Summary
Dr. Yates completed her PhD in Dr. Charlotte Dean’s laboratory at MRC Harwell in association with the Biochemistry Department, University of Oxford. Her studies uncovered a novel role for the Planar cell polarity (PCP) signalling pathway in normal branching morphogenesis of the developing lung and kidney.
For her postdoctoral studies, Dr. Yates relocated to Melbourne, Australia, joining the Cell Cycle and Cancer Genetics lab headed by Patrick Humbert at the Peter MacCallum Cancer Centre. Maintaining an interest in cell and tissue polarity Dr. Yates made the transition from developmental biology to cancer cell biology. Loss of cell and tissue polarity is recognized as a hallmark of cancer and is known to be one of the first steps leading to tumour formation. Here, Dr. Yates investigated the role of the cell polarity regulator Scribble, and its cooperation with oncogenic KRas in lung tumourigenesis.
Dr. Laura Yates joined the IRD section, National Heart and Lung Institute, Imperial College, as a Junior Research Fellow in November 2013 where she investigated how aberrant polarity impacts adult lung disease, with a particular focus on COPD and lung cancer.
In 2020 Dr. Yates joined Professor Clare Lloyd's group as a Research Manager, where she aids in the management of Prof Lloyd's research programme, provides support to current PhD students and postdocs and develops protocols and new technology to aid research output.
Publications
Journals
Leach DA, Mohr A, Giotis ES, et al., 2021, The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-12
Akram K, Yates L, Mongey R, et al., 2019, Time-lapse imaging of alveologenesis in mouse precision-cut lung slices, Bio-protocol, Vol:9, ISSN:2331-8325
Akram K, Yates L, Mongey R, et al., 2019, Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-16
Zhang Y, Poobalasingam T, Yates LL, et al., 2018, Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma, Disease Models and Mechanisms, Vol:11, ISSN:1754-8403
Oozeer F, Yates LL, Dean C, et al., 2017, A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin, Scientific Reports, Vol:7, ISSN:2045-2322