Imperial College London
Alternate

Dr Lionel Tan

Faculty of Medicine, Department of Infectious Disease

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2065lionel.tan

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hamilton:2017:10.1038/nrurol.2017.25,
author = {Hamilton, C and Tan, L and Miethke, T and Anand, PK},
doi = {10.1038/nrurol.2017.25},
journal = {Nature Reviews Urology},
pages = {284--295},
title = {Immunity to uropathogens: the emerging roles of inflammasomes},
url = {http://dx.doi.org/10.1038/nrurol.2017.25},
volume = {14},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrence of UTIs becoming significantly frequent due  to  the emergence  of antibiotic-resistant bacterial strains.  Recent  research  has  focussed  on  interactions  between the innate  and  adaptive immune responses to pathogens colonizing the urinary tract. Inflammasomes are part of the innate immune defense and respond rapidly to several infectious diseases. Assembly of the multiprotein inflammasome complex activates Caspase-1,   processes proinflammatory cytokines IL-1β and IL-18,  and  induces pyroptosis. These effector pathways,  in  turn, act  at different  levels  to  either prevent  or  resolve  infection,  or  eliminate the  infectious  agent  itself. Whilst in certain instances inflammasome activation promotes tissue pathology, the precise functions  of  inflammasomes  in  UTIs  remain unexplored.  In  this  review,  we  discuss recent studies on the roles of inflammasomes in UTIs with a particular focus on common infections of the urinary tract. An improved understanding of inflammasomes may provide valuable novel approaches for the design of diagnostics and therapeutics for complicated UTIs, thus enabling us to counteract the challenge of drug resistance.
AU  - Hamilton,C
AU  - Tan,L
AU  - Miethke,T
AU  - Anand,PK
DO  - 10.1038/nrurol.2017.25
EP  - 295
PY  - 2017///
SN  - 1759-4812
SP  - 284
TI  - Immunity to uropathogens: the emerging roles of inflammasomes
T2  - Nature Reviews Urology
UR  - http://dx.doi.org/10.1038/nrurol.2017.25
UR  - http://hdl.handle.net/10044/1/44656
VL  - 14
ER  -
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