Imperial College London

Professor Lesley Hoyles

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor



lesley.hoyles11 Website




Norfolk PlaceSt Mary's Campus





Metagenomics (microbiome and virome)

Transcriptomics (prokaryote and eukaryote)

Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)

Effect of gut-derived microbial metabolites on host health

Coriobacteriia associated with the gut microbiota

Klebsiella pneumoniae, Klebsiella oxytoca and their bacteriophages


Professor Lesley Hoyles is a microbiologist and computational biologist. The early years of her career focussed on the isolation and phenotypic characterization of novel anaerobic Actinobacteria. Her PhD studies at the University of Reading introduced Professor Hoyles to the gut microbiota, and led her to develop an interest in integrating various -omics and traditional approaches to look at microbe–host interactions and co-metabolism. After completing a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) at University College Cork to develop improved methods for the isolation and characterization of gut-associated bacteriophages, Professor Hoyles was awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics and Theoretical Systems Biology at Imperial College London. Subsequently, she worked in the field of translational systems biology at Imperial, using her unique skill set to investigate host–microbiome interactions and co-metabolism while an MRC Intermediate Research Fellow in Data Science (UK Med-Bio). Professor Hoyles currently holds a full-time position at Nottingham Trent University, and holds an honorary position at Imperial College London.

Selected Publications

Journal Articles

Hoyles L, Fernández-Real J-M, Federici M, et al., 2018, Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women., Nature Medicine, Vol:24, ISSN:1078-8956, Pages:1070-1080

Hoyles L, Jiménez-Pranteda MJ, Chilloux J, et al., 2018, Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota, Microbiome, Vol:6, ISSN:2049-2618

Hoyles L, Snelling T, Umlai UK, et al., 2018, Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier, Microbiome, Vol:6, ISSN:2049-2618

Carding SR, Davis N, Hoyles L, 2017, Review article: The human intestinal virome in health and disease, Alimentary Pharmacology and Therapeutics, Vol:46, ISSN:1365-2036, Pages:800-815

Dumas M, Rothwell AR, Hoyles L, et al., 2017, Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity and impaired glucose tolerance, Cell Reports, Vol:20, ISSN:2211-1247, Pages:136-148

Noble A, Durant L, Hoyles L, et al., 2017, Dysregulation of cellular vs humoral immunity to the intestinal microbiota in inflammatory bowel disease, Journal of Crohns & Colitis, Vol:11, ISSN:1873-9946, Pages:S123-S124

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