orguardian who provided written informed consent. We excluded children with serious sensory disorder andthose who had received music therapy within the past 12 months.Interventions:All parents and children received enhanced standard care (ESC), which involved three60-minute sessions of advice and support in addition to treatment as usual. In addition, they wererandomised to either one (low-frequency) or three (high-frequency) sessions of IMT per week, or to ESCalone, over 5 months in a ratio of 1 : 1 : 2.Main outcome measures:The primary outcome was measured using the social affect score derived fromthe Autism Diagnostic Observation Schedule (ADOS) at 5 months: higher scores indicated greater impairment.Secondary outcomes included social affect at 12 months and parent-rated social responsiveness at 5 and12 months (higher scores indicated greater impairment).Results:A total of 364 participants were randomised between 2011 and 2015. A total of 182 children wereallocated to IMT (90 to high-frequency sessions and 92 to low-frequency sessions), and 182 were allocatedto ESC alone. A total of 314 (86.3%) of the total sample were followed up at 5 months [165 (90.7%) inthe intervention group and 149 (81.9%) in the control group]. Among those randomised to IMT, 171(94.0
AU  - Crawford,MJ
AU  - Gold,C
AU  - Odell-Miller,H
AU  - Thana,L
AU  - Faber,S
AU  - Assmus,J
AU  - Bieleninik,L
AU  - Geretsegger,M
AU  - Grant,C
AU  - Maratos,A
AU  - Sandford,S
AU  - Claringbold,A
AU  - McConachie,H
AU  - Maskey,M
AU  - Mossler,KA
AU  - Ramchandani,P
AU  - Hassiotis,A
DO  - 10.3310/hta21590
EP  - 1
PY  - 2017///
SN  - 1366-5278
SP  - 1
TI  - International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study
T2  - HEALTH TECHNOLOGY ASSESSMENT
UR  - http://dx.doi.org/10.3310/hta21590
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000413416300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/53619
VL  - 21
ER  -
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