Professor Lesley Hoyles

Martin-Pelaez S, Costabile A, Hoyles L, Rastall RA, Gibson GR, La Ragione RM, Woodward MJ, Mateu E, Martin-Orue SMet al., 2010, Evaluation of the inclusion of a mixture of organic acids or lactulose into the feed of pigs experimentally challenged with <i>Salmonella</i> Typhimurium, VETERINARY MICROBIOLOGY, Vol: 142, Pages: 337-345, ISSN: 0378-1135

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• Citations: 33

Abecia L, Hoyles L, Khoo C, Frantz N, McCartney ALet al., 2010, Effects of a novel galactooligosaccharide on the faecal microbiota of healthy and inflammatory bowel disease cats during a randomized, double-blind, cross-over feeding study, Int J Probiotics Prebiotics, Vol: 5, Pages: 61-68

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Hoyles L, Neve H, McCartney AL, van Sinderen Det al., 2010, Investigation of bacteriophage diversity associated with the human gastrointestinal microbiota, SGM Irish Division: Microbial Viruses: Genomics, Evolution and Applications in Ecology, Biotechnology and Medicine

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Hoyles L, McCartney AL, 2009, What do we mean when we refer to <i>Bacteroidetes</i> populations in the human gastrointestinal microbiota?, FEMS MICROBIOLOGY LETTERS, Vol: 299, Pages: 175-183, ISSN: 0378-1097

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• Citations: 32

Hoyles L, 2009, IN VITRO EXAMINATION OF THE EFFECT OF ORLISTAT ON THE ABILITY OF THE FAECAL MICROBIOTA TO UTILIZE DIETARY LIPIDS

Orlistat is an anti-obesity treatment with which several gastrointestinal (GI) side-effects are commonly associated in the initial stages of therapy. There is no physiological explanation as to why two-thirds of those who take the drug experience one or more side-effects. It has been hypothesized that the GI microbiota may protect from or contribute to these GI disturbances. Using in vitro batch culture and human gut model systems, studies were conducted to determine whether increased availability of dietary lipids and/or orlistat affect the composition and/or activity of the faecal microbiota. Results from 24-h batch culture fermentation experiments demonstrated no effect of orlistat in the presence or absence of a dietary lipid (olive oil) on the composition of bacterial communities [as determined by fluorescence in situ hybridization (FISH) and denaturing gradient gel electrophoresis (DGGE) analyses], but did show there was great variability in the lipolytic activities of the microbiotas of individuals, as determined by gas chromatography analysis of long-chain fatty acids in samples. Subsequent studies focused on the effect of orlistat in the presence and absence of lipid in in vitro human gut model systems. Systems were run for 14 days with gut model medium (GMM) only (to steady state, SS), then fed at 12-h intervals with 50 mg orlistat, 2 g olive oil or a mixture of both for 14 days. FISH and DGGE were used to monitor changes in bacterial populations. Bacteria were cultivated from the GMM only (control) systems at SS. All strains isolated were screened for lipolytic activity using tributyrin agar. FISH and DGGE demonstrated that none of the compounds (singly or in combination) added to the systems had any notable effect on microbial population dynamics for any of the donors, although Subdoligranulum populations appeared to be inhibited by orlistat in the presence or absence of lipid. Orlistat had little or no effect on the metabolism of indigenous and added li

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Honda H, Hoyles L, Logan NA, Halket G, La Ragione RM, McCartney ALet al., 2009, Characterization of Bacillus and related species isolated from human faeces, 5th International Yakult Symposium: the Gut and More; Probiotic Influences Beyond the Gut

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Hoyles L, Daggy BP, McKain N, Wallace RJ, Gibson GR, McCartney ALet al., 2009, In vitro investigations into the effect of orlistat, an anti-obesity therapy, on the human fecal microbiota, American Society for Microbiology, 109th General Meeting

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Hoyles L, Honda H, Logan NA, Halket G, La Ragione RM, McCartney ALet al., 2008, Isolation of Bacillus clausii, Bacillus licheniformis and other bacilli from human faecal samples, INRA–Rowett 2008: Gut Microbiome: Functionality, Interaction with the Host and Impact on the Environment

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Hoyles L, Vulevic J, 2008, Diet, immunity and functional foods, GI MICROBIOTA AND REGULATION OF THE IMMUNE SYSTEM, Vol: 635, Pages: 79-92, ISSN: 0065-2598

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• Citations: 26

Hoyles L, Clear JA, Gibson GR, McCartney ALet al., 2007, Detection of Actinobacteria associated with the human faecal microbiota, 14th International Symposium on the Biology of Actinomycetes

