Imperial College London
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Dr Laura Martin-Sancho

Faculty of Medicine, Department of Infectious Disease

Lecturer in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 9032 ext 49032laura.martin-sancho Website

 
 
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Location

 

315Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Forst:2022:10.1126/sciadv.abm5859,
author = {Forst, CV and Martin-Sancho, L and Tripathi, S and Wang, G and Dos, Anjos Borges LG and Wang, M and Geber, A and Lashua, L and Ding, T and Zhou, X and Carter, CE and Metreveli, G and Rodriguez-Frandsen, A and Urbanowski, MD and White, KM and Stein, DA and Moulton, H and Chanda, SK and Pache, L and Shaw, ML and Ross, TM and Ghedin, E and García-Sastre, A and Zhang, B},
doi = {10.1126/sciadv.abm5859},
journal = {Science Advances},
title = {Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans},
url = {http://dx.doi.org/10.1126/sciadv.abm5859},
volume = {8},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>            Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, primary epithelial cells, and lung tissues collected from IAV-infected humans, ferrets, and mice. The molecular responses in the human host have unique functions such as antigen processing that are not observed in mice or ferrets. Highly conserved gene coexpression modules across the three species are enriched for IAV infection–induced pathways including cell cycle and interferon (IFN) signaling.            <jats:italic>TDRD7</jats:italic>            is predicted as an IFN-inducible host factor that is up-regulated upon IAV infection in the three species.            <jats:italic>TDRD7</jats:italic>            is required for antiviral IFN response, potentially modulating IFN signaling via the JAK/STAT/IRF9 pathway. Identification of the common and species-specific molecular signatures, networks, and regulators of IAV infection provides insights into host-defense mechanisms and will facilitate the development of novel therapeutic interventions against IAV infection.          </jats:p>
AU  - Forst,CV
AU  - Martin-Sancho,L
AU  - Tripathi,S
AU  - Wang,G
AU  - Dos,Anjos Borges LG
AU  - Wang,M
AU  - Geber,A
AU  - Lashua,L
AU  - Ding,T
AU  - Zhou,X
AU  - Carter,CE
AU  - Metreveli,G
AU  - Rodriguez-Frandsen,A
AU  - Urbanowski,MD
AU  - White,KM
AU  - Stein,DA
AU  - Moulton,H
AU  - Chanda,SK
AU  - Pache,L
AU  - Shaw,ML
AU  - Ross,TM
AU  - Ghedin,E
AU  - García-Sastre,A
AU  - Zhang,B
DO  - 10.1126/sciadv.abm5859
PY  - 2022///
TI  - Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.abm5859
VL  - 8
ER  -
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