Imperial College London
Alternate

Dr Lionel Tan

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2065lionel.tan

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bodinier:2021:10.3389/fimmu.2021.795052,
author = {Bodinier, M and Peronnet, E and Brengel-Pesce, K and Conti, F and Rimmelé, T and Textoris, J and Vedrine, C and Quemeneur, L and Griffiths, AD and Tan, LK and Venet, F and Maucort-Boulch, D and Monneret, G and REALISM, study group},
doi = {10.3389/fimmu.2021.795052},
journal = {Front Immunol},
title = {Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients.},
url = {http://dx.doi.org/10.3389/fimmu.2021.795052},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity of the first week evolution of the monocyte HLA-DR (mHLA-DR) surface protein expression in septic patients, a key molecule for adaptive immunity onset. We found and verified four distinctive trajectories endotypes in a discovery (n = 276) and a verification cohort (n = 102). We highlight that 59% of septic patients exhibit low or decreasing mHLA-DR expression while in others mHLA-DR expression increased. This study depicts the first week behavior of mHLA-DR over time after sepsis onset and shows that initial and third day mHLA-DR expression measurements is sufficient for an early risk stratification of sepsis patients. These patients might benefit from immunomodulatory treatment to improve outcomes. Going further, our study introduces a way of deciphering heterogeneity of immune system after sepsis onset which is a first step to reach a more comprehensive landscape of sepsis.
AU  - Bodinier,M
AU  - Peronnet,E
AU  - Brengel-Pesce,K
AU  - Conti,F
AU  - Rimmelé,T
AU  - Textoris,J
AU  - Vedrine,C
AU  - Quemeneur,L
AU  - Griffiths,AD
AU  - Tan,LK
AU  - Venet,F
AU  - Maucort-Boulch,D
AU  - Monneret,G
AU  - REALISM,study group
DO  - 10.3389/fimmu.2021.795052
PY  - 2021///
TI  - Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients.
T2  - Front Immunol
UR  - http://dx.doi.org/10.3389/fimmu.2021.795052
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34912347
VL  - 12
ER  -
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