Imperial College London
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Dr Laura Martin-Sancho

Faculty of Medicine, Department of Infectious Disease

Lecturer in Molecular Virology
 
 
 
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Contact

 

+44 (0)20 7594 9032 ext 49032laura.martin-sancho Website

 
 
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Location

 

315Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rodriguez-Frandsen:2020:10.1128/jvi.01410-19,
author = {Rodriguez-Frandsen, A and Martin-Sancho, L and Gounder, AP and Chang, MW and Liu, W-C and De, Jesus PD and von, Recum-Knepper J and Dutra, MS and Huffmaster, NJ and Chavarria, M and Mena, I and Riva, L and Nguyen, CB and Dobariya, S and Herbert, KM and Benner, C and Albrecht, RA and García-Sastre, A and Chanda, SK},
doi = {10.1128/jvi.01410-19},
journal = {Journal of Virology},
title = {Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells},
url = {http://dx.doi.org/10.1128/jvi.01410-19},
volume = {94},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Many zoonotic avian influenza A viruses have successfully crossed the species barrier and caused mild to life-threatening disease in humans. While human-to-human transmission is limited, there is a risk that these zoonotic viruses may acquire adaptive mutations enabling them to propagate efficiently and cause devastating human pandemics. Therefore, it is important to identify viral determinants that provide these viruses with a replicative advantage in human cells. Here, we tested the growth of influenza A virus in a subset of human cell lines and found that abortive replication of H1N1 viruses in HeLa cells can be circumvented upon the introduction of H5N1 virus HA and NP. Overall, this work leverages the genetic diversity of multiple human cell lines to highlight viral determinants that could contribute to H5N1 virus pathogenesis and tropism.</jats:p>
AU  - Rodriguez-Frandsen,A
AU  - Martin-Sancho,L
AU  - Gounder,AP
AU  - Chang,MW
AU  - Liu,W-C
AU  - De,Jesus PD
AU  - von,Recum-Knepper J
AU  - Dutra,MS
AU  - Huffmaster,NJ
AU  - Chavarria,M
AU  - Mena,I
AU  - Riva,L
AU  - Nguyen,CB
AU  - Dobariya,S
AU  - Herbert,KM
AU  - Benner,C
AU  - Albrecht,RA
AU  - García-Sastre,A
AU  - Chanda,SK
DO  - 10.1128/jvi.01410-19
PY  - 2020///
SN  - 0022-538X
TI  - Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells
T2  - Journal of Virology
UR  - http://dx.doi.org/10.1128/jvi.01410-19
VL  - 94
ER  -
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