Imperial College London
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DrLeorRoseman

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

leor.roseman13

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carhart-Harris:2015:10.1016/j.biopsych.2013.12.015,
author = {Carhart-Harris, RL and Murphy, K and Leech, R and Erritzoe, D and Wall, MB and Ferguson, B and Williams, LTJ and Roseman, L and Brugger, S and De, Meer I and Tanner, M and Tyacke, R and Wolff, K and Sethi, A and Bloomfield, MAP and Williams, TM and Bolstridge, M and Stewart, L and Morgan, C and Newbould, RD and Feilding, A and Curran, HV and Nutt, DJ},
doi = {10.1016/j.biopsych.2013.12.015},
journal = {Biological Psychiatry},
pages = {554--562},
title = {The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity},
url = {http://dx.doi.org/10.1016/j.biopsych.2013.12.015},
volume = {78},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals.MethodsIn a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level–dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week.ResultsMarked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects.ConclusionsThe MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug’s characteristic subjective effects arise from its modulation of spontaneous brain activity.
AU  - Carhart-Harris,RL
AU  - Murphy,K
AU  - Leech,R
AU  - Erritzoe,D
AU  - Wall,MB
AU  - Ferguson,B
AU  - Williams,LTJ
AU  - Roseman,L
AU  - Brugger,S
AU  - De,Meer I
AU  - Tanner,M
AU  - Tyacke,R
AU  - Wolff,K
AU  - Sethi,A
AU  - Bloomfield,MAP
AU  - Williams,TM
AU  - Bolstridge,M
AU  - Stewart,L
AU  - Morgan,C
AU  - Newbould,RD
AU  - Feilding,A
AU  - Curran,HV
AU  - Nutt,DJ
DO  - 10.1016/j.biopsych.2013.12.015
EP  - 562
PY  - 2015///
SN  - 1873-2402
SP  - 554
TI  - The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity
T2  - Biological Psychiatry
UR  - http://dx.doi.org/10.1016/j.biopsych.2013.12.015
UR  - http://hdl.handle.net/10044/1/28877
VL  - 78
ER  -
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