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Tuohy KM, Pinart-Gilberga M, Jones M, Hoyles L, McCartney AL, Gibson GRet al., 2007, Survivability of a probiotic <i>Lactobacillus casei</i> in the gastrointestinal tract of healthy human volunteers and its impact on the faecal microflora, JOURNAL OF APPLIED MICROBIOLOGY, Vol: 102, Pages: 1026-1032, ISSN: 1364-5072

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• Citations: 69

Hoyles L, Daggy BP, Gibson GR, McCartney ALet al., 2006, In vitro investigations of the effects of orlistat on the human faecal microbiota, SGM meeting

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Euzéby JP, Hoyles L, Kämpfer P, Oren A, Saddler GS, Trüper HG, Tindall BJet al., 2004, 'List of changes in taxonomic opinion':: making use of the new lists, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 54, Pages: 1429-1430, ISSN: 1466-5026

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• Citations: 6

Collins MD, Hoyles L, Foster G, Falsen Eet al., 2004, <i>Corynebacterium caspium</i> sp nov., from a Caspian seal (<i>Phoca caspica</i>), INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 54, Pages: 925-928, ISSN: 1466-5026

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• Citations: 55

Hoyles L, Collins MD, Foster G, Falsen E, Schumann Pet al., 2004, <i>Jeotgalicoccus pinnipedialis</i> sp nov., from a southern elephant seal (<i>Mirounga leonina</i>), INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 54, Pages: 745-748, ISSN: 1466-5026

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• Citations: 19

Hoyles L, Collins MD, Falsenz E, Nikolaitchouk N, McCartney ALet al., 2004, Transfer of members of the genus <i>Falcivibrio</i> to the genus <i>Mobiluncus</i>, and emended description of the genus <i>Mobiluncus</i>, SYSTEMATIC AND APPLIED MICROBIOLOGY, Vol: 27, Pages: 72-83, ISSN: 0723-2020

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• Citations: 16

Hoyles L, Falsen E, Foster G, Collins MDet al., 2002, <i>Actinomyces coleocanis</i> sp nov., from the vagina of a dog, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 52, Pages: 1201-1203, ISSN: 1466-5026

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• Citations: 13

Hoyles L, Inganäs E, Falsen E, Drancourt M, Weiss N, McCartney AL, Collins MDet al., 2002, <i>Bifidobacterium scardovii</i> sp nov., from human sources, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 52, Pages: 995-999, ISSN: 1466-5026

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• Citations: 52

Collins MD, Hoyles L, Foster G, Falsen E, Weiss Net al., 2002, <i>Arthrobacter nasiphocae</i> sp nov., from the common seal (<i>Phoca vitulina</i>), INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 52, Pages: 569-571, ISSN: 1466-5026

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• Citations: 16

Hoyles L, Falsen E, Foster G, Rogerson F, Collins MDet al., 2002, <i>Arcanobacterium hippocoleae</i> sp nov., from the vagina of a horse, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 52, Pages: 617-619, ISSN: 1466-5026

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• Citations: 20

Hoyles L, Falsen E, Foster G, Rogerson F, Collins MDet al., 2002, Arcanobacterium hippocoleae sp. nov., from the vagina of a horse., Int J Syst Evol Microbiol, Vol: 52, Pages: 617-619, ISSN: 1466-5026

A polyphasic taxonomic study was performed on a previously unidentified gram-positive, facultatively anaerobic, diphtheroid-shaped organism isolated from a vaginal discharge of a horse. Comparative 16S rRNA gene sequencing demonstrated that the strain was a member of the genus Arcanobacterium, but sequence divergence values of >4% with described species of this genus (viz: Arcanobacterium haemolyticum, Arcanobacterium bernardiae, Arcanobacterium phocae, Arcanobacterium pluranimalium and Arcanobacterium pyogenes) demonstrated that the isolate represented a novel species. The unknown bacterium was readily distinguished from other Arcanobacterium species by biochemical tests. Based on phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Arcanobacterium hippocoleae sp. nov. The type strain of A. hippocoleae is CCUG 44697T (= CIP 106850T).

