Imperial College London
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DrLeonBarron

Faculty of Medicine, School of Public Health

Reader in Analytical & Environmental Sciences
 
 
 
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Contact

 

leon.barron

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shimko:2019:10.1002/dta.2591,
author = {Shimko, KM and O'Brien, JW and Barron, L and Kayalar, H and Mueller, JF and Tscharke, BJ and Choi, PM and Jiang, H and Eaglesham, G and Thomas, KV},
doi = {10.1002/dta.2591},
journal = {Drug Testing And Analysis},
pages = {937--949},
title = {A pilot wastewater-based epidemiology assessment of anabolic steroid use in Queensland, Australia},
url = {http://dx.doi.org/10.1002/dta.2591},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Anabolicandrogenic steroids are synthetic compounds prohibited due to their performance enhancing characteristics. The use of these substances is known to cause healthrelated issues, which highlights the importance of being able to evaluate the scale of consumption by the general population. However, most available research on the analysis of anabolic steroids is focussed on animals and athletes in connection with doping. The potential of wastewaterbased epidemiology as an intelligence tool for the assessment of community level use of anabolic steroids is presented herein. A liquid chromatography tandem mass spectrometry method was developed for the analysis of ten anabolicandrogenic steroids and 14 endogenous hormones in influent wastewater. The validated method was applied to sixteen 24hour composite wastewater influent samples that were collected over a period of five years from two wastewater treatment plants in Queensland, Australia. Nine investigated compounds were found to be present at concentrations between 14611 ng L1 which translated into 3104 mg excreted per 1000 individuals per day. It was concluded that the developed analytical method is suitable for the analysis of AAS in wastewater matrix. Additionally, both the inclusion of metabolites and further investigation into deconjugation by enzymatic hydrolysis would aid in understanding and evaluating community anabolic steroid use. For the first time, this study presents the application of wastewaterbased epidemiology on anabolicandrogenic steroids in Australia.
AU  - Shimko,KM
AU  - O'Brien,JW
AU  - Barron,L
AU  - Kayalar,H
AU  - Mueller,JF
AU  - Tscharke,BJ
AU  - Choi,PM
AU  - Jiang,H
AU  - Eaglesham,G
AU  - Thomas,KV
DO  - 10.1002/dta.2591
EP  - 949
PY  - 2019///
SN  - 1942-7603
SP  - 937
TI  - A pilot wastewater-based epidemiology assessment of anabolic steroid use in Queensland, Australia
T2  - Drug Testing And Analysis
UR  - http://dx.doi.org/10.1002/dta.2591
UR  - http://www.scopus.com/inward/record.url?scp=85065251716&partnerID=8YFLogxK
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/dta.2591
UR  - http://hdl.handle.net/10044/1/85155
VL  - 11
ER  -
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