Imperial College London
Alternate

Dr Lionel Tan

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2065lionel.tan

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mallet:2021:10.3389/fimmu.2021.698808,
author = {Mallet, F and Diouf, L and Meunier, B and Perret, M and Reynier, F and Leissner, P and Quemeneur, L and Griffiths, AD and Moucadel, V and Pachot, A and Venet, F and Monneret, G and Lepape, A and Rimmelé, T and Tan, LK and Brengel-Pesce, K and Textoris, J},
doi = {10.3389/fimmu.2021.698808},
journal = {Front Immunol},
title = {Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study.},
url = {http://dx.doi.org/10.3389/fimmu.2021.698808},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: We analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major surgery. The aim was to identify common features related to virus and injury-associated pathologies and specific features linking one or several viruses to a particular pathological context. METHODS: Overall and individual viral DNAemia were measured over a month using quantitative PCR assays from the 377 patients in the REALISM cohort. These patients were characterised by clinical outcomes [severity scores, mortality, Intensive Care Unit (ICU)-acquired infection (IAI)] and 48 parameters defining their host response after injury (cell populations, immune functional assays, and biomarkers). Association between viraemic event and clinical outcomes or immune markers was assessed using χ2-test or exact Fisher's test for qualitative variables and Wilcoxon test for continuous variables. RESULTS: The cumulative incidence of viral DNAemia increased from below 4% at ICU admission to 35% for each herpesvirus during the first month. EBV, HSV1, HHV6, and CMV were detected in 18%, 12%, 10%, and 9% of patients, respectively. The incidence of high TTV viraemia (>10,000 copies/ml) increased from 11% to 15% during the same period. Herpesvirus viraemia was associated with severity at admission; CMV and HHV6 viraemia correlated with mortality during the first week and over the month. The presence of individual herpesvirus during the first month was significantly associated (p < 0.001) with the occurrence of IAI, whilst herpesvirus DNAemia coupled with high TTV viraemia during the very first week was associated with IAI. Herpesvirus viraemia was associated with a lasting exacerbated host immune response, with concurrent profound immune suppression and hyper inflammation, and delayed return to immune homeostasis. The percentag
AU  - Mallet,F
AU  - Diouf,L
AU  - Meunier,B
AU  - Perret,M
AU  - Reynier,F
AU  - Leissner,P
AU  - Quemeneur,L
AU  - Griffiths,AD
AU  - Moucadel,V
AU  - Pachot,A
AU  - Venet,F
AU  - Monneret,G
AU  - Lepape,A
AU  - Rimmelé,T
AU  - Tan,LK
AU  - Brengel-Pesce,K
AU  - Textoris,J
DO  - 10.3389/fimmu.2021.698808
PY  - 2021///
TI  - Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study.
T2  - Front Immunol
UR  - http://dx.doi.org/10.3389/fimmu.2021.698808
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34795661
VL  - 12
ER  -
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