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Collins MD, Hoyles L, Foster G, Falsen E, Weiss Net al., 2002, Arthrobacter nasiphocae sp. nov., from the common seal (Phoca vitulina)., Int J Syst Evol Microbiol, Vol: 52, Pages: 569-571, ISSN: 1466-5026

An unknown gram-positive, catalase-positive, strictly aerobic, rod-shaped bacterium was isolated from the nasal cavities of two common seals. Chemical analysis revealed the presence in the bacterium of a hitherto unknown cell-wall murein [type: L-Lys-L-Ala2-Gly(2-3)-L-Ala (Gly)]. Comparative 16S rRNA gene sequencing showed that the unidentified rod was related to the Arthrobacter group of organisms, although sequence divergence values of >3% from established members of this genus indicated that it represents a novel species. On the basis of phenotypic and phylogenetic considerations, it is proposed that the unknown bacterium from seals (Phoca vitulina) be classified as a novel species, Arthrobacter nasiphocae sp. nov. The type strain of Arthrobacter nasiphocae is CCUG 42953T.

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Hoyles L, Falsen E, Foster G, Rogerson F, Collins MDet al., 2002, Arcanobacterium hippocoleae sp. nov., from the vagina of a horse, International Journal of Systematic and Evolutionary Microbiology, Vol: 52, Pages: 617-619, ISSN: 1466-5026

A polyphasic taxonomic study was performed on a previously unidentified Gram-positive, facultatively anaerobic, diphtheroid-shaped organism isolated from a vaginal discharge of a horse. Comparative 16S rRNA gene sequencing demonstrated that the strain was a member of the genus Arcanobacterium, but sequence divergence values of >4% with described species of this genus (viz: Arcanobacterium haemolyticum, Arcanobacterium bernardiae, Arcanobacterium phocae, Arcanobacterium pluranimalium and Arcanobacterium pyogenes) demonstrated that the isolate represented a novel species. The unknown bacterium was readily distinguished from other Arcanobacterium species by biochemical tests. Based on phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Arcanobacterium hippocoleae sp. nov. The type strain of A. hippocoleae is CCUG 44697T (= CIP 106850T).

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• Citations: 22

Collins MD, Hoyles L, Foster G, Falsen E, Weiss Net al., 2002, Arthrobacter nasiphocae sp. nov., from the common seal (Phoca vitulina), International Journal of Systematic and Evolutionary Microbiology, Vol: 52, Pages: 569-571, ISSN: 1466-5026

An unknown Gram-positive, catalase-positive, strictly aerobic, rod-shaped bacterium was isolated from the nasal cavities of two common seals. Chemical analysis revealed the presence in the bacterium of a hitherto unknown cell-wall murein [type: L-Lys-L-Ala2-Gly2-3-L-Ala (Gly)]. Comparative 16S rRNA gene sequencing showed that the unidentified rod was related to the Arthrobacter group of organisms, although sequence divergence values of > 3% from established members of this genus indicated that it represents a novel species. On the basis of phenotypic and phylogenetic considerations, it is proposed that the unknown bacterium from seals (Phoca vitulina) be classified as a novel species, Arthrobacter nasiphocae sp. nov. The type strain of Arthrobacter nasiphocae is CCUG 42953T.

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• Citations: 18

Fry P, Grainger J, Hurst J, Hoyles L, Noble Set al., 2002, Practical Microbiology for Secondary Schools, Practical Microbiology for Secondary Schools, ISBN: 9780953683826

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Collins MD, Hoyles L, Törnqvist E, von Essen R, Falsen Eet al., 2001, Characterization of some strains from human clinical sources which resemble "<i>Leptotrichia sanguinegens</i>":: Description of <i>Sneathia sanguinegens</i> sp nov., gen. nov., SYSTEMATIC AND APPLIED MICROBIOLOGY, Vol: 24, Pages: 358-361, ISSN: 0723-2020

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• Citations: 40

Collins MD, Hoyles L, Hutson RA, Foster G, Falsen Eet al., 2001, <i>Corynebacterium testudinoris</i> sp nov., from a tortoise, and <i>Corynebacterium felinum</i> sp nov., from a Scottish wild cat, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 51, Pages: 1349-1352, ISSN: 1466-5026

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• Citations: 28

Hoyles L, Foster G, Falsen E, Thomson LF, Collins MDet al., 2001, <i>Facklamia miroungae</i> sp nov., from a juvenile southern elephant seal (<i>Mirounga leonina</i>), INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 51, Pages: 1401-1403, ISSN: 1466-5026

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• Citations: 14

Hoyles L, Falsen E, Holmström G, Persson A, Sjödén B, Collins MDet al., 2001, <i>Actinomyces suimastitidis</i> sp nov., isolated from pig mastitis, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 51, Pages: 1323-1326, ISSN: 1466-5026

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• Citations: 10

Collins MD, Hoyles L, Foster G, Sjöden B, Falsen Eet al., 2001, <i>Corynebacterium capitovis</i> sp nov., from a sheep, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol: 51, Pages: 857-860, ISSN: 1466-5026

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• Citations: 13