Metagenomics (microbiome and virome)
Transcriptomics (prokaryote and eukaryote)
Integration of computational and classical biology to better understand diversity and functionality of the gut microbiome (in vitro and in vivo)
Effect of gut-derived microbial metabolites on host health
Coriobacteriia associated with the gut microbiota
Klebsiella pneumoniae and its bacteriophages
Dr Lesley Hoyles is a microbiologist and computational biologist, and an MRC Intermediate Research Fellow in Data Science (UK Med-Bio). The early years of her career focussed on the isolation and phenotypic characterization of novel anaerobic Actinobacteria. Her PhD studies at the University of Reading introduced Dr Hoyles to the gut microbiota, and led her to develop an interest in integrating various -omics and traditional approaches to look at microbe–host interactions and co-metabolism. After completing a Government of Ireland Postdoctoral Fellowship in Science, Engineering and Technology (IRCSET scheme) at University College Cork to develop improved methods for the isolation and characterization of gut-associated bacteriophages, Dr Hoyles was awarded an MRC Advanced Scholarship to undertake an MSc in Bioinformatics with Theoretical Systems Biology at Imperial College London. Subsequently, Dr Hoyles has worked in the field of translational systems biology at Imperial College London, using her unique skill set to investigate host–microbiome interactions and co-metabolism in humans, and animal and in vitro models.
In addition to her research interests, Dr Hoyles teaches on the MRes Biomedical Research stream Microbiome in Health and Disease. She is heavily involved in outreach activities, running Bugs In Your Guts and an after-school science club, and volunteering at the Turing House CoderDojo. Dr Hoyles is a STEM Ambassador and an Academic Editor for PeerJ.
et al., 2018, Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women., Nature Medicine, Vol:24, ISSN:1078-8956, Pages:1070-1080
et al., 2018, Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota, Microbiome, Vol:6, ISSN:2049-2618
et al., 2017, Dysregulation of cellular vs humoral immunity to the intestinal microbiota in inflammatory bowel disease, Journal of Crohns & Colitis, Vol:11, ISSN:1873-9946, Pages:S123-S124
et al., 2018, Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier, Microbiome, Vol:6, ISSN:2049-2618
Carding SR, Davis N, Hoyles L, 2017, Review article: the human intestinal virome in health and disease, Alimentary Pharmacology & Therapeutics, Vol:46, ISSN:0269-2813, Pages:800-815
et al., 2017, Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance, Cell Reports, Vol:20, ISSN:2211-1247, Pages:136-148