Imperial College London
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DrLeorRoseman

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

leor.roseman13

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jobst:2021:10.1101/2021.01.05.425415,
author = {Jobst, BM and Atasoy, S and Ponce-Alvarez, A and Sanjuán, A and Roseman, L and Kaelen, M and Carhat-Harris, R and Kringelbach, ML and Deco, G},
doi = {10.1101/2021.01.05.425415},
title = {Increased sensitivity to strong perturbations in a whole-brain model of LSD},
url = {http://dx.doi.org/10.1101/2021.01.05.425415},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Lysergic acid diethylamide (LSD) is a potent psychedelic drug, which has seen a revival in clinical and pharmacological research within recent years. Human neuroimaging studies have shown fundamental changes in brain-wide functional connectivity and an expansion of dynamical brain states, thus raising the question about a mechanistic explanation of the dynamics underlying these alterations. Here, we applied a novel perturbational approach based on a whole-brain computational model, which opens up the possibility to externally perturb different brain regions in silico and investigate differences in dynamical stability of different brain states, i.e. the dynamical response of a certain brain region to an external perturbation. After adjusting the whole-brain model parameters to reflect the dynamics of functional magnetic resonance imaging (fMRI) BOLD signals recorded under the influence of LSD or placebo, perturbations of different brain areas were simulated by either promoting or disrupting synchronization in the regarding brain region. After perturbation offset, we quantified the recovery characteristics of the brain area to its basal dynamical state with the Perturbational Integration Latency Index (PILI) and used this measure to distinguish between the two brain states. We found significant changes in dynamical complexity with consistently higher PILI values after LSD intake on a global level, which indicates a shift of the brain’s global working point further away from a stable equilibrium as compared to normal conditions. On a local level, we found that the largest differences were measured within the limbic network, the visual network and the default mode network. Additionally, we found a higher variability of PILI values across different brain regions after LSD intake, indicating higher response diversity under LSD after an external perturbation. Our results provide important new insights into th
AU  - Jobst,BM
AU  - Atasoy,S
AU  - Ponce-Alvarez,A
AU  - Sanjuán,A
AU  - Roseman,L
AU  - Kaelen,M
AU  - Carhat-Harris,R
AU  - Kringelbach,ML
AU  - Deco,G
DO  - 10.1101/2021.01.05.425415
PY  - 2021///
TI  - Increased sensitivity to strong perturbations in a whole-brain model of LSD
UR  - http://dx.doi.org/10.1101/2021.01.05.425415
ER  -
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