Imperial College London
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DrLeorRoseman

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

leor.roseman13

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wall:2022:10.1101/2022.02.13.480302,
author = {Wall, MB and Lam, C and Ertl, N and Kaelen, M and Roseman, L and Nutt, DJ and Carhart-Harris, RL},
doi = {10.1101/2022.02.13.480302},
title = {Increased low-frequency brain responses to music after psilocybin therapy for depression},
url = {http://dx.doi.org/10.1101/2022.02.13.480302},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Psychedelic-assisted psychotherapy with psilocybin is an emerging therapy with great promise for depression, and modern psychedelic therapy (PT) methods incorporate music as a key element. Music is an effective emotional/hedonic stimulus that could also be useful in assessing changes in emotional responsiveness following psychedelic therapy. Brain responses to music were assessed before and after PT using functional Magnetic Resonance Imaging (fMRI) and ALFF (Amplitude of Low Frequency Fluctuations) analysis methods. Nineteen patients with treatment-resistant depression underwent two treatment sessions involving administration of psilocybin, with MRI data acquired one week prior and the day after completion of the second of two psilocybin dosing sessions. Comparison of music-listening and resting-state scans revealed significantly greater ALFF in bilateral superior temporal cortex for the post-treatment music scan, and in the right ventral occipital lobe for the post-treatment resting-state scan. ROI analyses of these clusters revealed a significant effect of treatment in the superior temporal lobe for the music scan only. Somewhat consistently, voxelwise comparison of treatment effects showed relative increases for the music scan in the bilateral superior temporal lobes and supramarginal gyrus, and relative decreases in the medial frontal lobes for the resting-state scan. ALFF in these music-related clusters was significantly correlated with intensity of subjective effects felt during the dosing sessions. These data suggest a specific effect of PT on the brain’s response to a hedonic stimulus (music), implying an elevated responsiveness to music after psilocybin therapy that was related to subjective drug effects felt during dosing.</jats:p>
AU  - Wall,MB
AU  - Lam,C
AU  - Ertl,N
AU  - Kaelen,M
AU  - Roseman,L
AU  - Nutt,DJ
AU  - Carhart-Harris,RL
DO  - 10.1101/2022.02.13.480302
PY  - 2022///
TI  - Increased low-frequency brain responses to music after psilocybin therapy for depression
UR  - http://dx.doi.org/10.1101/2022.02.13.480302
ER  -
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