Imperial College London
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DrLeorRoseman

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

leor.roseman13

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Singleton:2021:10.1101/2021.05.14.444193,
author = {Singleton, SP and Luppi, AI and Carhart-Harris, RL and Cruzat, J and Roseman, L and Nutt, DJ and Deco, G and Kringelbach, ML and Stamatakis, EA and Kuceyeski, A},
doi = {10.1101/2021.05.14.444193},
title = {LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory},
url = {http://dx.doi.org/10.1101/2021.05.14.444193},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Psychedelics like lysergic acid diethylamide (LSD) and psilocybin offer a powerful window into the function of the human brain and mind, by temporarily altering subjective experience through their neurochemical effects. A recent model postulates that serotonin 2a (5-HT2a) receptor agonism allows the brain to explore its dynamic landscape more readily, as reflected by more diverse (entropic) brain activity. We postulate that this increase in entropy may arise in part from a flattening of the brain’s control energy landscape, which can be observed using network control theory to quantify the energy required to transition between recurrent brain states measured using functional magnetic resonance imaging (fMRI) in individuals under LSD, psilocybin, and placebo conditions. We show that LSD and psilocybin reduce the amount of control energy required for brain state transitions, and, furthermore, that, across individuals, LSD’s reduction in control energy correlates with more frequent state transitions and increased entropy of brain state dynamics. Through network control analysis that incorporates the spatial distribution of 5-HT2a receptors from publicly available (non-drug) positron emission tomography (PET) maps, we demonstrate the specific role of this receptor in reducing control energy. Our findings provide evidence that 5-HT2a receptor agonist compounds allow for more facile state transitions and more temporally diverse brain activity. More broadly, by combining receptor-informed network control theory with pharmacological modulation, our work highlights the potential of this approach in studying the impacts of targeted neuropharmacological manipulation on brain activity dynamics.</jats:p><jats:sec><jats:title>Significance Statement</jats:title><jats:p>We present a multi-modal framework for quantifying the effects of two psychedelic drugs (LSD and psilocybin) on br
AU  - Singleton,SP
AU  - Luppi,AI
AU  - Carhart-Harris,RL
AU  - Cruzat,J
AU  - Roseman,L
AU  - Nutt,DJ
AU  - Deco,G
AU  - Kringelbach,ML
AU  - Stamatakis,EA
AU  - Kuceyeski,A
DO  - 10.1101/2021.05.14.444193
PY  - 2021///
TI  - LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory
UR  - http://dx.doi.org/10.1101/2021.05.14.444193
ER  -
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