Imperial College London
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Dr Lucia M. Li

Faculty of Medicine, Department of Brain Sciences

Clinical Lecturer (Neurology)
 
 
 
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Contact

 

lucia.li

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2023:10.1136/bmjopen-2022-069594,
author = {Li, L and Heselgrave, A and Soreq, E and Nattino, G and Rosnati, M and Garbero, E and Zimmerman, K and Graham, N and Moro, F and Novelli, D and Gradisek, P and Magnoni, S and Glocker, B and Zetterberg, H and Bertolini, G and Sharp, D},
doi = {10.1136/bmjopen-2022-069594},
journal = {BMJ Open},
title = {Investigating the characteristics and correlates of systemic inflammation after traumatic brain injury: the TBI-BraINFLAMM study},
url = {http://dx.doi.org/10.1136/bmjopen-2022-069594},
volume = {13},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: A significant environmental risk factor for neurodegenerative disease is traumatic brain injury (TBI). However, it is not clear how TBI results in ongoing chronic neurodegeneration. Animal studies show that systemic inflammation is signalled to the brain. This can result in sustained and aggressive microglial activation, which in turn is associated with widespread neurodegeneration. We aim to evaluate systemic inflammation as a mediator of ongoing neurodegeneration after TBI.Methods and analysis: TBI-braINFLAMM will combine data already collected from two large prospective TBI studies. The CREACTIVE study, a broad consortium which enrolled >8000 patients with TBI to have CT scans and blood samples in the hyperacute period, has data available from 854 patients. The BIO-AX-TBI study recruited 311 patients to have acute CT scans, longitudinal blood samples and longitudinal MRI brain scans. The BIO-AX-TBI study also has data from 102 healthy and 24 non-TBI trauma controls, comprising blood samples (both control groups) and MRI scans (healthy controls only). All blood samples from BIO-AX-TBI and CREACTIVE have already been tested for neuronal injury markers (GFAP, tau and NfL), and CREACTIVE blood samples have been tested for inflammatory cytokines. We will additionally test inflammatory cytokine levels from the already collected longitudinal blood samples in the BIO-AX-TBI study, as well as matched microdialysate and blood samples taken during the acute period from a subgroup of patients with TBI (n=18).We will use this unique dataset to characterise post-TBI systemic inflammation, and its relationships with injury severity and ongoing neurodegeneration.Ethics and dissemination: Ethical approval for this study has been granted by the London—Camberwell St Giles Research Ethics Committee (17/LO/2066). Results will be submitted for publication in peer-review journals, presented at conferences and inform the design of larger observational and experime
AU  - Li,L
AU  - Heselgrave,A
AU  - Soreq,E
AU  - Nattino,G
AU  - Rosnati,M
AU  - Garbero,E
AU  - Zimmerman,K
AU  - Graham,N
AU  - Moro,F
AU  - Novelli,D
AU  - Gradisek,P
AU  - Magnoni,S
AU  - Glocker,B
AU  - Zetterberg,H
AU  - Bertolini,G
AU  - Sharp,D
DO  - 10.1136/bmjopen-2022-069594
PY  - 2023///
SN  - 2044-6055
TI  - Investigating the characteristics and correlates of systemic inflammation after traumatic brain injury: the TBI-BraINFLAMM study
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2022-069594
UR  - http://hdl.handle.net/10044/1/104481
VL  - 13
ER  -
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