Imperial College London
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DrLeonBarron

Faculty of Medicine, School of Public Health

Reader in Analytical & Environmental Sciences
 
 
 
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Contact

 

leon.barron

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Miller:2017:10.1016/j.chemosphere.2017.05.083,
author = {Miller, TH and Bury, NR and Owen, SF and Barron, LP},
doi = {10.1016/j.chemosphere.2017.05.083},
journal = {Chemosphere},
pages = {389--400},
title = {Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry},
url = {http://dx.doi.org/10.1016/j.chemosphere.2017.05.083},
volume = {183},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Methods were developed to assess uptake and elimination kinetics in Gammarus pulex of nine pharmaceuticals (sulfamethazine, carbamazepine, diazepam, temazepam, trimethoprim, warfarin, metoprolol, nifedipine and propranolol) using targeted LC-MS/MS to determine bioconcentration factors (BCFs) using a 96 h toxicokinetic exposure and depuration period. The derived BCFs for these pharmaceuticals did not trigger any regulatory thresholds and ranged from 0-73 L kg−1 (sulfamethazine showed no bioconcentration). Metabolism of chemicals can affect accurate BCF determination through parameterisation of the kinetic models. The added selectivity of LC-MS/MS allowed us to develop confirmatory methods to monitor the biotransformation of propranolol, carbamazepine and diazepam in G. pulex. Varying concentrations of the biotransformed products; 4-hydroxypropranolol sulphate, carbamazepine-10,11-epoxide, nordiazepam, oxazepam and temazepam were measured following exposure of the precursor compounds. For diazepam, the biotransformation product nordiazepam was present at higher concentrations than the parent compound at 94 ng g−1 dw. Overall, the results indicate that pharmaceutical accumulation is low in these freshwater amphipods, which can potentially be explained by the rapid biotransformation and excretion.
AU  - Miller,TH
AU  - Bury,NR
AU  - Owen,SF
AU  - Barron,LP
DO  - 10.1016/j.chemosphere.2017.05.083
EP  - 400
PY  - 2017///
SN  - 0045-6535
SP  - 389
TI  - Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry
T2  - Chemosphere
UR  - http://dx.doi.org/10.1016/j.chemosphere.2017.05.083
UR  - https://www.sciencedirect.com/science/article/pii/S0045653517307877?via%3Dihub
UR  - http://hdl.handle.net/10044/1/87625
VL  - 183
ER  -
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